Results 1 to 10 of about 2,679 (180)

From Synthesis to Synergy: Pyrazole and 1,3,4-Oxadiazole Scaffolds as Versatile Platforms for Multitarget Anticancer Drug Design [PDF]

Journal of Advanced Biomedical and Pharmaceutical Sciences
Pyrazole and 1,3,4-oxadiazole are two key scaffolds in medicinal chemistry. The incorporation of both pharmacophores into a single hybrid molecule has attracted considerable attention because of the potential for synergistic enhancement of biological ...
Arwa Aboukar, Aliaa Mohassab, Heba Hassan, Mamdouh Mohamed   +3 more
doaj   +1 more source

Multifunctional Oxadiazole‐Based Polycatenars: A Pathway to Polar Columnar Phases

Advanced Materials Interfaces, Volume 13, Issue 7, 7 April 2026.
Aromatic core fluorination directs oxadiazole‐based polycatenars into ferroelectric and antiferroelectric columnar phases with supergelation and photo‐responsiveness. ABSTRACT Polar columnar liquid crystals (LCs) offer a promising pathway to nanostructured architectures for next‐generation ferroelectric devices.
Yu Cao, Tejal Nirgude, Jonathan Jende, Alexander Jarosik, Alexey Eremin, Feng Liu, Masafumi Yoshio, Mohamed Alaasar   +7 more
wiley   +1 more source

Synthesis, Characterization and Effect of bis-1,3,4Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
  We described herein the synthesis of novel bis-1,3,4-oxadiazole containing glycine moiety. N-{5-[5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4methoxybenzamide was fully characterized by elemental analysis, FT-IR ...
I. H. R. Tomi, A. H. J. Al-Qaisi, Z. H. J. Al-Qaisi   +2 more
doaj  

Effect of 1,3,4-oxadiazoles on expression of biofilm-associated bap gene in clinical isolates of multidrug-resistant Acinetobacter baumannii

Scientific Reports
The rise of multidrug-resistant (MDR) pathogens, particularly Acinetobacter baumannii, poses a significant threat to global health due to its resistance to multiple antibiotics, biofilm-forming capacity, and associated poor clinical outcomes.
Ali Rahimbakhsh, Mahdi Seyfahmadi, Ali Souldozi, Rakhshan Hakimelahi, Mohammad Yousef Alikhani, Farshid Kafilzadeh   +5 more
doaj   +1 more source

Excimer Formation in Aqueous Solutions of Hosts and Application in Synthesis

ChemPhotoChem, Volume 10, Issue 4, April 2026.
This review explores how host‐mediated excimer formation in water, facilitated by supramolecular confinement enhances photochemical synthesis. By improving solubility, local concentrations, and orientational control, these systems can boost efficiency and selectivity in reactions like photocycloadditions and photodimerizations.
Doğan Akbulut, Florian Friedmann, Gianna Pölderl, Line Næsborg   +3 more
wiley   +1 more source

5-(3-Hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione hemihydrate

IUCrData, 2019
The title 1,3,4-oxadiazole derivative crystallizes as a hemihydrate, C8H6N2O2S·0.5H2O, with the water molecule located on a twofold rotation axis. The 1,3,4-oxadiazole molecule is essentially planar, the r.m.s. deviation of the non-H atoms being 0.0443 Å.
Surayyo Razzoqovna Razzoqova, Shaxnoza Kadirova, Jamshid Mengnorovich Ashurov, Dilnoza Salamovna Rakhmonova, Abdukhakim Ziyaev, Nusrat Agzamovich Parpiev   +5 more
doaj   +1 more source

Structure‐Guided Optimization and Biological Validation of 1,3,4‐Thiadiazole‐Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Ahmet Bugra Aksel, Fikriye Ozgencil, Filiz Bakar‐Ates, Habibe Beyza Gunindi, Alberto Massarotti, Erva Ozkan, Selen Gozde Kaya, Mahmut Gozelle, Yesim Ozkan, Gokcen Eren   +9 more
wiley   +1 more source

Synthesis, Characterization, and Biological Evaluation of Aliphatic‐Substituted Benzimidazole Derivatives: Induction of Apoptosis, Cell Cycle Arrest, and Molecular Docking in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT A new series of aliphatic‐substituted benzimidazole derivatives was synthesized and structurally characterized to evaluate their potential anticancer activity. Among the synthesized compounds, compound 4 exhibited the most potent cytotoxic effects against MCF‐7 and MDA‐MB‐231 breast cancer cell lines, with IC₅₀ values comparable to those of ...
Murat Keser, Çisil Çamlı Pulat, Harika Atmaca, Hakan Akgün, Canan Albay, Emre Menteşe, Hakan Bektaş, Suleyman Ilhan   +7 more
wiley   +1 more source

Synthesis of Some New Heterocyclic Fused Rings Compounds Based on 5-Aryl-1,3,4-Oxadiazole

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
The work includes synthesis and characterization of some new heterocyclic compounds, as flow: The compound (3) (5-(4-chlorophenyl) -2-hydrazinyl-1,3,4-oxadiazole was synthesized by using two methods; the first method includes the direct reaction between
Zahra Mohammed Abbas, Dhuha Faruq Hussain, Raied Mustafa Shakir   +2 more
doaj  

Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents

Acta Pharmaceutica, 2019
In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential antiviral activity, synthesis of compound 1 [2-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetonitrile] was performed through the reaction of cyanoacetic
Albratty Mohammed, El-Sharkawy Karam Ahmed, Alhazmi Hassan Ahmed   +2 more
doaj   +1 more source