Results 1 to 10 of about 48,033 (274)
On Novel Non-Organometallic Aryl Nucleophile in Palladium-Catalyzed Arylation
Chemistry ProceedingsPhenylazocarboxylate is described as a novel non-organometallic aryl nucleophile in palladium-catalyzed arylation.
Didier Villemin
exaly +4 more sources
Computational Thermodynamic and Kinetic Analysis of Meisenheimer Intermediate Formation in Aromatic Nucleophilic Addition [PDF]
MoleculesMeisenheimer intermediates provide entry points to nucleophilic aromatic substitution and dearomative functionalization, but productive substrate–nucleophile combinations remain difficult to identify beyond strongly activated aromatic systems.
Cheng Wang +3 more
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Nucleophilic Isocyanation [PDF]
ACS Omega, 2020 Abstract Isonitriles are frequently employed as both substrates for organic transformations and ligands for organometallic chemistry. However, despite the wide application of the isonitriles, their synthesis generally depends on the traditional dehydration of N-formamide.
Taiga Yurino, Takeshi Ohkuma
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Systematic Exploration of Privileged Warheads for Covalent Kinase Drug Discovery
Pharmaceuticals, 2022 Kinase-targeted drug discovery for cancer therapy has advanced significantly in the last three decades. Currently, diverse kinase inhibitors or degraders have been reported, such as allosteric inhibitors, covalent inhibitors, macrocyclic inhibitors, and ...
Zheng Zhao, Philip E. Bourne
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Antioxidants, 2022 In laboratory experiments, many electrophilic cytotoxic agents induce cell death accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) depletion.
Petr Mlejnek
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Analysis of the Gas Phase Acidity of Substituted Benzoic Acids Using Density Functional Concepts
Molecules, 2020 A theoretical study of the effect of the substituent Z on the gas phase acidity of substituted benzoic acids ZC6H4COOH in terms of density functional theory descriptors (chemical potential, softness and Fukui function) is presented.
Jorge A. Amador-Balderas +4 more
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Frontiers in Chemistry, 2022 The reactions between 2-chloro-5-nitro pyrimidine with a serie of α-nucleophile derivatives were kinetically evaluated. The kinetic study was carried out in aqueous media and the data shown an unusual split on the Brønsted type-plot, opening a ...
Paola R. Campodónico +2 more
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Tuning the Nucleophilicity in Cyclopropenylidenes [PDF]
Chemistry – A European Journal, 2008 AbstractCyclopropenylidenes are Hückel aromatic π systems in which one of the ring atoms is a carbene center. Quantum chemical calculations at the density functional level of theory, supplemented by coupled‐cluster calculations, indicate that there is a sizeable energy separation between the lowest‐energy singlet and triplet states of these species ...
Schoeller, Wolfgang +2 more
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Kinetics and Reaction Mechanism of Biothiols Involved in SNAr Reactions: An Experimental Study
Frontiers in Chemistry, 2022 Few kinetic parameters, or reaction rates, are known up to date in detail about 1-chloro and 1-fluoro-2,4-dinitrobenzene (ClDNB and FDNB, respectively) with a series of biothiols in aqueous media. These biological nucleophiles with thiol groups have been
Paola R. Campodónico +2 more
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Protocol for synthesis of di- and tri-substituted s-triazine derivatives
MethodsX, 2020 The present protocol describes the synthesis of di and tri-substituted s-triazine derivatives • s-Triazine undergoes sequential nucleophilic substitution reaction but order of nucleophile is very crucial.
Ayman El-Faham +7 more
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