Results 1 to 10 of about 12,035 (216)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their ...
Ming Bian
exaly   +3 more sources

Structure-Based Design, Synthesis, and Biological Evaluation of Oxadiazole-Morpholine Hybrids as Potent PARP-1 Inhibitors Inducing Apoptosis in Breast Cancer Cells. [PDF]

Drug Dev Res
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Albujuq NR, Darwish KM, Fahmy SA, Hussein B, Kayed GG, Said MA, Nafie MS.   +6 more
europepmc   +2 more sources

Design, Synthesis, In Silico ADME, Toxicity Prediction and Molecular Docking Studies of Benzimidazole-Oxadiazole Derivatives for α-Glucosidase and Aldose Reductase Pathways as Potent Anti-Diabetic Agents [PDF]

Molecules
In this study, due to the side effect profiles and low efficacy of currently used inhibitors, novel benzimidazole-oxadiazole derivatives (6a–6e, 7a–7e) were synthesized as dual inhibitors of α-GLY and AR.
Mesut Işık, Abdüllatif Karakaya, Ulviye Acar Çevik, Adem Necip, Hatice Esra Duran, Bilge Çiftçi, Yusuf Özkay, Zafer Asım Kaplancıklı, Şükrü Beydemir   +8 more
doaj   +2 more sources

Sulfonamide-Based 2-Amino-1,3,4-Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation. [PDF]

Drug Dev Res
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Arslan Karahan G, Gökçe B, Muhammed MT, Ayan EK, Özçelik AB.   +4 more
europepmc   +2 more sources

Heterocyclic-Based Fungicides: Emerging Strategies for Viable Plant Disease Control. [PDF]

Chem Biodivers
Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Tahlan S, Kaira M, Singh S, Dey H, Pandey KC.   +4 more
europepmc   +2 more sources

Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives

Journal of Saudi Chemical Society, 2014
In the present investigation, a series of 2(4-pyridyl)-5[(aryl/heteroarylamino)-1-oxoethyl]thio-1,3,4-oxadiazole were synthesized using isonicotinohydrazide and substituted aryl/heteroaryl amines using pyridine as solvent.
Jignesh P Raval
exaly   +3 more sources

Structural Modifications of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery. [PDF]

Arch Pharm (Weinheim)
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Koçak Aslan E, Karagüzel A, Gündüz MG.   +2 more
europepmc   +2 more sources

In-silico ADME prediction and molecular docking study of novel benzimidazole-1,3,4-oxadiazole derivatives as CYP51 inhibitors for antimicrobial activity

Journal of Applied Pharmaceutical Research, 2022
A class of innovative benzimidazole-1,3,4-Oxadiazole derivatives is a significant heterocyclic molecule for therapeutic development. In heterocyclic chemistry, the novel 1,3,4-Oxadiazole nucleus has a wide range of uses, including antibacterial ...
Shivanand Kolageri, S Hemanth, Mahesh Parit   +2 more
doaj   +1 more source

A Review of Modern Methods of Synthesis 1, 3, 4-Oxadiazole as a Bioactive Compounds

Wasit Journal for Pure Sciences, 2023
: Oxadiazole ring is a heterocyclic molecule with an oxygen and two nitrogen atoms spread throughout its five-membered structure. There are four different isomers that have been discovered, Because of their wide applications in a range of sectors ...
hajar adeeb
doaj   +1 more source

π–π Noncovalent Interaction Involving 1,2,4- and 1,3,4-Oxadiazole Systems: The Combined Experimental, Theoretical, and Database Study

Molecules, 2021
A series of N-pyridyl ureas bearing 1,2,4- (1a, 2a, and 3a) and 1,3,4-oxadiazole moiety (1b, 2b, 3b) was prepared and characterized by HRMS, 1H and 13C NMR spectroscopy, as well as X-ray diffraction.
Sergey V. Baykov, Alexander S. Mikherdov, Alexander S. Novikov, Kirill K. Geyl, Marina V. Tarasenko, Maxim A. Gureev, Vadim P. Boyarskiy   +6 more
doaj   +1 more source