Results 21 to 30 of about 10,824 (225)
Frontiers in Chemistry, 2022 Bacterial resistance to antibiotics is an ever-growing problem in heathcare. We have previously identified a set of osmium(II), ruthenium(II), iridium(III) and rhodium(III) half-sandwich type complexes with bidentate monosaccharide ligands possessing ...
Bence Balázs +11 more
doaj +1 more source
Synthesis of Various 3-Substituted 1,2,4-Oxadiazole-Containing Chiral β3- and α-Amino Acids from Fmoc-Protected Aspartic Acid [PDF]
, 2016 Various 3-substituted chiral 1,2,4-oxadiazole-containing Fmoc-β3- and -α-amino acids were synthesized from Fmoc-(l or d)-Asp(OtBu)-OH and Fmoc-l-Asp-OtBu, respectively, in three steps (i.e., condensation of an aspartyl derivative with differentially ...
Jean Martinez (150107) +3 more
core +5 more sources
Therapeutic potential of oxadiazole or furadiazole containing compounds
BMC Chemistry, 2020 As we know that, Oxadiazole or furadi azole ring containing derivatives are an important class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two carbons, one oxygen atom, two nitrogen atoms, and two double bonds is known as ...
Ankit Siwach, Prabhakar Kumar Verma
doaj +1 more source
Molecules, 2022 Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat type 2 diabetes mellitus (T2DM). They may be combined with other medications as an additional treatment or used alone as a monotherapy.
Badrud Duza Mohammad +8 more
doaj +1 more source
Synthesis, Biological Activity, and Toxicity to Zebrafish Embryo of Benzamides Substituted with 1,2,4-Oxadiazole-Linked Pyrazole [PDF]
, 2023 To explore novel pesticidal lead compounds with potential activity, a series of new benzamide compounds substituted with 1,2,4-oxadiazole-linked pyrazole were designed and synthesized based on the active substructure splice principle.
Sen Yang (88300) +17 more
core +1 more source
1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies [PDF]
, 2021 In the current work, some 1,3,4-oxadiazole-naphthalene hybrids were designed and synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for their antiproliferative activity against two human cancer cell lines namely, HepG-2 ...
Ibrahim H. Eissa (10145861) +8 more
core +1 more source
Biomedicines, 2023 Nuclear factor kappa beta (NF-κB) is a transcriptional factor that plays a crucial role in regulating cancer cell proliferation. Therefore, the inhibition of NF-κB activity by small molecules may be beneficial in cancer therapy.
Basappa Basappa +9 more
doaj +1 more source
Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase
Molecules, 2022 Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss of cell viability in mammary carcinoma cells ...
Divakar Vishwanath +7 more
doaj +1 more source
2-Phenyl-5-(p-tolyl)-1,3,4-oxadiazole [PDF]
, 2011 Funding: University of St. Andrews and the Engineering and Physical Science Research Council (EPSRC, UK).The title compound, C15H12N2O, adopts the expected near-planar geometry, the phenyl and tolyl rings being inclined relative to the oxadiazole ring by
Woollins, J. Derek +7 more
core +1 more source
Total Synthesis of Anhydrolycorinone Utilizing Sequential Intramolecular Diels−Alder Reactions of a 1,3,4-Oxadiazole [PDF]
, 2016 A convergent total synthesis of anhydrolycorinone is detailed, enlisting sequential intramolecular Diels−Alder reactions of a suitably substituted 2-amino-1,3,4-oxadiazole defining a novel oxadiazole → furan → benzene Diels−Alder ...
Dale L. Boger (1306542) +1 more
core +1 more source