Results 21 to 30 of about 5,960 (212)

Synthesis and characterization of new phthalimides and succinimides substituted with 1,3,4-oxadiazole ring [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
A series of new phthalimides and succinimides connected to 1,3,4-oxadiazole moiety were synthesized via multistep synthesis. The first step involved synthesis of six 5- substituted 2- amino-1,3,4-oxadiazoles by oxidative cyclization of substituted ...
Ahlam Marouf Al-Azzawi, Hiba Kadhum Yaseen   +1 more
doaj   +1 more source

A Graphene Acid - TiO₂ Nanohybrid as Multifunctional Heterogeneous Photocatalyst for the Synthesis of 1,3,4-Oxadiazoles

, 2022
The immobilization of TiO2 nanoparticles on graphene acid (GA), a conductive graphene derivative densely functionalized with COOH groups, is presented.
Víctor A. de la Peña O’ Shea (13150095), José Alemán (1447594), Mariam Barawi (1717501), Matías Blanco (1950487), Martina Sciarretta (8697237), Cristina Navío (2351332)   +5 more
core   +1 more source

Design, Synthesis and Anticancer Evaluation of Novel Bis-Thiazol-1,2,4-Triazine Hybrids Contained 1,3,4-Oxadiazoles

, 2022
A new library of bis-thiazol-1,2,4-triazinehybrids having 1,3,4-oxadiazoles (10a–j) has been designed and synthesized. They were examined for their preliminary anticancer properties against four selected human cancer cell lines including SiHa (cervix ...
Suresh Bairi (14007462), Veerachamy Alagarsamy (14007465), Rachamalla Shyam Sunder (14007468)   +2 more
core   +1 more source

Synthesis, characterization and in vivo antitumor effect of new α,β-unsaturated-2,5-disubstituted-1,3,4-oxadiazoles

, 2022
New α,β-unsaturated-2,5-disubstituted-1,3,4-Oxadiazoles (4a–j) and (10a–d) have been prepared in good to excellent yields starting from β-chlorovinyl aldehydes and hydrazide.
M. Fray (12315396), D. Lesur (12315411), R. Abidi (12315417), I. Hamzi (12315402), N. Srairi-Abid (12315408), I. ELBini-Dhouib (12315399), M. Benazza (12315414), T. Barhoumi-Slimi (5028845), R. Doghri (12315405)   +8 more
core   +1 more source

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, EarlyView.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +2 more sources

Oxadiazoles in Medicinal Chemistry

, 2016
Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms.
Eric Wellner (1589959), Jonas Boström (1261665), Anders Hogner (1397881), Alleyn T. Plowright (1684699), Antonio Llinàs (2089249)   +4 more
core   +2 more sources

Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles

, 2017
One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and nitriles was optimized to parallel chemistry. The method was validated on a 141 member library; the desired products were recovered with a high success rate and in ...
Andrey Tolmachev (1514266), Sergey E. Pipko (1514257), Dmytro V. Ushakov (3105645), Alexander V. Grishchenko (3105651), Oleksandr O. Viniychuk (3105648), Anton V. Zhemera (1514260), Anzhelika I. Konovets (1514263), Pavel K. Mykhailiuk (579411), Yurii S. Moroz (119826), Andrey V. Bogolubsky (3105642), Olga A. Zaporozhets (1514269)   +10 more
core   +1 more source

Intramolecular Diels−Alder and Tandem Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Reactions of 1,3,4-Oxadiazoles

, 2016
The scope of intramolecular Diels−Alder and a novel tandem Diels−Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles is disclosed. In the cases examined, the tandem cycloadditions construct three new rings with formation of four new C−C bonds ...
Dale L. Boger (1306542), Gordon D. Wilkie (2990421), Scott Pollack (1436431), Brian S. J. Blagg (1316115), Gregory I. Elliott (2531527), Danielle R. Soenen (2728564), Scott E. Wolkenberg (1639027), Michael M. Miller (1668040)   +7 more
core   +1 more source

Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade

Molecules, 2022
The bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole nuclei have been very attractive to researchers for drug design ...
Rana M. El-Masry, Hanan H. Kadry, Azza T. Taher, Sahar M. Abou-Seri   +3 more
doaj   +1 more source

SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS

Zagazig Journal of Pharmaceutical Sciences, 1993
Synthesis of 2- (6-bromo -2- imidazo [4,5-b] pyridinyl) ethyl -5-( substituted) thío 1,3,4 Oxadiazole derivatives is described. The preparation of 1,3,4 - Oxadiazoles was achieved by cyclization of the corresponding acid hydrazide.
Mohamed Ebeid , Sayed Lashine , Nageh Abou Taleb , Lobna Abdel-Aziz , Magdy Amer   +4 more
doaj   +1 more source