Results 31 to 40 of about 40,557 (208)

Room Temperature Synthesis of Bioactive 1,2,4-Oxadiazoles

International Journal of Molecular Sciences, 2023
1,2,4-Oxadiazole is an essential motif in drug discovery represented in many experimental, investigational, and marketed drugs. This review covers synthetic methods that allow the conversion of different types of organic compounds into 1,2,4-oxadiazole at ambient temperature and the practical application of the latter approaches for the preparation of ...
Sergey V. Baykov, Anton A. Shetnev, Artem V. Semenov, Svetlana O. Baykova, Vadim P. Boyarskiy   +4 more
openaire   +2 more sources

Synthesis, characterization and biological activity of Hg(II), Fe(III) complexes with 1,3,4-oxadiazole, 1,2,4-triazole derivatives from L-methionine

Journal of Saudi Chemical Society, 2020
Four novel heterocyclic1,3,4-oxadiazole, 1,2,4-triazole derivatives, namely: 5-[1-amino-3-(methylsulfanyl)propyl]-1,3,4-oxadiazole-2(3H)-thione (4), 4-amino-5-[1-amino-3-(methylsulfanyl)propyl]-4H-1,2,4-triazole-3-thiol (5), 1-amino-3-[1-amino-3 ...
Khaled Briki, Adil Ali Othman, Mouna Souad Abbassi, Mokhtar Boualem Lahrech   +3 more
doaj   +1 more source

A Family of Energetic Materials Based on 1,2,4-Oxadiazole and 1,2,5-Oxadiazole Backbones With Low Insensitivity and Good Detonation Performance

Frontiers in Chemistry, 2020
Design and synthesis of new compounds with both high detonation performances and good safety properties have always been a formidable task in the field of energetic materials.
Qi Xue, Fu-qiang Bi, Jun-lin Zhang, Zi-jun Wang, Zi-jun Wang, Lian-jie Zhai, Lian-jie Zhai, Huan Huo, Bo-zhou Wang, Sheng-yong Zhang, Sheng-yong Zhang   +10 more
doaj   +1 more source

Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents

BMC Chemistry, 2021
Background 1,2,4-oxadiazole derivatives exhibited significant anti-cancer activity when they were evaluated, against human cancer cell lines. They also showed anti-inflammatory, analgesic, diabetic, immunosuppressive, α,β3-receptor antagonist ...
Ravi Kumar Bommera, Shashikala Kethireddy, Rajeshwar Reddy Govindapur, Laxminarayana Eppakayala   +3 more
doaj   +1 more source

Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters

Molecules, 2011
A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole ...
Aurangzeb Hasan, Shelly Gapil, Noel Francis Thomas   +2 more
doaj   +1 more source

Synthesis and Biological evalution of some substituted 2-dibenzyl amino 1,3,4-oxadiazoles , thiadiazoles and 1,2,4-triazoles [PDF]

مجلة التربية والعلم, 2013
In this paper the synthesis of some substituted 2-dibenzyl 1,3,4-oxadiazole, thiadiazole and 1,2,4-triazoles derived from dibenzyl amine is reported scheme-1.
Khalid Daoud, Shaima Ismmaeel
doaj   +1 more source

Synthesis of a series of novel tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole and 1,3,4-oxadiazole derivatives

Acta Chimica Slovenica, 2016
A series of tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole-5-thiones and 1,3,4-oxadiazole-5-thiones derivatives at lower rim were synthesized by the reaction of 1,2,4-triazole-5-thione and 1,3,4-oxadiazole-5-thione  with 5,11,17,23-tetra-tert ...
Karim Akbari Dilmaghani, Zahra Dono Ghezelbash   +1 more
doaj   +1 more source

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB2 ligands by regioisomeric 1,3,4-oxadiazole ring [PDF]

, 2017
It has been reported that bioisosteric replacement of an 1,2,4-oxadiazole ring by an 1,3,4-oxadiazole ring leads to higher polarity, reduced metabolic degradation by human liver microsomes and reduced interaction with hERG channels.
Schepmann, D., Lueg, C., Corinna Lueg, Vries, H. de, Heitman, L.H., Frehland, B., Henk de Vries, Heimann, D., Wunsch, B., Laura H. Heitman, Bastian Frehland, Dominik Heimann, Bernhard Wünsch, Dirk Schepmann   +13 more
core   +1 more source

A novel method to enhance the thermal stability of dinitroamine-oxadiazole compounds by construction of isomers

Defence Technology
Nitramine-furoxan compounds, as a kind of energetic materials, have attracted great interest due to their outstanding detonation properties. Nevertheless, conventional molecular frameworks incorporating the 1,2,5-oxadiazole usually exhibit low thermal ...
Ziyi Xu, Caijin Lei, Xuezhi Yu, Jie Tang, Wei Hu, Hongwei Yang, Chuan Xiao, Guangbin Cheng   +7 more
doaj   +1 more source

Mass Spectra of 1,2,4-Oxadiazole-5-thiones and 1,2,4-Thiadiazole-5-ones

, 1992
The mass spectra of 3,4-disubstituted-1,2,4-oxadiazole -5(4H)-thione and 3,4-disubstituted-1,2,4-thiadiazole-5(4H) -ones have been studied. The rearrangement of molecular ion of 1,2,4-oxadiazole-5-thiones to 1,2,4-thiadiazole-5-ones was proposed.
Ağırbaş, Hüseyin, AGIRBAS, H, Hikmet A[gbar]irbaş, Doğn Sümengen, SUMENGEN, D   +4 more
core   +1 more source