Results 21 to 30 of about 8,710 (181)

4-[4-(4-Amino-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl]-1,2,5-oxadiazol-3-amine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
The complete molecule of the compound, C(6)H(4)N(8)O(3), is generated by a crystallographic twofold rotation axis that runs through the central ring. The flanking ring is twisted by 20.2 (1)° with respect to the central ring. One of the amino H atoms forms an intra-molecular N-H⋯N hydrogen bond; adjacent mol-ecules are linked by N-H⋯N hydrogen bonds ...
Jia Si-yuan, Bozhou Wang, Xuezhong Fan, Ping Li, Seik Weng Ng   +4 more
openaire   +3 more sources

Preparation of perfluorinated 1,2,4-oxadiazoles [PDF]

, 1982
Fluorinated alkyl or alkylether 1,2,4 oxadiazole compounds are prepared by cyclizing the corresponding alkyl or alkylether imidoyl amidoximes in vacuo or in an inert atmosphere at a temperature within the range of 40 C to 100 C.
Ito, T. I., Kratzer, R. H., Paciorek, K. J. L., Rosser, R. W.   +3 more
core   +1 more source

Ringed spherulitic and undulated textures in the nematic phase of a mixture of trans-4-hexylcyclohexanecarboxylic and benzoic acids

, 2009
We present a polarising optical microscopy study of a liquid-crystal mixture of trans-4-hexylcyclohexanecarboxylic acid (C6) and benzoic acid. Both materials have carboxylic groups that can form dimers through hydrogen bonding. The mixture is nematic and
Sparavigna, Amelia Carolina
core   +1 more source

Synthesis of Fluorinated Bent-Core Mesogens (BCMs) Containing the 1,2,4-Oxadiazole Ring [PDF]

, 2015
New fluorinated bent-core mesogens containing the 1,2,4-oxadiazole or 1,2,4-triazole nucleus have been synthesized taking advantage of the ANRORC (Addition of Nucleophile, Ring-Opening, Ring-Closure) reactivity of 5-perfluoroalkyl-1,2,4-oxadiazoles ...
Amaranatha, Buscemi, Buscemi, Buscemi, Buscemi, Buscemi, Fortuna, Francescangeli, Gallardo, Gallardo, Gallardo, Gortz, Hird, Keith, Link, Lo Celso, Mandracchia, Meunier, Pace, Palumbo, Palumbo, Palumbo, Palumbo, Palumbo, Palumbo Piccionello, Parra, Parra, Pelzl, Pelzl, Pibiri, Prasad, Reddy, Ros, Shanker, Shanker, Speetjens, Terenzi, Terenzi, Torgova, Traskovskis, Tschierske, Tschierske, Van der Plas, Zafiropoulos   +43 more
core   +1 more source

Bifunctional monomers having terminal oxime and cyano or amidine groups [PDF]

, 1981
The preparation of crosslinked 1,2,4-oxadiazole elastomers is described. The technique involves thermally condensing (1) a monomer having the formula H2N(HON)C-R-Q, wherein Q is a triazine ring-forming groups such as nitrile or amidine or a mixture of ...
Kwongs, H., Rosser, R. W., Shalhoub, I. M.   +2 more
core   +1 more source

Mechanistic Paths for the Gold(I)‐Catalyzed Heteroannulation of Salicylic Amides With Apolar Alkynes Explored With Density Functional Theory Calculations

European Journal of Organic Chemistry, EarlyView.
A manifold of catalytic reaction paths can operate in the Au(I)‐catalyzed heteroannulation of salicylic amides and alkynes. However, a subtle initial nucleophilic advantage of N versus O and a kinetic bottleneck at an advanced stage of the mechanistic machinery seems to suffice for the reaction to run on a single path and with exquisite selectivity. We
Ioannis Stylianakis, Evaggelia Vlachou, Carlos Silva López, Antonios Kolocouris   +3 more
wiley   +1 more source

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, EarlyView.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

The dissociation of the Hsp60/pro-Caspase-3 complex by bis(pyridyl)oxadiazole copper complex (CubipyOXA) leads to cell death in NCI-H292 cancer cells [PDF]

, 2017
Cell survival and proliferation are central to carcinogenesis, involving various mechanisms among which those that impede apoptosis are important. In this, the role of the molecular chaperone Hsp60 is unclear since it has been reported that it can be ...
Barone, G., Barone, R., Campanella, C., Cappello, F., Caruso Bavisotto, C., Conway de Macario, E., Giacalone, V., Lo Cascio, F., Macario, A., Marino Gammazza, A., Mocciaro, E., Nikolic, D., Pace, A., Palumbo Piccionello, A., Zummo, G.   +14 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Preparation of crosslinked 1,2,4-oxadiazole polymer [PDF]

, 1981
New crosslinked 1,2,4-oxadiazole elastomers were prepared by thermally condensing a monomer having the formula H2N(HON)C-R-Q, wherein Q is a triazine ring-forming group such as nitrile or amidine or a mixture of such group with amidoxime, or a mixture of
Kwong, H., Rosser, R. W., Shalhoub, I. M.   +2 more
core   +1 more source