Results 1 to 10 of about 79,802 (211)
On Novel Non-Organometallic Aryl Nucleophile in Palladium-Catalyzed Arylation
Chemistry ProceedingsPhenylazocarboxylate is described as a novel non-organometallic aryl nucleophile in palladium-catalyzed arylation.
Didier Villemin +2 more
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Nucleophilic Isocyanation [PDF]
ACS Omega, 2020 Isonitriles are frequently employed as both substrates for organic transformations and ligands for organometallic chemistry. However, despite the wide application of the isonitriles, their synthesis generally depends on the traditional dehydration of N-formamide.
Taiga Yurino, Takeshi Ohkuma
openaire +3 more sources
Systematic Exploration of Privileged Warheads for Covalent Kinase Drug Discovery
Pharmaceuticals, 2022 Kinase-targeted drug discovery for cancer therapy has advanced significantly in the last three decades. Currently, diverse kinase inhibitors or degraders have been reported, such as allosteric inhibitors, covalent inhibitors, macrocyclic inhibitors, and ...
Zheng Zhao, Philip E. Bourne
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Antioxidants, 2022 In laboratory experiments, many electrophilic cytotoxic agents induce cell death accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) depletion.
Petr Mlejnek
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Analysis of the Gas Phase Acidity of Substituted Benzoic Acids Using Density Functional Concepts
Molecules, 2020 A theoretical study of the effect of the substituent Z on the gas phase acidity of substituted benzoic acids ZC6H4COOH in terms of density functional theory descriptors (chemical potential, softness and Fukui function) is presented.
Jorge A. Amador-Balderas +4 more
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Frontiers in Chemistry, 2022 The reactions between 2-chloro-5-nitro pyrimidine with a serie of α-nucleophile derivatives were kinetically evaluated. The kinetic study was carried out in aqueous media and the data shown an unusual split on the Brønsted type-plot, opening a ...
Paola R. Campodónico +2 more
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Kinetics and Reaction Mechanism of Biothiols Involved in SNAr Reactions: An Experimental Study
Frontiers in Chemistry, 2022 Few kinetic parameters, or reaction rates, are known up to date in detail about 1-chloro and 1-fluoro-2,4-dinitrobenzene (ClDNB and FDNB, respectively) with a series of biothiols in aqueous media. These biological nucleophiles with thiol groups have been
Paola R. Campodónico +2 more
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Protocol for synthesis of di- and tri-substituted s-triazine derivatives
MethodsX, 2020 The present protocol describes the synthesis of di and tri-substituted s-triazine derivatives • s-Triazine undergoes sequential nucleophilic substitution reaction but order of nucleophile is very crucial.
Ayman El-Faham +7 more
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Replacement of the Catalytic Nucleophile Aspartyl Residue of Dextran Glucosidase by Cysteine Sulfinate Enhances Transglycosylation Activity [PDF]
, 2013 Dextran glucosidase from Streptococcus mutans (SmDG) catalyzes the hydrolysis of an α-1,6-glucosidic linkage at the nonreducing end of isomaltooligosaccharides and dextran.
Kimura, Atsuo +4 more
core +1 more source
Molecules, 2013 The nucleophilic character and stability of the carbanions vs. alkoxides derived from 2,2,2-trifluoro-1-(9-anthryl)ethanol and 1-(9-anthryl)ethanol containing X electron-releasing and X electron-acceptor substituents attached to C-10, have been studied ...
Francisco Méndez +2 more
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