Results 11 to 20 of about 10,824 (225)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their ...
Wei-Dong Jia, Ming Bian
exaly   +3 more sources

BIOLOGICALLY ACTIVE OXADIAZOLE [PDF]

Journal of Drug Delivery and Therapeutics, 2015
As we know that, Oxadiazole is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five-membered ring and is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogen (-N=) [1,2]. There are three known isomers that is 1,2,4-oxadiazole, 1,2,3-oxadiazole and 1,2,5-oxadiazole (Figure 1.0 ...
Chhama Shukla, Sanchit Srivastav
openaire   +4 more sources

From Bench to Bioactivity: An Integrated Medicinal Development Based on Kinetic and Simulation Assessment of Pyrazolone-Oxadiazole Coupled Benzamide as Promising Inhibitors of Diabetes Mellitus [PDF]

Pharmaceuticals
Background: In this research work, novel pyrazolone-derived oxadiazole-based benzamide derivatives (1–10) were synthesized through unique and facile synthetic routes.
Manal M. Khowdiary, Shifa Felemban
doaj   +2 more sources

Electrocyclic Ring‐Opening of 1,2,4‐Oxadiazole[4,5‐a]piridinium Chloride: a New Route to 1,2,4‐Oxadiazole Dienamino Compounds [PDF]

ChemistryOpen, 2019
1,2,4‐Oxadiazole[4,5‐a]piridinium chloride adds nucleophiles to undergo electrocyclic ring opening affording 1,2,4‐oxadiazole dienamino derivatives. These pyridinium salts represent a special class of Zincke salts that are prone to rearrange when treated
Dr. Stefano Carella, Dr. Misal Giuseppe Memeo, Prof. Paolo Quadrelli   +2 more
doaj   +2 more sources

In-silico ADME prediction and molecular docking study of novel benzimidazole-1,3,4-oxadiazole derivatives as CYP51 inhibitors for antimicrobial activity

Journal of Applied Pharmaceutical Research, 2022
A class of innovative benzimidazole-1,3,4-Oxadiazole derivatives is a significant heterocyclic molecule for therapeutic development. In heterocyclic chemistry, the novel 1,3,4-Oxadiazole nucleus has a wide range of uses, including antibacterial ...
Shivanand Kolageri, S Hemanth, Mahesh Parit   +2 more
doaj   +1 more source

The oxadiazole antibacterials [PDF]

Current Opinion in Microbiology, 2016
The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).
Jeshina, Janardhanan, Mayland, Chang, Shahriar, Mobashery   +2 more
openaire   +2 more sources

Dispersions of 1,3,4-Oxadiazole-Linked Conjugated Microporous Polymers with Carbon Nanotubes as a High-Performance Electrode for Supercapacitors [PDF]

, 2022
In this study, we used classical and simple Sonogashira couplings to construct three 1,3,4-oxadiazole-linked conjugated microporous polymers (OXD-CMPs) through the reaction of 2,5-bis­(4-bromophenyl)-1,3,4-oxadiazole (OXD-Br2) as a common partner with ...
Tharwat Hassan Mansoure, Shiao-Wei Kuo, Santosh U. Sharma, Maha Mohamed Samy (10764052), Ming-Shiuan Tsai (12212974), Mohamed Gamal Mohamed, Jyh-Tsung Lee, Jung-Hui Chen (12212977), Ming-Shiuan Tsai, Mohamed Gamal Mohamed (2886701), Maha Mohamed Samy, Jyh-Tsung Lee (2355637), Santosh U. Sharma (11840450), Shiao-Wei Kuo (1468537), Jung-Hui Chen, Tharwat Hassan Mansoure (8307864)   +15 more
core   +1 more source

A Review of Modern Methods of Synthesis 1, 3, 4-Oxadiazole as a Bioactive Compounds

Wasit Journal for Pure Sciences, 2023
: Oxadiazole ring is a heterocyclic molecule with an oxygen and two nitrogen atoms spread throughout its five-membered structure. There are four different isomers that have been discovered, Because of their wide applications in a range of sectors ...
hajar adeeb
doaj   +1 more source

Transition metal complexes with a new tridentate ligand, 5-[6-(5-mercapto- 1,3,4-oxadiazol-2-yl)pyridin-2-yl]-1,3,4-oxadiazole-2-thiol [PDF]

Journal of the Serbian Chemical Society, 2007
A new ligand 5-[6-(5-mercapto-1,3,4-oxadiazol-2-yl)pyridin-2-yl]-1,3,4-oxadiazole- 2-thiol (L) and its Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesized.
Gudasi Kalagouda, Patil Manjula, Vadavi Ramesh, Shenoy Rashmi, Patil Siddappa   +4 more
doaj   +3 more sources

Synthesis and characterization of 5-aryl-1,3,4-oxadiazole-2(3h)thione derivatives

Journal of Applied Pharmaceutical Research, 2020
1,3,4-oxadiazoles represent a class of heterocyclic five membered compounds it contain two nitrogen and one oxygen of great importance in Pharmaceutical chemistry. This nucleus show four isomeric forms 1,2,4-oxadiazole,1,3,4-oxadiazole, 1,2,5-oxadiazole,
Shailesh Pathak, Sharad Sharma, Vinay Pathak, Mahesh Prasad   +3 more
doaj   +1 more source