Results 41 to 50 of about 6,176 (169)
Angewandte Chemie International Edition, EarlyView.We introduce the Aza‐Büchner–Curtius–Schlotterbeck (ABCS) reaction: A mild, catalyst‐free method for homologating aryl imines. Diverging from the traditional BCS mechanism, the diazo intermediate undergoes selective C─C insertion to form an all‐carbon quaternary center.
Simon O. Angerer +6 more
wiley +1 more source
Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives
Molecules, 2011 Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods.
Essam Mohamed Sharshira +1 more
doaj +1 more source
Imidazo[1,2‐b]Pyrazole‐1,2,4‐oxadiazole Linked 1,2,3‐Triazoles: Synthesis, Antibacterial, Biofilm, and In Silico Studies [PDF]
Chem BiodiversA collection of innovative imidazo[1,2‐b]pyrazole–1,2,4‐oxadiazole–1,2,3‐triazole hybrids was conceived via the molecular hybridization of bioactive pharmacophores and produced via a CuAAC methodology. The synthesized compounds exhibited strong antibacterial and antibiofilm properties against gram‐positive bacteria.
Murahari S, Siddoju K.
europepmc +2 more sources
Angewandte Chemie International Edition, EarlyView.Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt +9 more
wiley +1 more source
Oxidative Cyclization Protocol for the Preparation of Energetic 3‑Amino-5‑R‑1,2,4-oxadiazoles
, 2018 An efficient method has been developed for the synthesis of energetic 3-amino-5-R-1,2,4-oxadiazoles via iodobenzene diacetate (IBD)-mediated oxidative cyclization in high yields at ambient temperature.
Jean’ne M. Shreeve (1267290) +3 more
core +1 more source
SYNTHESIS OF MONO-SUBSTITUTED AND SIMMETRICALLY 2, 5-DISUBSTITUTED 1, 3, 4-OXADIAZOLES [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2012 In recent years 1,3,4-oxadiazoles have received considerable attention due to their wide range of biological activities and practical importance. They form an important class of fi ve-member heterocyclic compounds with a variety of derivatives.
Z. Ribcovskaia, F. Macaev
doaj
Molecules, 2013 A facile three step synthesis of a group of N1,N5-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N1,N5-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N1,N5-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. These
Annie Mayence +4 more
doaj +1 more source
Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source
Synthesis and Antineoplastic Evaluation of Novel Unsymmetrical 1,3,4-Oxadiazoles
, 2016 A series of novel 1,3,4-oxadiazoles was synthesized and evaluated for their cytotoxic activity in in vitro tumor models. Four of the new compounds (2d, 2j, 2k, and 2n) showed growth inhibition in the XTT dye assay.
Giansalvo Pinna (3367052) +7 more
core +1 more source
Medical Laboratory Journal, 2021 Background and objectives: Antibiotic resistance is a major public health challenge. The pervasive antibiotic misuse can lead to increased antibiotic resistance.
Nakisa Zarrabi Ahrabi +2 more
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