Results 71 to 80 of about 5,960 (212)
Recent Advances in Fluorescent Probes for Imaging Enzyme Activity in NETosis
ChemBioChem, Volume 27, Issue 15, 14 August 2026.Fluorescent probes enable real‐time visualization of neutrophil effector functions. This review summarizes current probe design strategies and emerging tools for imaging key enzymatic activities, with emphasis on mechanisms underlying NETosis, a lytic form of neutrophil extracellular trap (NET) formation. We discuss current limitations, challenges, and
Enebie Ramos Cáceres +2 more
wiley +1 more source
Archiv der Pharmazie, Volume 359, Issue 8, August 2026.This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan +2 more
wiley +1 more source
Synthesis and characterization of 5-aryl-1,3,4-oxadiazole-2(3h)thione derivatives
Journal of Applied Pharmaceutical Research, 2020 1,3,4-oxadiazoles represent a class of heterocyclic five membered compounds it contain two nitrogen and one oxygen of great importance in Pharmaceutical chemistry. This nucleus show four isomeric forms 1,2,4-oxadiazole,1,3,4-oxadiazole, 1,2,5-oxadiazole,
Shailesh Pathak +3 more
doaj +1 more source
Drug Development Research, Volume 87, Issue 5, August 2026.ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq +6 more
wiley +1 more source
The CF3 group attached to N-aryl hydrazone could be activated upon treatment with a suitable base, thus serving as an excellent C1 unit for the assembly of a series of 1,3,4-oxadiazoles by reaction with hydrazides.
Fangyi Li (1566442) +5 more
core +1 more source
Propellants, Explosives, Pyrotechnics, Volume 51, Issue 8, Page 1365-1374, August 2026.ABSTRACT We report on the synthesis and characterization of 3‐(2‐(2‐azidoethoxy)ethoxy)‐4‐nitro‐1,2,5‐oxadiazole (NFPEG2N3), which is a liquid nitrofurazanyl ether that was designed to be an energy‐rich plasticizer for glycidyl azide polymer (GAP)‐ and nitrocellulose (NC)‐based formulations.
P. Lieber +3 more
wiley +1 more source
Oxadiazoles as potential drugs [PDF]
, 2016 Charles University in Prague, Faculty of Pharmacy in Hradec Králové Candidate: Pavlína Dzámová Supervisor: PharmDr. Marta Kučerová, Ph. D. Title of diploma thesis: Oxadiazoles as Potential Drugs Due to the increasing resistence of bacteria and fungi ...
Dzámová, Pavlína
core
Heterocycles from saccharide hydrazones. Part I. Saccharide 1,3,4-oxadiazoles
, 1972 Oxidation, with iodine-mercuric oxide, of acetylated saccharide aroylhydrazones and of aromatic aldehyde hydrazones yields 5-aryl-2-(polyacetoxyalkyl)-1,3,4-oxadiazoles and 2,5-diaryl-1,3,4-oxadiazoles, respectively.
H. El Khadem +5 more
core +1 more source
Synthesis of Dendrimers Containing 1,3,4-Oxadiazoles
, 2016 Synthesis of Dendrimers Containing 1,3,4 ...
Wim Dehaen (496141) +1 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2015 Glycogen phosporylase (GP) is a promising target for the control of glycaemia. The design of inhibitors binding at the catalytic site has been accomplished through various families of glucose-based derivatives such as oxadiazoles.
Marion Donnier-Maréchal +6 more
doaj +1 more source