Results 11 to 20 of about 12,798 (217)

BIOLOGICALLY ACTIVE OXADIAZOLE [PDF]

Journal of Drug Delivery and Therapeutics, 2015
As we know that, Oxadiazole is a heterocyclic compound containing an oxygen atom and two nitrogen atoms in a five-membered ring and is derived from furan by substitution of two methylene groups (=CH) with two pyridine type nitrogen (-N=) [1,2]. There are three known isomers that is 1,2,4-oxadiazole, 1,2,3-oxadiazole and 1,2,5-oxadiazole (Figure 1.0 ...
Chhama Shukla, Sanchit Srivastav
openaire   +3 more sources

3-(4-Amino-1,2,5-oxadiazol-3-yl)-4-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole

Molbank, 2014
The title compound 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole (ANFF-1) was synthesized by: (1) by reaction of 3,4-bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole (BNFF-1) with gaseous ammonia in toluene and (2)
Philip Pagoria, Maoxi Zhang, Ana Racoveanu, Alan DeHope, Roman Tsyshevsky, Maija M. Kuklja   +5 more
doaj   +2 more sources

Targeting Multiresistant Gram-Positive Bacteria by Ruthenium, Osmium, Iridium and Rhodium Half-Sandwich Type Complexes With Bidentate Monosaccharide Ligands

Frontiers in Chemistry, 2022
Bacterial resistance to antibiotics is an ever-growing problem in heathcare. We have previously identified a set of osmium(II), ruthenium(II), iridium(III) and rhodium(III) half-sandwich type complexes with bidentate monosaccharide ligands possessing ...
Bence Balázs, Zoltán Tóth, István Kacsir, István Kacsir, Adrienn Sipos, Péter Buglyó, László Somsák, Éva Bokor, Gábor Kardos, Péter Bai, Péter Bai, Péter Bai   +11 more
doaj   +1 more source

Development of Benzothiophene–Bearing Bis–oxadiazole Derivatives for Potential Anticancer Targets: Evaluation of DFT, ADME–Tox, and In Silico Docking [PDF]

Chem Biodivers
Innovative synthesis of a novel benzothiophene–based bis–oxadiazole derivatives. The structural characterization was performed using experimental and theoretical methods. Significant anticancer activity against selected cancer cell lines. Three derivatives showed good activity 7b, 7g and 7i with IC50 values 7.5 ± 1.04 and 9.5 ± 1.01 µg/mL.
Madala N, Sharma V, Vinnakota S.
europepmc   +2 more sources

Heterocyclic Compounds as Dipeptidyl Peptidase-IV Inhibitors with Special Emphasis on Oxadiazoles as Potent Anti-Diabetic Agents

Molecules, 2022
Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat type 2 diabetes mellitus (T2DM). They may be combined with other medications as an additional treatment or used alone as a monotherapy.
Badrud Duza Mohammad, Mirza Shahed Baig, Neeraj Bhandari, Falak A. Siddiqui, Sharuk L. Khan, Zubair Ahmad, Farhat S. Khan, Priti Tagde, Philippe Jeandet   +8 more
doaj   +1 more source

Dispersions of 1,3,4-Oxadiazole-Linked Conjugated Microporous Polymers with Carbon Nanotubes as a High-Performance Electrode for Supercapacitors

, 2022
In this study, we used classical and simple Sonogashira couplings to construct three 1,3,4-oxadiazole-linked conjugated microporous polymers (OXD-CMPs) through the reaction of 2,5-bis­(4-bromophenyl)-1,3,4-oxadiazole (OXD-Br2) as a common partner with ...
Tharwat Hassan Mansoure, Shiao-Wei Kuo, Santosh U. Sharma, Maha Mohamed Samy (10764052), Ming-Shiuan Tsai (12212974), Mohamed Gamal Mohamed, Jyh-Tsung Lee, Jung-Hui Chen (12212977), Ming-Shiuan Tsai, Mohamed Gamal Mohamed (2886701), Maha Mohamed Samy, Jyh-Tsung Lee (2355637), Santosh U. Sharma (11840450), Shiao-Wei Kuo (1468537), Jung-Hui Chen, Tharwat Hassan Mansoure (8307864)   +15 more
core   +1 more source

2-Phenyl-5-(p-tolyl)-1,3,4-oxadiazole [PDF]

, 2011
Funding: University of St. Andrews and the Engineering and Physical Science Research Council (EPSRC, UK).The title compound, C15H12N2O, adopts the expected near-planar geometry, the phenyl and tolyl rings being inclined relative to the oxadiazole ring by
Woollins, J. Derek, Cordes, David B., David B. Cordes, J. Derek Woollins, Hua, Guoxiong, Alexandra M. Z. Slawin, Slawin, Alexandra M. Z., Guoxiong Hua, Woollins, J. Derek; id_orcid, Slawin, Alexandra M. Z.; id_orcid, Cordes, David B.; id_orcid   +10 more
core   +1 more source

Methyl-Thiol-Bridged Oxadiazole and Triazole Heterocycles as Inhibitors of NF-κB in Chronic Myelogenous Leukemia Cells

Biomedicines, 2023
Nuclear factor kappa beta (NF-κB) is a transcriptional factor that plays a crucial role in regulating cancer cell proliferation. Therefore, the inhibition of NF-κB activity by small molecules may be beneficial in cancer therapy.
Basappa Basappa, Young Yun Jung, Akshay Ravish, Zhang Xi, Ananda Swamynayaka, Mahendra Madegowda, Vijay Pandey, Peter E. Lobie, Gautam Sethi, Kwang Seok Ahn   +9 more
doaj   +1 more source

Imidazo[1,2‐b]Pyrazole‐1,2,4‐oxadiazole Linked 1,2,3‐Triazoles: Synthesis, Antibacterial, Biofilm, and In Silico Studies [PDF]

Chem Biodivers
A collection of innovative imidazo[1,2‐b]pyrazole–1,2,4‐oxadiazole–1,2,3‐triazole hybrids was conceived via the molecular hybridization of bioactive pharmacophores and produced via a CuAAC methodology. The synthesized compounds exhibited strong antibacterial and antibiofilm properties against gram‐positive bacteria.
Murahari S, Siddoju K.
europepmc   +2 more sources

Synthesis of Various 3-Substituted 1,2,4-Oxadiazole-Containing Chiral β³- and α-Amino Acids from Fmoc-Protected Aspartic Acid

, 2016
Various 3-substituted chiral 1,2,4-oxadiazole-containing Fmoc-β3- and -α-amino acids were synthesized from Fmoc-(l or d)-Asp(OtBu)-OH and Fmoc-l-Asp-OtBu, respectively, in three steps (i.e., condensation of an aspartyl derivative with differentially ...
Jean Martinez (150107), Pierre Fulcrand (2498626), Jean-François Hernandez (2701363), Abdallah Hamzé, (2701360)   +3 more
core   +3 more sources