Ammonia–Borane-Mediated Reduction of Nitroalkenes [PDF]
SynOpen, 2020 Ammonia borane (AB) has been successfully employed in the reduction of nitroalkenes. A variety of nitrostyrenes and alkyl-substituted nitroalkenes were chemoselectively reduced to the corresponding nitroalkanes, in short reaction time, with an atom ...
Chiara Faverio +3 more
doaj +3 more sources
Iridium-Catalyzed and pH-Dependent Reductions of Nitroalkenes to Ketones [PDF]
Molecules, 2022 A highly chemoselective conversion of α,β-disubstituted nitroalkenes to ketones is developed. An acid-compatible iridium catalyst serves as the key to the conversion.
Tingting Wang +4 more
doaj +2 more sources
Recent Advances in Asymmetric Organocatalyzed Conjugate Additions to Nitroalkenes
Molecules, 2017 The asymmetric conjugate addition of carbon and heteroatom nucleophiles to nitroalkenes is a very interesting tool for the construction of highly functionalized synthetic building blocks.
Gabriela Guillena +2 more
exaly +3 more sources
Fatty acid nitroalkenes regulate intestinal lipid absorption [PDF]
Journal of Lipid ResearchFatty acid nitroalkenes (NO2-FA) are tissue-protective and anti-inflammatory endogenous lipid mediators. A unique electrophilic character promotes reversible reactions with protein thiols, influencing key cellular functions. Given their generation during
Francisco J. Schopfer +6 more
doaj +2 more sources
Catalytic asymmetric Friedel–Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral Yb(OTf)3–pybox complex [PDF]
Scientific Reports, 2023 Chiral chloro-indeno pybox has served as a new ligand for the Yb(OTf)3-catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with nitroalkenes.
Babak Karimi +3 more
doaj +2 more sources
Stereodivergent Access to Aliphatic Nitro Compounds Bearing Multi‐Contiguous Stereocenters via Sequential Catalysis [PDF]
Advanced ScienceHerein, we report a highly efficient synthesis of aliphatic nitro compounds bearing multi‐contiguous stereocenters in good yields (up to 72%) with excellent diastereo‐ and enantio‐selectivities (up to 12:1 dr, and >99% ee) by combining copper‐catalyzed ...
Jia‐Hao Xie +4 more
doaj +2 more sources
Syn-Propanethial S-Oxide as an Available Natural Building Block for the Preparation of Nitro-Functionalized, Sulfur-Containing Five-Membered Heterocycles: An MEDT Study [PDF]
MoleculesThe regio- and stereoselectivity and the molecular mechanisms of the [3 + 2] cycloaddition reactions between Syn-propanethial S-oxide and selected conjugated nitroalkenes were explored theoretically in the framework of the Molecular Electron Density ...
Mikołaj Sadowski +4 more
doaj +2 more sources
The Puzzle of the New Type of Intermediate in the Course of [2 + 2] Cycloaddition with the Participation of Conjugated Nitroalkenes: MEDT Computational Study [PDF]
MoleculesThe phenomena of regio- and stereoselectivity and the molecular mechanism of the [2 + 2] cycloaddition reaction between (E)-2-arylnitroethenes and the ynamine molecular system were analyzed using wb97xd/6-311 + G(d) (PCM) quantumchemical calculations. It
Radomir Jasiński, Agnieszka Kącka-Zych
doaj +2 more sources
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies [PDF]
Redox Biology, 2023 Nitro fatty acids (NO2-FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide or nitrite-derived reactive species.
Lisa Hong +20 more
doaj +2 more sources
Synthesis of Amino-Acid-Based Nitroalkenes
Organics, 2022 Fatty-acid-based nitroalkenes have recently received great attention because of their bioactivities. On the contrary, peptide- or amino-acid-based nitroalkenes have been scarcely explored so far, although they may exhibit interesting biological ...
Velisaria-Eleni Gerogianni +3 more
doaj +1 more source