Results 11 to 20 of about 7,227 (274)

Syntheses, crystal structures and Hirshfeld surface analysis of 2-(benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole and 2-[(2-chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole

Acta Crystallographica Section E: Crystallographic Communications, 2023
The title compounds were synthesized by alkylation of 5-[(4-dimethylamino)phenyl]-1,3,4-oxadiazole-2-thiol with benzyl chloride or 2-chloro-6-fluorobenzyl chloride in the presence of potassium carbonate.
Rasul Ya. Okmanov, Abdukhakim A. Ziyaev, Azimboy Sh. Abdukarimov, Turdibek T. Toshmurodov, Tursunali S. Kholikov   +4 more
doaj   +1 more source

4,4′-Difluoro-[3,3′-bi(1,2,5-oxadiazole)] 2,2′-Dioxide

Molbank, 2023
1,2,5-Oxadiazole oxides (furoxans) are well known nitric oxide donors; among them, 4-fluorofuroxans have recently been found to be important photoinduced nitric oxide donors. In this research, it was shown that the reaction of 4,4′-dinitro-[3,3′-bi(1,2,5-
Natalia V. Obruchnikova, Oleg A. Rakitin
doaj   +1 more source

N-Phenyl-N-{4-[5-(4-pyridyl)-1,3,4-oxadiazol-2-yl]phenyl}aniline

Acta Crystallographica Section E, 2008
The title compound, C25H18N4O, is a non-planar bipolar ligand containing triphenylamine and 1,3,4-oxadiazole units. In the molecule, the benzene ring, the 1,3,4-oxadiazole ring, and the pyridine ring are twisted slightly with respect to each other ...
Li-Ping Han, Bin Li, Jie Liu
doaj   +1 more source

3-(4-Amino-1,2,5-oxadiazol-3-yl)-4-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole

Molbank, 2014
The title compound 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole (ANFF-1) was synthesized by: (1) by reaction of 3,4-bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole (BNFF-1) with gaseous ammonia in toluene and (2)
Philip Pagoria, Maoxi Zhang, Ana Racoveanu, Alan DeHope, Roman Tsyshevsky, Maija M. Kuklja   +5 more
doaj   +1 more source

Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]

, 2019
This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A., Di Leonardo A., Lentini L., Melfi R., Pace A., Pibiri I., Tutone M.   +6 more
core   +1 more source

Efficient Synthesis of Novel 1,3,4-Oxadiazoles Bearing a 4-N,N-Dimethylaminoquinazoline Scaffold via Palladium-Catalyzed Suzuki Cross-Coupling Reactions

Molecules, 2020
Two series of novel (symmetrical and unsymmetrical) quinazolinylphenyl-1,3,4-oxadiazole derivatives were synthesized using palladium-catalyzed Suzuki cross-coupling reactions. The presented synthetic methodology is based on the use of bromine-substituted
Barbara Wołek, Mateusz Werłos, Magdalena Komander, Agnieszka Kudelko   +3 more
doaj   +1 more source

Synthesis, Characterization, and Biological Evaluation of Aliphatic-Substituted Benzimidazole Derivatives: Induction of Apoptosis, Cell Cycle Arrest, and Molecular Docking in Breast Cancer Cells. [PDF]

Drug Dev Res
ABSTRACT A new series of aliphatic‐substituted benzimidazole derivatives was synthesized and structurally characterized to evaluate their potential anticancer activity. Among the synthesized compounds, compound 4 exhibited the most potent cytotoxic effects against MCF‐7 and MDA‐MB‐231 breast cancer cell lines, with IC₅₀ values comparable to those of ...
Keser M, Çamlı Pulat Ç, Atmaca H, Akgün H, Albay C, Menteşe E, Bektaş H, Ilhan S.   +7 more
europepmc   +2 more sources

Glycogen phosphorylase inhibitor N-(3,5-dimethyl-benzoyl)-N'-(β-Dglucopyranosyl) urea improves glucose tolerance under normoglycemic and diabetic conditions and rearranges hepatic metabolism [PDF]

, 2013
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes.
Bai, Péter, Brunyánszki, Attila, Docsa, Tibor, Gergely, Pál, Hegedűs, Csaba, Kónya, Bálint, Márton, Judit, Nagy, Lilla, Somsák, László, Szántó, Magdolna, Virág, László   +10 more
core   +5 more sources

SYNTHESIS,ANTIBACTERIAL ACTIVITY OF 2-AMINO 5-PHENYL -1,3,4- OXADIAZOLE DERIVATIVES

مجلة بغداد للعلوم, 2008
In the present investigation, five derivatives were synthesized as potential  antimicrobial   agents , The compounds  are : 2-amino 5-phenyl - 1,3,4-  oxadiazole  dithi-ocarbomate, 2-amino 5-( 4-amino- N,N-dimethyl phenyl)-  1,3,4- oxadiazole,    2 ...
Hussain jassem Mohammed
doaj   +1 more source

Synthesis and assessment of the cytotoxic effect of some of 1,4-dihydropyridine derivatives which contain azole moiety [PDF]

Journal of the Serbian Chemical Society, 2021
A number of 1,4-dihydropyridine derivatives (9a–d, 10a–d and 11a–d) were designed and synthesized by the reaction of 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones to 2,6-dibromomethyl-3,5-diethoxycarbonyl-4-(3- -nitrophenyl)-1,4-dihydropyridine.
Ghoorbannejad Saeed, Akbari Dilmaghani Karim, Nikoo Abbas   +2 more
doaj   +1 more source