Results 31 to 40 of about 25,633 (260)

In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics.
P. Deb, N. Al-Shar’i, Katharigatta N. Venugopala, M. Pillay, Pobitra Borah   +4 more
semanticscholar   +1 more source

Synthesis of Various 3-Substituted 1,2,4-Oxadiazole-Containing Chiral β³- and α-Amino Acids from Fmoc-Protected Aspartic Acid

, 2016
Various 3-substituted chiral 1,2,4-oxadiazole-containing Fmoc-β3- and -α-amino acids were synthesized from Fmoc-(l or d)-Asp(OtBu)-OH and Fmoc-l-Asp-OtBu, respectively, in three steps (i.e., condensation of an aspartyl derivative with differentially ...
Jean Martinez (150107), Pierre Fulcrand (2498626), Jean-François Hernandez (2701363), Abdallah Hamzé, (2701360)   +3 more
core   +3 more sources

(1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies

Molecules, 2023
Two new azaheterocycle-based bolas, such as (1-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-bisfunctionalized PEGs, were prepared via Cu-catalyzed click reaction between 2-(4-azidophenyl)-5-(aryl)-oxadiazole-1,3,4 and ...
Mohammed S. Mohammed, Igor S. Kovalev, Natalya V. Slovesnova, Leila K. Sadieva, Vadim A. Platonov, Grigory A. Kim, Rammohan Aluru, Alexander S. Novikov, Olga S. Taniya, Valery N. Charushin   +9 more
doaj   +1 more source

Bioactive Oxadiazoles 2.0

International Journal of Molecular Sciences, 2022
Oxadiazoles are electron-poor, five-membered aromatic heterocycles that contain one oxygen and two nitrogen atoms [...]
openaire   +2 more sources

Synthesis, Biological Activity, and Toxicity to Zebrafish Embryo of Benzamides Substituted with 1,2,4-Oxadiazole-Linked Pyrazole

, 2023
To explore novel pesticidal lead compounds with potential activity, a series of new benzamide compounds substituted with 1,2,4-oxadiazole-linked pyrazole were designed and synthesized based on the active substructure splice principle.
Sen Yang (88300), Chengxia Tan (17095702), Yingying Wang (124944), Zhiran Ju, Zhiyun Li (1361565), Zhiyun Li, Zhiran Ju (11431017), Junhui Wu (6999821), Chengxia Tan, Yang Chen (9737), Mimi Li, Yingying Wang, Mimi Li (497805), Changyuan Wu, Junhui Wu, Yang Chen, Sen Yang, Changyuan Wu (17095699)   +17 more
core   +1 more source

2-(5-Methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-5-phenyl-1,3,4-oxadiazole

IUCrData, 2018
The asymmetric unit of the title compound, C17H13N5O, comprises four independent molecules (A–D). The respective interplanar angles between the phenyl/oxadiazole/methyltriazole/phenyl rings for the four independent molecules are A 8.8 (2), 13.0 (2), 22.5 
Gamal A. El-Hiti, Bakr F. Abdel-Wahab, Mohamed S. Mostafa, Rizk E. Khidre, Amany S. Hegazy, Benson M. Kariuki   +5 more
doaj   +1 more source

1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies

, 2021
In the current work, some 1,3,4-oxadiazole-naphthalene hybrids were designed and synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for their antiproliferative activity against two human cancer cell lines namely, HepG-2 ...
Ibrahim H. Eissa (10145861), Eslam B. Elkaeed (9952518), Marwa A. Saleh (11856664), Emad Gamil Khidr (11856673), Hesham A. El-Mahdy (11856676), Mohamed Hagras (3987836), Abdelrahman A. Abuelkhir (11856670), Ahmed A. El-Husseiny (10038811), Rogy R. Ezz Eldin (11856667)   +8 more
core   +1 more source

Synthesis of N, N΄3, 4-Dialkylamino-1, 2, 5-Oxadiazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2003
N, N΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of N, N΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚C. Under similar conditions N, N΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and N, N΄-3,
Ali Kakanejadifardi, Farshad Delfani, Bijan Ranjbar   +2 more
doaj  

3-[5-(Pyridin-4-yl)-1,3,4-oxadiazol-2-yl]-4H-chromen-4-one

IUCrData, 2016
In the title molecule, C16H9N3O3, the plane of oxadiazole ring is almost coplanar with attached pyridine ring and chromenyl ring system, forming dihedral angles of 2.37 (3) and 6.71 (2)°, respectively.
Dongsoo Koh
doaj   +1 more source

2-Phenyl-5-(p-tolyl)-1,3,4-oxadiazole

, 2011
Funding: University of St. Andrews and the Engineering and Physical Science Research Council (EPSRC, UK).The title compound, C15H12N2O, adopts the expected near-planar geometry, the phenyl and tolyl rings being inclined relative to the oxadiazole ring by
Woollins, J. Derek, Cordes, David B., David B. Cordes, J. Derek Woollins, Hua, Guoxiong, Alexandra M. Z. Slawin, Slawin, Alexandra M. Z., Guoxiong Hua   +7 more
core   +1 more source