Results 41 to 50 of about 8,535 (227)

Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy [PDF]

, 2018
Liver cancer treatments are often hindered by poor drug physicochemical properties, hence there is a need for improvement in order to increase patient survival and outlook.
Al-Shakarchi, W, Alsuraifi, A, Curtis, A, Hoskins, C   +3 more
core   +4 more sources

Synthesis and Biological Activity of 1,3,4-Oxadiazoles Used in Medicine and Agriculture

Applied Sciences, 2022
Biologically active compounds play a key role in the fight against diseases affecting both human and animal living organisms, as well as plants. Finding out about new molecules with a potential biological effect, not yet described in the literature, is ...
Marcin Luczynski, Agnieszka Kudelko
doaj   +1 more source

Efficient one-pot, four-component synthesis of N,N-dibenzyl-N-{1-[5-(3-aryl)-1,3,4-oxadiazol-2-yl]cyclobutyl}amine derivatives from the reaction of (isocyanoimino)triphenylphosphorane, dibenzylamine, an aromatic carboxylic acid and cyclobutanone [PDF]

, 2012
Four-component reaction of cyclobutanone, dibenzylamine and (Nisocyanimino) triphenylphosphorane in the presence of aromatic carboxylic acids proceed smoothly at room temperature and under neutral conditions to afford N,N-dibenzyl-N-{1-[5-(3-aryl)-1,3,
Kazemizadeh Reza Ali, Ramazani Ali, Shajari Nahid   +2 more
core   +1 more source

Poly(1,3,4-oxadiazoles) via aromatic nucleophilic displacement [PDF]

, 1992
Poly(1,3,4-oxadiazoles) (POX) are prepared by the aromatic nucleophilic displacement reaction of di(hydroxyphenyl) 1,3,4-oxadiazole monomers with activated aromatic dihalides or activated aromatic dinitro compounds. The polymerizations are carried out in
Connell, John W., Hergenrother, Paul M., Wolf, Peter   +2 more
core   +1 more source

Predicting melting points of organic molecules : applications to aqueous solubility prediction using the General Solubility Equation [PDF]

, 2015
In this work we make predictions of several important molecular properties of academic and industrial importance to seek answers to two questions: 1) Can we apply efficient machine learning techniques, using inexpensive descriptors, to predict melting ...
McDonagh, James, Mitchell, John B. O., van Mourik, Tanja   +2 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti, Gustavo Salgado Pires, Ana Ryan, Crisamie Regidor, Matthew Hiller, Danilo Sarti, Tríona Ní Chonghaile, Pedro de Sena Murteira Pinheiro, Damir Varešlija, Daniel Alencar Rodrigues   +9 more
wiley   +1 more source

Synthetic marvels in tuberculosis research: An in-depth review of 1,3,4-oxadiazole derivatives as antitubercular agents

European Journal of Medicinal Chemistry Reports
Given the growth in drug-resistant and inactive cases of tuberculosis, it is imperative to develop novel, potent chemicals to treat this deadly illness.
Isha Kapila, Ankita Bharwal, Poonam Sharma, Neeraj Choudhary, Vikrant Abbot   +4 more
doaj   +1 more source

Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

Molecules, 2014
The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as
Mohamed M. El Sadek, Nagwa S. Abd El-Dayem, Seham Y. Hassan, Mohamed A. Mostafa, Galila A. Yacout   +4 more
doaj   +1 more source

Preparation of a number of heterocyclic compounds derived from benzotrazole [PDF]

مجلة التربية والعلم, 2013
In this thesis, a number of heterocyclic compounds with  five-memberd  , such as substituted oxadiazole  , thiadiazole , pyrazole , iso andoline-1,3-dione , also the preparation of  pyrroline and pyrrolidine compounds .      The  ester  compound  (1) was
Mohamed Mohamed, Ahmed Ahmed
doaj   +1 more source