Results 41 to 50 of about 5,507 (218)

Biologically oriented synthesis of medicines (BIODS) based on heterylpoxid 2,5- disubstituted 1,3,4-oxadiazoles (Part 1)

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
At the present stage of development of medical chemistry, many basic synthetic approaches to the synthesis of 1,3,4-oxadiazole structures are known, which are focused mainly on the principles of combinatorial chemistry with a wide range of biological ...
Yu. V. Karpenko, O. I. Panasenko, Ye. H. Knysh   +2 more
doaj   +1 more source

Potassium (3-Methyl-2-oxido-1,2,5-oxadiazol-4-yl)dinitromethanide

Molbank, 2021
Furoxan derivatives enriched with explosophoric functionalities are promising compounds in the preparation of novel energetic materials. Herein, a previously unknown potassium (3-methyl-2-oxido-1,2,5-oxadiazol-4-yl)dinitromethanide (also referred to as ...
Egor S. Zhilin, Dmitry B. Meerov, Leonid L. Fershtat   +2 more
doaj   +1 more source

DFT Study of Regio- and Stereoselective 13DC Reaction between Diazopropane and Substituted Chalcone Derivatives: Molecular Docking of Novel Pyrazole Derivatives as Anti-Alzheimer’s Agents

Molecules, 2023
In the present work, a combination of experimental and density functional theory (DFT) investigation of the (3+2) cycloaddition reactions of diazopropane with chalcone derivatives was reported. All calculations were performed using several DFT approaches
Sadeq M. Al-Hazmy, Mohamed Oussama Zouaghi, Nasser Amri, Youssef Arfaoui, Ibrahim A. Alhagri, Naceur Hamdi   +5 more
doaj   +1 more source

Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells

Frontiers in Oncology, 2018
Aberrant activation of NF-κB is linked with the progression of human malignancies including hepatocellular carcinoma (HCC), and blockade of NF-κB signaling could be a potential target in the treatment of several cancers.
Chakrabhavi Dhananjaya Mohan, Nirvanappa C. Anilkumar, Shobith Rangappa, Muthu K. Shanmugam, Srishti Mishra, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Atanu Bhattacharjee, Gautam Sethi, Alan Prem Kumar, Alan Prem Kumar, Basappa, Basappa, Kanchugarakoppal S. Rangappa   +13 more
doaj   +1 more source

Therapeutic potential of oxadiazole or furadiazole containing compounds

BMC Chemistry, 2020
As we know that, Oxadiazole or furadi azole ring containing derivatives are an important class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two carbons, one oxygen atom, two nitrogen atoms, and two double bonds is known as ...
Ankit Siwach, Prabhakar Kumar Verma
doaj   +1 more source

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu, Jan Niclas Ludwig, Patrick Wolf Antoni, David Tymann, Max Martin Hansmann   +4 more
wiley   +2 more sources

Synthesis and Antineoplastic Evaluation of Novel Unsymmetrical 1,3,4-Oxadiazoles

, 2016
A series of novel 1,3,4-oxadiazoles was synthesized and evaluated for their cytotoxic activity in in vitro tumor models. Four of the new compounds (2d, 2j, 2k, and 2n) showed growth inhibition in the XTT dye assay.
Giansalvo Pinna (3367052), Valentina Nieddu (3367055), Irene Marchesi (359397), Luca Sanna (3367058), Battistina Asproni (2686828), Gabriele Murineddu (2515921), Gerard A. Pinna (3367061), Luigi Bagella (359398)   +7 more
core   +1 more source

Decoupling Intrinsic Molecular Efficacy From Platform Effects: An Interpretable Machine Learning Framework for Unbiased Perovskite Passivator Discovery

Advanced Science, EarlyView.
This study establishes an interpretable machine learning framework that disentangles the intrinsic molecular efficacy of passivators from experimental platform effects—enabling unbiased, high‐throughput discovery of effective perovskite surface modifiers.
Jing Zhang, Ziyuan Li, Shan Gao, Zhen Zhu, Jing Wang, Xiangmei Duan   +5 more
wiley   +1 more source

Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives

Molecules, 2011
Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods.
Essam Mohamed Sharshira, Nagwa Mohamed Mahrous Hamada   +1 more
doaj   +1 more source

Characterization of Structure, Properties, and Energetic Performance of a 1:1 Ammonium Dinitramide‐3,4‐Diaminofurazan Cocrystal

Propellants, Explosives, Pyrotechnics, EarlyView.
Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz, Uwe Schaller, Thomas Heintz   +2 more
wiley   +1 more source