Electrocyclic Ring‐Opening of 1,2,4‐Oxadiazole[4,5‐a]piridinium Chloride: a New Route to 1,2,4‐Oxadiazole Dienamino Compounds [PDF]
ChemistryOpen, 2019 1,2,4‐Oxadiazole[4,5‐a]piridinium chloride adds nucleophiles to undergo electrocyclic ring opening affording 1,2,4‐oxadiazole dienamino derivatives. These pyridinium salts represent a special class of Zincke salts that are prone to rearrange when treated
Dr. Stefano Carella +2 more
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Recent advances on the nitrogen-rich 1,2,4-oxadiazole-azoles-based energetic materials
Defence Technology, 2022 This review covers recent advances in the synthesis and energetic performance of nitrogen-rich 1,2,4-oxadiazole-azoles-based energetic materials. These materials comprise of 1,2,4-oxadiazole subunit as a key structural motif linked to different nitrogen ...
Wen-Li Cao +4 more
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Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors. [PDF]
J Enzyme Inhib Med ChemA novel series of 1,2,3-triazole/1,2,4-oxadiazole hybrids (7a–o) was developed as dual inhibitors of EGFR/VEGFR-2. Compounds 7a–o were evaluated as antiproliferative agents with Erlotinib as the reference drug.
Mahmoud MA +5 more
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Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease. [PDF]
ACS Med Chem Lett, 2021 Using an iterative structure-activity relationship driven approach, we identified a CNS-penetrant 5-(trifluoromethyl)-1,2,4-oxadiazole (TFMO, 12) with a pharmacokinetic profile suitable for probing class IIa histone deacetylase (HDAC) inhibition in vivo.
Stott AJ +22 more
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In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis. [PDF]
J Enzyme Inhib Med Chem, 2021 The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics.
Deb PK +4 more
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Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract. [PDF]
ACS Omega, 2022 Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective decolonization ...
Pitcher NP +9 more
europepmc +2 more sources
3D-QSAR Studies of 1,2,4-Oxadiazole Derivatives as Sortase A Inhibitors. [PDF]
Biomed Res Int, 2021 Sortase A (SrtA) is an enzyme that catalyzes the attachment of proteins to the cell wall of Gram-positive bacterial membrane, preventing the spread of pathogenic bacterial strains. Here, one class of oxadiazole compounds was distinguished as an efficient
Shakour N +3 more
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5-Nitrotetrazol and 1,2,4-Oxadiazole Methylene-Bridged Energetic Compounds: Synthesis, Crystal Structures and Performances [PDF]
Molecules, 2021 A new structural type for melt cast materials was designed by linking nitrotetrazole ring with 1,2,4-oxadiazole through a N-CH2-C bridge for the first time. Three N-CH2-C linkage bridged energetic compounds, including 3-((5-nitro-2H-tetrazol-2-yl) methyl)
Jiarong Zhang +4 more
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1,2,4-Oxadiazole-Based Bio-Isosteres of Benzamides: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo. [PDF]
Int J Mol Sci, 2021 To discover new compounds with broad spectrum and high activity, we designed a series of novel benzamides containing 1,2,4-oxadiazole moiety by bioisosterism, and 28 benzamides derivatives with antifungal activity were synthesized.
Yang S +7 more
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Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review
Results in Chemistry1,2,4-Oxadiazole derivatives, a prominent class of nitrogen-containing heterocycles, have gained considerable attention recently due to their broad spectrum of biological activities.
Hussam Elddin Nabeih Khasawneh +8 more
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