Investigation of 1, 3, 4 Oxadiazole Derivative in PTZ-Induced Neurodegeneration: A Simulation and Molecular Approach. [PDF]
J Inflamm Res, 2021 The study investigated the effect 5-[(naphthalen-2-yloxy) methyl]-1,3,4-oxadiaszole2-thiol (B3) in animal model of acute epileptic shock.The pharmacokinetics profile of B3 was checked through SwissADME software. The binding affinities of B3, diazepam, and flumazenil (FLZ) were obtained through Auto Dock and PyRx.
Faheem M +5 more
europepmc +7 more sources
Synthesis and cytotoxic evaluation of some quinazolinone- 5-(4-chlorophenyl) 1, 3, 4-oxadiazole conjugates [PDF]
Research in Pharmaceutical Sciences, 2019 1, 3, 4- Oxadiazoles and quinazolinones are privileged structures with extensive biological activities. On account of reported anticancer activity of them, in this study, a multi-step reaction procedure has been developed for the synthesis of some ...
Farshid Hassanzadeh +4 more
doaj +2 more sources
Synthesis, cytotoxic evaluation, and molecular docking studies of some new 1, 3, 4-oxadiazole-based compounds [PDF]
Research in Pharmaceutical Sciences, 2020 Background and purpose: Oxadiazole-derived compounds have been shown to have a wide range of pharmacological activities. 2, 5-Disubstituted 1, 3, 4-oxadiazole derivatives have occupied a specific place in the design of anti-proliferative agents.
Farshid Hassanzadeh +4 more
doaj +2 more sources
Research Results in PharmacologyIntroduction: 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide is a new selective type II carbonic anhydrase inhibitor with local action through instillation into the eyes. For a complete pharmacokinetic study of this drug, it is necessary to detect
Alexander L. Khokhlov +8 more
doaj +3 more sources
Inhibition of Acetylcholinesterase with Novel 1, 3, 4, Oxadiazole Derivatives: A Kinetic, In Silico, and In Vitro Approach. [PDF]
ACS Omega, 2023 Begum F +11 more
europepmc +2 more sources
مجلة بغداد للعلوم, 2016 In this research various of 2,5-disubstituted 1,3,4-oxadiazole (Schiff base, oxo-thiazolidine , and other compounds) were synthesized from 2,5-di(4,4?- amino-1,3,4-oxadiazole ) which use quently synthesized from mixture of 4-amino benzoic acid and ...
Baghdad Science Journal
doaj +2 more sources
Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives
Journal of Saudi Chemical Society, 2014 In the present investigation, a series of 2(4-pyridyl)-5[(aryl/heteroarylamino)-1-oxoethyl]thio-1,3,4-oxadiazole were synthesized using isonicotinohydrazide and substituted aryl/heteroaryl amines using pyridine as solvent.
Jignesh P Raval
exaly +3 more sources
Syntheses, Evaluation and Characterization of Some 1, 3, 4‐Oxadiazoles as Antimicrobial Agents [PDF]
Journal of Chemistry, 2009 1,3,4‐Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4‐oxadiazole is popularly known for its antimicrobial, anti‐inflammatory, pesticidal and antihypertensive activities etc. It is well known that the synthesis of heterocyclic compounds tend to contain multi‐structure in a molecule.
Niti Bhardwaj +3 more
openaire +4 more sources
Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives [PDF]
E-Journal of Chemistry, 2011 The syntheses of series of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives are described. A total of twelve new compounds were synthesized and characterized by IR, 1H-NMR and Mass spectral data.
P. Panneerselvam, G. Geete Ganesh
doaj +2 more sources
Synthesis and Antimicrobial Screening of Some New Thiazole Substituted 1,3,4-Oxadiazole Derivatives
Chemistry Proceedings, 2021 In the present work, the synthesis and antimicrobial activity of new thiazole substituted 1,3,4-oxadiazole derivatives was achieved. The reaction of different thioamides with ethyl 4-chloro-3-oxobutanoate (4-chloro ethyl acetoacetate) provided ethyl 2-(2-
Siddhant V. Kokate, Sachin V. Patil
doaj +1 more source