Results 71 to 80 of about 12,035 (216)

Recent advancements in oxadiazole-based anticancer agents [PDF]

, 2017
Oxadiazole ring system occupies a significant position among heterocyclic templates for medicinal compounds due to its wide spectrum of biological activities.
Rasool, Irfan, Ahmad, Matloob, Zahoor, Ameer Fawad, Maqbool, Tahir, Khan, Zulfiqar Ali, Mansha, Asim, Aslam, Sana   +6 more
core   +1 more source

Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi‐Target Inhibitors of Cholinesterases and Carbonic Anhydrases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Two novel axially substituted silicon phthalocyanines were synthesized and characterized. Compound 2a exhibited significantly enhanced inhibition of AChE, BChE, hCA I and hCA II, supported by molecular docking and SAR analysis, highlighting its potential as a multifunctional enzyme inhibitor with promising biological activity.
Seda Ünlü, Zeynep Köksal, Kevser Kübra Kırboğa, Fikriye Tuncel Elmalı   +3 more
wiley   +1 more source

Synthesis of new oxadiazole derivatives as potent and selective FXR antagonists [PDF]

, 2019
In this comunication was reported that the manipulation of the oxadiazole scaffold, modifying both substituents at C-3 and C-5, led to the synthesis of a small library of derivatives some of which characterized by a potent FXR antagonistic activity and
Claudia Finamore, Francesco Saverio Di Leva, Carmen Festa, Simona De Marino, Vittorio Limongelli, Angela Zampella   +5 more
core  

A Review on Oxadiazole [PDF]

, 2020
Oxadiazoles are important five membered heterocyclic classes of compounds with 2 azo groups and one oxygen in its ring system. It is widely researched as a lead compound for designing potent bioactive agents.
Mohammad Salam, Namy George, Ashif, Subin Mary Zachariah, Mridula Ramkumar   +4 more
core  

Synthesis, Characterization and Effect of bis-1,3,4Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
  We described herein the synthesis of novel bis-1,3,4-oxadiazole containing glycine moiety. N-{5-[5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4methoxybenzamide was fully characterized by elemental analysis, FT-IR ...
I. H. R. Tomi, A. H. J. Al-Qaisi, Z. H. J. Al-Qaisi   +2 more
doaj  

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 6, Page 729-747, September 2026.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Synthesis and Antimicrobial Activity of Some Derivatives on the Basis (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic Acid Hydrazide

Molecules, 2006
(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (2) was prepared from (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid ethyl ester (1) and 100% hydrazine hydrate.
Elizabeth Has-Schon, Frane Cacic, Mladen Trkovnik, Milan Cacic   +3 more
doaj   +1 more source

Synthesis of Novel Oxadiazole Derivatives, Molecular Properties Prediction and Molecular Docking Studies

Journal of the Turkish Chemical Society, Section A: Chemistry, 2020
In this work, synthesis of novel 1,3,4-oxadiazole derivatives were reported. Good molecular properties profile was predicted for the target compounds. In drug likeness prediction, compound 4b and 8b possess the highest score of 0.31 and 0.33, respectively.
Zühal Kılıç Kurt
doaj   +1 more source

Synthesis and characterization of new phthalimides and succinimides substituted with 1,3,4-oxadiazole ring [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
A series of new phthalimides and succinimides connected to 1,3,4-oxadiazole moiety were synthesized via multistep synthesis. The first step involved synthesis of six 5- substituted 2- amino-1,3,4-oxadiazoles by oxidative cyclization of substituted ...
Ahlam Marouf Al-Azzawi, Hiba Kadhum Yaseen   +1 more
doaj   +1 more source

Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Ligand‐based virtual screening of over five million compounds identifies a thienopyrimidinone hit as a novel allosteric nSMase2 modulator. Structure‐guided optimisation improves inhibitory potency and delivers derivatives with antiviral activity against West Nile virus, expanding the chemical space of nSMase2 inhibitors and supporting host‐directed ...
Hadrián Álvarez‐Fernández, Patricia Mingo‐Casas, Ana‐Belén Blázquez, Flavia Caridi, Miguel A. Martín‐Acebes, María‐Jesús Pérez‐Pérez, Eva‐María Priego   +6 more
wiley   +1 more source