Results 61 to 70 of about 12,035 (216)

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB2 ligands by regioisomeric 1,3,4-oxadiazole ring [PDF]

, 2017
It has been reported that bioisosteric replacement of an 1,2,4-oxadiazole ring by an 1,3,4-oxadiazole ring leads to higher polarity, reduced metabolic degradation by human liver microsomes and reduced interaction with hERG channels.
Schepmann, D., Lueg, C., Corinna Lueg, Vries, H. de, Heitman, L.H., Frehland, B., Henk de Vries, Heimann, D., Wunsch, B., Laura H. Heitman, Bastian Frehland, Dominik Heimann, Bernhard Wünsch, Dirk Schepmann   +13 more
core   +1 more source

N-[2-(1H-Indol-3-yl)-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)ethyl]-4-methylbenzenesulfonamide

Molbank, 2018
N-[1-Hydrazinyl-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methylbenzenesulfonamide (1) on cyclization with carbon disulfide in ethanolic potassium hydroxide affords N-[2-(1H-indol-3-yl)-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)ethyl]-4 ...
Nikil Purushotham, Boja Poojary
doaj   +1 more source

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source

Oxadiazolone‐Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II‐Induced Vascular Contraction

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
A novel series of candidate AT1 receptor antagonists based on oxadiazolone‐triazole scaffolds was designed and synthesized. Most compounds reduced angiotensin II‐induced vascular contraction in an initial biological screening, with compound 7f emerging as the most active derivative.
Larissa F. L. Ferreira, Daiana G. de A. Vasconcelos, Ruth C. A. Santos, Jivaldo G. Ferreira, Alice V. Araújo, Janaína V. dos Anjos   +5 more
wiley   +1 more source

Revisiting the Formation Mechanism of 1,3,4-Oxadiazole-2(3H)‑ones from Hydrazonyl Chloride and Carbon Dioxide

, 2018
The reaction mechanism for the synthesis of 1,3,4-oxadiazole-2­(3H)-ones from hydrazonyl chloride and CO2 in the presence of CsF/18-crown-6 and toluene, is revisited via density functional theory computations.
Jorge Barroso (3594497), Fernando Murillo (5365844), Gustavo Ávila (5860646), Sudip Pan (1542133), Gabriel Merino (1413124), María A. Fernández-Herrera (1413115), María G. de los Santos (5860643)   +6 more
core   +1 more source

Synthesis and Biological Evaluation of β-Phenylalanine Derivatives Containing Sulphonamide and Azole Moieties as Antiproliferative Candidates in Lung Cancer Models

Molecules
In this study, a series of novel β-phenylalanine derivatives were synthesised and evaluated for their anticancer activity. The 3-(4-methylbenzene-1-sulfonamido)-3-phenylpropanoic acid (2) was prepared using β-phenylalanine as a core scaffold. The β-amino
Vytautas Mickevičius, Kazimieras Anusevičius, Birutė Sapijanskaitė-Banevič, Ilona Jonuškienė, Linas Kapočius, Birutė Grybaitė, Ramunė Grigalevičiūtė, Povilas Kavaliauskas   +7 more
doaj   +1 more source

Synthesis and Characterization of 1,3,4-Oxadiazoles Derived From 9-Fluorenone

مجلة بغداد للعلوم, 2013
In the present work, 9-fluorenone-2-carboxylic acid methyl ester (1) was prepared from 9-fluorenone-2-carboxylic acid and then converted into the acid hydrazide (2).
Baghdad Science Journal
doaj   +1 more source

Planejamento, síntese e caracterização de derivados do 9,10-bis(5-fenil-1,3,4-oxadiazol-2-IL)Antraceno [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2015Neste trabalho é descrito o planejamento, síntese e caracterização de uma série de novos ...
Ratto Neto, Carlos Alberto
core  

From Bench to Bioactivity: An Integrated Medicinal Development Based on Kinetic and Simulation Assessment of Pyrazolone-Oxadiazole Coupled Benzamide as Promising Inhibitors of Diabetes Mellitus

Pharmaceuticals
Background: In this research work, novel pyrazolone-derived oxadiazole-based benzamide derivatives (1–10) were synthesized through unique and facile synthetic routes.
Manal M. Khowdiary, Shifa Felemban
doaj   +1 more source

1,3‐Dipolar Cycloaddition of Nitroalkanes as a Tool of DOS/LOS‐Like Strategy for the Synthesis of Isoxazoles and Isoxazolines

ChemistryEurope, Volume 4, Issue 9, September 2026.
A broadly applicable synthetic platform based on a DOS/LOS‐like strategy is implemented for the case of sp3‐enriched isoxazole/isoxazoline building blocks. The method is based on a [3+2] cycloaddition of nitroalkanes and various alkenes or alkynes. The utility of the proposed approach is illustrated by the discovery of JAK2‐selective inhibitors.
Bohdan A. Chalyk, Kostiantyn O. Halos, Anastasiia Grynyova, Bohdan S. Sosunovych, Bohdan V. Vashchenko, Oleksandr Zginnyk, Anna Beshtynarska, Nataliia Shliakhtova, Petro Borysko, Angelina V. Biitseva, Konstantin S. Gavrilenko, Dmytro M. Volochnyuk, Oleksandr O. Grygorenko   +12 more
wiley   +1 more source