Results 21 to 30 of about 25,633 (260)

1,3,4-Oxadiazole-containing hybrids as potential anticancer agents: Recent developments, mechanism of action and structure-activity relationships

Journal of Saudi Chemical Society, 2021
Chemotherapy is an important therapeutic approach for the treatment of cancer. Currently, many anticancer drugs are available in the market that plays an important role in cancer treatment, but concerns such as, drug resistance and side effects create an
Swarnagowri Nayak, Santhosh L. Gaonkar, Ebraheem Abdu Musad, Abdullah Mohammed AL Dawsar   +3 more
semanticscholar   +1 more source

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides. [PDF]

Angew Chem Int Ed Engl
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Yu JK, Ludwig JN, Antoni PW, Tymann D, Hansmann MM.   +4 more
europepmc   +3 more sources

Methyl-Thiol-Bridged Oxadiazole and Triazole Heterocycles as Inhibitors of NF-κB in Chronic Myelogenous Leukemia Cells

Biomedicines, 2023
Nuclear factor kappa beta (NF-κB) is a transcriptional factor that plays a crucial role in regulating cancer cell proliferation. Therefore, the inhibition of NF-κB activity by small molecules may be beneficial in cancer therapy.
Basappa Basappa, Young Yun Jung, Akshay Ravish, Zhang Xi, Ananda Swamynayaka, Mahendra Madegowda, Vijay Pandey, Peter E. Lobie, Gautam Sethi, Kwang Seok Ahn   +9 more
doaj   +1 more source

Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase

Molecules, 2022
Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss of cell viability in mammary carcinoma cells ...
Divakar Vishwanath, Swamy S. Girimanchanaika, Dukanya Dukanya, Shobith Rangappa, Ji-Rui Yang, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +7 more
doaj   +1 more source

Green Chemistry Synthesis of Five-Membered Heterocylic Derivatives (1, 3, 4-oxadizoles) by Using Grinding Technique [PDF]

Kirkuk Journal of Science, 2018
In this research we prepared about 28 derivatives of five-membered heterocyclic compounds (1,3,4-oxadizoles) in two lines , in the first line we used phenylhydrazide and in the second line we used 4-hydroxy phenylhydrazide as starting material for ...
Nihad Taha, Eehab Rasheed
doaj   +1 more source

Ultrasonic-Assisted Synthesis of Benzofuran Appended Oxadiazole Molecules as Tyrosinase Inhibitors: Mechanistic Approach through Enzyme Inhibition, Molecular Docking, Chemoinformatics, ADMET and Drug-Likeness Studies

International Journal of Molecular Sciences, 2022
Furan-oxadiazole structural hybrids belong to the most promising and biologically active classes of oxygen and nitrogen containing five member heterocycles which have expanded therapeutic scope and potential in the fields of pharmacology, medicinal ...
Ali Irfan, A. Zahoor, S. Kamal, Mubashir Hassan, A. Kloczkowski   +4 more
semanticscholar   +1 more source

Dispersions of 1,3,4-Oxadiazole-Linked Conjugated Microporous Polymers with Carbon Nanotubes as a High-Performance Electrode for Supercapacitors

, 2022
In this study, we used classical and simple Sonogashira couplings to construct three 1,3,4-oxadiazole-linked conjugated microporous polymers (OXD-CMPs) through the reaction of 2,5-bis­(4-bromophenyl)-1,3,4-oxadiazole (OXD-Br2) as a common partner with ...
Tharwat Hassan Mansoure, Shiao-Wei Kuo, Santosh U. Sharma, Maha Mohamed Samy (10764052), Ming-Shiuan Tsai (12212974), Mohamed Gamal Mohamed, Jyh-Tsung Lee, Jung-Hui Chen (12212977), Ming-Shiuan Tsai, Mohamed Gamal Mohamed (2886701), Maha Mohamed Samy, Jyh-Tsung Lee (2355637), Santosh U. Sharma (11840450), Shiao-Wei Kuo (1468537), Jung-Hui Chen, Tharwat Hassan Mansoure (8307864)   +15 more
core   +1 more source

Synthesis and Biological Evaluation of 1,2,3-Triazole Tethered Thymol-1,3,4-Oxadiazole Derivatives as Anticancer and Antimicrobial Agents

Pharmaceuticals, 2021
A library of 1,2,3-triazole-incorporated thymol-1,3,4-oxadiazole derivatives (6–18) hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8, 9, 10, and 11 exhibited significant antiproliferative activity.
Abdulraheem S. A. Almalki, Syed Nazreen, A. Malebari, N. Ali, A. Elhenawy, Abdullah A. A. Alghamdi, Abrar Ahmad, S. Y. Alfaifi, Meshari A Alsharif, Mohammad Mahboob Alam   +9 more
semanticscholar   +1 more source

N-Phenyl-N-{4-[5-(4-pyridyl)-1,3,4-oxadiazol-2-yl]phenyl}aniline

Acta Crystallographica Section E, 2008
The title compound, C25H18N4O, is a non-planar bipolar ligand containing triphenylamine and 1,3,4-oxadiazole units. In the molecule, the benzene ring, the 1,3,4-oxadiazole ring, and the pyridine ring are twisted slightly with respect to each other ...
Li-Ping Han, Bin Li, Jie Liu
doaj   +1 more source

Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives

Pharmaceuticals, 2021
In order to develop novel chemotherapeutic agents with potent anticancer activities, a series of new 2,5-diaryl/heteroaryl-1,3,4-oxadiazoles were designed and synthesized.
C. Stecoza, G. Nițulescu, C. Draghici, M. Cǎproiu, O. T. Olaru, M. Bostan, M. Mihăilă   +6 more
semanticscholar   +1 more source