Results 71 to 80 of about 10,824 (225)
Recent advancements in oxadiazole-based anticancer agents [PDF]
Oxadiazole ring system occupies a significant position among heterocyclic templates for medicinal compounds due to its wide spectrum of biological activities.
Rasool, Irfan +6 more
core +2 more sources
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Planejamento, síntese e caracterização de derivados do 9,10-bis(5-fenil-1,3,4-oxadiazol-2-IL)Antraceno [PDF]
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2015Neste trabalho é descrito o planejamento, síntese e caracterização de uma série de novos ...
Ratto Neto, Carlos Alberto
core
Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz +2 more
wiley +1 more source
Binary‐Solvent‐Programmed Single‐Step Inkjet Printing of Self‐Confined Micro‐Inlaid OLED Arrays
Solvent‐programmed micro‐inlay inkjet printing enables lithography‐free, high‐resolution μ‐OLED arrays in a single step. A thermodynamically tuned 3:1 (w/w) chloroform/dichloroethane blend not only drives interfacial phase separation between the solute and polymers but also stabilizes droplet ejection, forming rim‐confined emissive domains in one pass.
JaeWoo Park +5 more
wiley +1 more source
Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists [PDF]
In this comunication was reported that the manipulation of the oxadiazole scaffold, modifying both substituents at C-3 and C-5, led to the synthesis of a small library of derivatives some of which characterized by a potent FXR antagonistic activity and
Claudia Finamore +5 more
core +1 more source
We described herein the synthesis of novel bis-1,3,4-oxadiazole containing glycine moiety. N-{5-[5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4methoxybenzamide was fully characterized by elemental analysis, FT-IR ...
I. H. R. Tomi +2 more
doaj
Synthesis and characterization of new phthalimides and succinimides substituted with 1,3,4-oxadiazole ring [PDF]
A series of new phthalimides and succinimides connected to 1,3,4-oxadiazole moiety were synthesized via multistep synthesis. The first step involved synthesis of six 5- substituted 2- amino-1,3,4-oxadiazoles by oxidative cyclization of substituted ...
Ahlam Marouf Al-Azzawi +1 more
doaj +1 more source
Unusual backfolded binding poses of BAZ2A bromodomain binders
We identified BAZ2A‐binding compounds assuming a peculiar, almost enclosed, conformation. These molecules pose a basis for the development of potent BAZ2A macrocyclic inhibitors, as performed for other bromodomains.BAZ2A is a large multidomain protein overexpressed in aggressive prostate cancer, where it potentiates migration and invasion of other ...
Andrea Dalle Vedove +5 more
wiley +1 more source
Oxadiazoles are important five membered heterocyclic classes of compounds with 2 azo groups and one oxygen in its ring system. It is widely researched as a lead compound for designing potent bioactive agents.
Mohammad Salam +4 more
core

