Fluorescence-based proteasome activity profiling [PDF]
, 2012 With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand.
Berkers, C.R. +4 more
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Advanced supersonic technology fuel tank sealants [PDF]
Status of the fuel tank simulation and YF-12A flight tests utilizing a fluorosilicone sealant is described. New elastomer sealant development is detailed, and comparisons of high and low temperature characteristics are made to baseline fluorosilicone ...
Parker, J. A., Rosser, R. W.
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MMP-13 Selective α-sulfone Hydroxamates: a Survey of P1\u27 Heterocyclic Amide Isosteres [PDF]
, 2011 Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups.(1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in an ...
Barta, Thomas E. +3 more
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Synthesis of platinum complexes with 2-(5-perfluoroalkyl-1,2,4-oxadiazol-3yl)-pyridine and 2-(3-perfluoroalkyl-1-methyl-1,2,4-triazole-5yl)-pyridine ligands and their in vitro antitumor activity [PDF]
, 2016 Five new mononuclear Pt(II) complexes with 5-perfluoroalkyl-1,2,4-oxadiazolyl-pyridine and 3-perfluoroalkyl-1,2,4-triazolyl-pyridine ligands are reported.
ATTANZIO, Alessandro +6 more
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ChemMedChemAbstractTuberculosis remains a leading global health threat, exacerbated by the emergence of multi‐drug‐resistant strains. The search for novel therapeutic agents is critical in addressing this challenge. This review systematically summarizes the potential of oxadiazole derivatives as promising candidates in antimycobacterial drug discovery.
openaire +2 more sources
C-(2-Deoxy-D-arabino-hex-1-enopyranosyl)-oxadiazoles: synthesis of possible isomers and their evaluation as glycogen phosphorylase inhibitors [PDF]
, 2021 Bokor, Éva +6 more
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Pharmacophore modelling as useful tool in the lead compounds identification and optimization [PDF]
, 2012 The goal of computer-aided molecular design methods in modern medicinal chemistry is to reduce the overall cost and time associated to the discovery and development of a new drug by identifying the most promising candidates to focus the experimental ...
ALMERICO, Anna Maria +4 more
core
Synthesis of 2-(β-D-glucopyranosylamino)-5-substituted-1,3,4-oxadiazoles for inhibition of glycogen phosphorylase [PDF]
, 2019 Docsa, Tibor +5 more
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Activity Profiling of Nitro-Substituted Di(Hetero)Aryl 1,3,4- and 1,2,4-Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential. [PDF]
Arch Pharm (Weinheim)Šikorová E +9 more
europepmc +1 more source
Novel organic materials and technological advances for photonics [PDF]
, 2002 Blom, Paul W.M., +2 more
core +3 more sources