Results 51 to 60 of about 5,507 (218)

Beyond the stop: Oxadiazole TRIDs restore LRBA protein expression in nonsense-driven primary immunodeficiency

Molecular Therapy: Nucleic Acids
Nonsense mutations are among the genetic causes of LRBA (lipopolysaccharide-responsive beige-like anchor) deficiency, a rare autosomal-recessive immunodeficiency disorder.
Ignazio Fiduccia, Emanuele Vitale, Riccardo Varrica, Davide Ricci, Sefora Marino, Antonino Zito, Andrea Pace, Alain Colige, Michel Moutschen, Yasmin Borutzki, Andrea Bileck, Samuel M. Meier-Menches, Laura Lentini, Ivana Pibiri   +13 more
doaj   +1 more source

Design and Synthesis of N1,N5-bis[4-(5-Alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as Potential Antifungal Prodrugs

Molecules, 2013
A facile three step synthesis of a group of N1,N5-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N1,N5-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N1,N5-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. These
Annie Mayence, Guangdi Wang, Jean J. Vanden Eynde, Nageswara Rao Kode, Tien L. Huang   +4 more
doaj   +1 more source

Oxidative Cyclization Protocol for the Preparation of Energetic 3‑Amino-5‑R‑1,2,4-oxadiazoles

, 2018
An efficient method has been developed for the synthesis of energetic 3-amino-5-R-1,2,4-oxadiazoles via iodobenzene diacetate (IBD)-mediated oxidative cyclization in high yields at ambient temperature.
Jean’ne M. Shreeve (1267290), Damon A. Parrish (1267287), Yongxing Tang (711238), Gregory H. Imler (1902634)   +3 more
core   +1 more source

Synthesis and Characterization of an Azido Nitrofurazanyl Ether: An Energy‐Rich Heterocyclic Plasticizer With a Low Glass Transition Temperature

Propellants, Explosives, Pyrotechnics, EarlyView.
ABSTRACT We report on the synthesis and characterization of 3‐(2‐(2‐azidoethoxy)ethoxy)‐4‐nitro‐1,2,5‐oxadiazole (NFPEG2N3), which is a liquid nitrofurazanyl ether that was designed to be an energy‐rich plasticizer for glycidyl azide polymer (GAP)‐ and nitrocellulose (NC)‐based formulations.
P. Lieber, A. Omlor, U. Schaller, T. M. Klapötke   +3 more
wiley   +1 more source

Synthesis of New Three-Component Derivatives of 1, 3, 4-Oxadiazole and Evaluation of Their In Vitro Antibacterial and Antifungal Properties

Medical Laboratory Journal, 2021
Background and objectives: Antibiotic resistance is a major public health challenge. The pervasive antibiotic misuse can lead to increased antibiotic resistance.
Nakisa Zarrabi Ahrabi, Ali souldozi, Yasin SarveAhrabi   +2 more
doaj  

Unveiling a Redox‐Assisted Electrocatalysis Approach for Efficient Azo‐Based High‐Energy Material Synthesis

SusMat, EarlyView.
A redox‐assisted electrocatalysis strategy is proposed for efficient synthesis of azo‐based energetic material 3,3′‐diamino‐4,4′‐azofurazan (DAAzF). The well‐designed Ni‒Co3O4@CC catalyst enables high‐efficiency electro‐oxidation of DAF and cyclic regeneration of Ce3+/Ce4+ redox pair.
Zilong Cao, Ke Shi, Jiahui Lyu, Dongcheng Jiao, Huizhen Jin, Jia Sun, Bohan Yang, Hongxu Li, Xiang Guo, Guanchao Yin, Xinghui Liu   +10 more
wiley   +1 more source

Unusual backfolded binding poses of BAZ2A bromodomain binders

Acta Crystallographica Section D, EarlyView.
We identified BAZ2A‐binding compounds assuming a peculiar, almost enclosed, conformation. These molecules pose a basis for the development of potent BAZ2A macrocyclic inhibitors, as performed for other bromodomains.BAZ2A is a large multidomain protein overexpressed in aggressive prostate cancer, where it potentiates migration and invasion of other ...
Andrea Dalle Vedove, Giulia Cazzanelli, Vito Giuseppe D'Agostino, Pablo Andres Vargas Rosales, Amedeo Caflisch, Graziano Lolli   +5 more
wiley   +1 more source

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

PREPARAÇÃO DE 1,2,4-OXADIAZOL: SEQUÊNCIA DIDÁTICA APLICADA EM DISCIPLINA DE SÍNTESE ORGÂNICA NA GRADUAÇÃO

Química Nova
1,2,4-oxadiazoles are used in a wide range of applications, including medicinal chemistry and chemistry of materials. However, this kind of oxadiazoles is not usually prepared in an undergraduate organic teaching laboratory.
Juliana L. L. Freire Regueira, Jucleiton J. R. de Freitas, João R. de Freitas Filho   +2 more
doaj   +1 more source