Results 11 to 20 of about 12,853,470 (222)

Synthesis and cytotoxic evaluation of some quinazolinone- 5-(4-chlorophenyl) 1, 3, 4-oxadiazole conjugates [PDF]

Research in Pharmaceutical Sciences, 2019
1, 3, 4- Oxadiazoles and quinazolinones are privileged structures with extensive biological activities. On account of reported anticancer activity of them, in this study, a multi-step reaction procedure has been developed for the synthesis of some ...
Farshid Hassanzadeh, Hojjat Sadeghi-Aliabadi, Elham Jafari, Azadeh Sharifzadeh, Nasim Dana   +4 more
doaj   +2 more sources

Synthesis, cytotoxic evaluation, and molecular docking studies of some new 1, 3, 4-oxadiazole-based compounds [PDF]

Research in Pharmaceutical Sciences, 2020
Background and purpose: Oxadiazole-derived compounds have been shown to have a wide range of pharmacological activities. 2, 5-Disubstituted 1, 3, 4-oxadiazole derivatives have occupied a specific place in the design of anti-proliferative agents.
Farshid Hassanzadeh, Elham Jafari, Mohammadreza Zarabi, Ghadamali Khodarahmi, Golnaz Vaseghi   +4 more
doaj   +2 more sources

3-(4-Amino-1,2,5-oxadiazol-3-yl)-4-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole

Molbank, 2014
The title compound 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole (ANFF-1) was synthesized by: (1) by reaction of 3,4-bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole (BNFF-1) with gaseous ammonia in toluene and (2)
Philip Pagoria, Maoxi Zhang, Ana Racoveanu, Alan DeHope, Roman Tsyshevsky, Maija M. Kuklja   +5 more
doaj   +2 more sources

Syntheses, crystal structures and Hirshfeld surface analysis of 2-(benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole and 2-[(2-chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole

Acta Crystallographica Section E: Crystallographic Communications, 2023
The title compounds were synthesized by alkylation of 5-[(4-dimethylamino)phenyl]-1,3,4-oxadiazole-2-thiol with benzyl chloride or 2-chloro-6-fluorobenzyl chloride in the presence of potassium carbonate.
Rasul Ya. Okmanov, Abdukhakim A. Ziyaev, Azimboy Sh. Abdukarimov, Turdibek T. Toshmurodov, Tursunali S. Kholikov   +4 more
doaj   +2 more sources

Synthesis of 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives [PDF]

Journal of Drug Delivery and Therapeutics, 2019
Synthesis of a series of various 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives (7a-7u) have been done. Synthesis of a series of intermediates (3a-3c and 5a-5c) have been also done, ethyl-2-phenoxyacetate (3a), ethyl 2-(2, 4-dichlorophenoxy)acetate (3b), ethyl 2-(4-nitrorophenoxy) acetate (3c), 2-phenoxyacetohydrazide (5a), 2-(2, 4-dichlorophenoxy ...
Raghvendra Singh Bhadauria, Neetesh Kumar Sharma, Sanwar Mal Solet   +2 more
openaire   +2 more sources

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 1, 3, 4-OXADIAZOLE DERIVATIVES: A REVIEW OF LITERATURE. [PDF]

International Journal of Advanced Research, 2018
A series of derivatives of 1, 3, 4-oxadiazole having verities of biological activities can be synthesised by various methods. The activities include anticancer, antimicrobial, anti- inflammatory, anti- HIV, anti tubercular, anti diabetic, antifungal etc.
Baijika P, Marathakam, Akash, Midhula C C, Shadiha Saheed, K.   +3 more
core   +3 more sources

Synthesis, Characterization of some New 1, 3, 4-Oxadiazole derivatives based on 4- amino benzoic acid [PDF]

مجلة بغداد للعلوم, 2016
In this research various of 2,5-disubstituted 1,3,4-oxadiazole (Schiff base, oxo-thiazolidine , and other compounds) were synthesized from 2,5-di(4,4?- amino-1,3,4-oxadiazole ) which use quently synthesized from mixture of 4-amino benzoic acid and ...
Baghdad Science Journal
doaj   +2 more sources

The Identification and synthesis of metabolites of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide

Research Results in Pharmacology
Introduction: 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide is a new selective type II carbonic anhydrase inhibitor with local action through instillation into the eyes. For a complete pharmacokinetic study of this drug, it is necessary to detect
Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Valeria A. Panova, Julia A. Efimova, Sergey A. Ivanovskiy, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov   +8 more
doaj   +2 more sources

Synthesis and Characterization of some New 1,3,4-Oxadiazole derivatives based on 4-amino benzoic acid [PDF]

مجلة بغداد للعلوم, 2016
Various of 2,5- disubstituted 1,3,4-oxadiazole (Schiff base, ?- lactam and azo) were synthesized from 2,5-di (4,4?-amino-1,3,4-oxadiazole which usequently synth-esized from mixture of 4- amino benzoic acid and hydrazine arch of polyphosphorus acid.
Baghdad Science Journal
doaj   +2 more sources

Heterocyclic-Based Fungicides: Emerging Strategies for Viable Plant Disease Control. [PDF]

Chem Biodivers
Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Tahlan S, Kaira M, Singh S, Dey H, Pandey KC.   +4 more
europepmc   +2 more sources