Results 51 to 60 of about 10,824 (225)

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, EarlyView.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Síntese e caracterização de novos materiais funcionais contendo 1,2,4-oxadiazol, 1,3,4-oxadiazol e 1,2,3-triazol [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2014Neste trabalho de tese de doutorado são apresentadas as sínteses ecaracterizações de três novas ...
Girotto, Edivandro
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Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source

Síntese de cristais líquidos isônicos e/ou discóticos contendo os heterociclos 1,2,4- E 1,3,4- oxadiazol [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013.A presente dissertacao traz o estudo realizado com moleculas derivadas dos heterociclos 1,
Silva, Danilo Henrique da
core  

Synthetic marvels in tuberculosis research: An in-depth review of 1,3,4-oxadiazole derivatives as antitubercular agents

European Journal of Medicinal Chemistry Reports
Given the growth in drug-resistant and inactive cases of tuberculosis, it is imperative to develop novel, potent chemicals to treat this deadly illness.
Isha Kapila, Ankita Bharwal, Poonam Sharma, Neeraj Choudhary, Vikrant Abbot   +4 more
doaj   +1 more source

SYNTHESIS,ANTIBACTERIAL ACTIVITY OF 2-AMINO 5-PHENYL -1,3,4- OXADIAZOLE DERIVATIVES

مجلة بغداد للعلوم, 2008
In the present investigation, five derivatives were synthesized as potential  antimicrobial   agents , The compounds  are : 2-amino 5-phenyl - 1,3,4-  oxadiazole  dithi-ocarbomate, 2-amino 5-( 4-amino- N,N-dimethyl phenyl)-  1,3,4- oxadiazole,    2 ...
Hussain jassem Mohammed
doaj   +1 more source

Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery

Inorganics, 2022
Metal mediated coupling of isocyanides with substituted N-(pyridine-2-yl) ureas was first used to incorporate privileged biological motifs into platinum metal complexes.
Kirill K. Geyl, Svetlana O. Baykova, Pavel A. Andoskin, Vladimir V. Sharoyko, Anastasiya A. Eliseeva, Sergey V. Baykov, Konstantin N. Semenov, Vadim P. Boyarskiy   +7 more
doaj   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB2 ligands by regioisomeric 1,3,4-oxadiazole ring [PDF]

, 2017
It has been reported that bioisosteric replacement of an 1,2,4-oxadiazole ring by an 1,3,4-oxadiazole ring leads to higher polarity, reduced metabolic degradation by human liver microsomes and reduced interaction with hERG channels.
Schepmann, D., Lueg, C., Corinna Lueg, Vries, H. de, Heitman, L.H., Frehland, B., Henk de Vries, Heimann, D., Wunsch, B., Laura H. Heitman, Bastian Frehland, Dominik Heimann, Bernhard Wünsch, Dirk Schepmann   +13 more
core   +2 more sources

Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties [PDF]

, 2020
Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities.
Smith, Terry K., Bhagwat, Deepak P., Abdul Razak, Nurhayatun S., Sankaranarayanan, Murugesan, Wahab, Roswanira Abdul, Abdul Wahab, Roswanira, Jamalis, Joazaizulfazli, Chander, Subhash   +7 more
core   +1 more source