Results 41 to 50 of about 79,802 (211)

Silver and platinum-catalysed addition of O–H and N–H bonds to allenes [PDF]

, 2014
Transition-metal catalysed nucleophile addition to allenes is a very powerful tool for the synthesis of functionalised molecules containing heteroatoms, heterocycles in the intramolecular version, or allyl derivatives in the intermolecular version.
Munoz-Herranz, Maria
core   +1 more source

Thioether-catalysed tandem synthesis of furans and cyclic ethers or lactones [PDF]

, 2017
Acyclic conjugated ynenediones tethered to an alcohol or carboxylic acid are converted into furanyl-substituted cyclic ethers or lactones in a single step by treatment with the tetrahydrothiophene.
Clark, J. Stephen, Klaus, Verena
core   +1 more source

Concerted nucleophilic aromatic substitutions [PDF]

Nature Chemistry, 2018
Nucleophilic aromatic substitution (SNAr) is one of the most widely applied reaction classes in pharmaceutical and chemical research, providing a broadly useful platform for the modification of aromatic ring scaffolds. The generally accepted mechanism for SNAr reactions involves a two-step addition-elimination sequence via a discrete, non-aromatic ...
Eugene E. Kwan, Yuwen Zeng, Harrison A. Besser, Eric N. Jacobsen   +3 more
openaire   +3 more sources

A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis. [PDF]

, 2016
A long-standing challenge in synthetic chemistry is the development of the transamidation reaction. This process, which involves the conversion of one amide to another, is typically plagued by unfavourable kinetic and thermodynamic factors. Although some
Anthony, Sarah M, Baker, Emma L, Garg, Neil K, Yamano, Michael M, Zhou, Yujing   +4 more
core   +5 more sources

Mechanistic Study of Gold(I)-Catalyzed Intermolecular Hydroamination of Allenes [PDF]

, 2010
The intermolecular hydroamination of allenes occurs readily with hydrazide nucleophiles, in the presence of 3-12% Ph_3PAuNTf_2. Mechanistic studies have been conducted to establish the resting state of the gold catalyst, the kinetic order of the reaction,
Benitez, Diego, Goddard, William A., III, Tkatchouk, Ekaterina, Toste, F. Dean, Wang, Jane Z.   +4 more
core   +1 more source

Solvent-controlled selective transformation of 2-Bromomethyl-2-methylaziridines to functionalized Aziridines and Azetidines [PDF]

, 2012
The reactivity of 2-bromomethyl-2-methylaziridines toward oxygen, sulfur, and carbon nucleophiles in different solvent systems was investigated. Remarkably, the choice of the solvent has a profound influence on the reaction outcome, enabling the ...
Catak, Saron, D'hooghe, Matthias, De Kimpe, Norbert, Goossens, Hannelore, Stanković, Sonja, Tezcan, Meniz, Van Speybroeck, Veronique, Waroquier, Michel   +7 more
core   +1 more source

Formation of New Alkynyl(phenyl)iodonium Salts and Their Use in the Synthesis of Phenylsulfonyl Indenes and Acetylenes

Molecules, 2005
The preparation of phenylsulfonyl indene derivatives and phenylsulfonyl- acetylenes from readily available alkynyl(phenyl)iodonium tetrafluoroborates and triflates was investigated using phenylsulfinate as nucleophile.
A. Varvoglis, A. Savva, C. Kyzas, A. Koumbis   +3 more
doaj   +1 more source

Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate [PDF]

, 2001
Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques(1). A catalytic mechanism, featuring a long-lived oxo-carbenium-ion intermediate, was proposed on the basis of model ...
A Federov, AL Fink, AT Brünger, BA Malcolm, BL Mark, CC Blake, Collaborative Computational Project Number 4, DC Phillips, DE Koshland, DM Chipman, E Holler, FW Ballardie, FW Dahlquist, G Sulzenbacher, GJ Davies, GJ Davies, GN Murshodov, I Matsumura, I Tews, ML Sinnott, NCJ Strynadka, Q Wang, R Kuroki, S Rosenberg, T Rand-Meir, TL Amyes, V Notenboom, WP Burmeister, Z Otwinowski   +28 more
core   +1 more source

Three-dimensional Structure of L-2-Haloacid Dehalogenase from Xanthobacter autotrophicus GJ10 Complexed with the Substrate-analogue Formate [PDF]

, 1997
The L-2-haloacid dehalogenase from the 1,2-dichloroethane degrading bacterium Xanthobacter autotrophicus GJ10 catalyzes the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids.
Barth, Bauke W. Dijkstra, Benning, Bhat, Brünger, Brünger, Collaborative Computational Project, Number 4, Dick B. Janssen, Eisenhaber, Engh, Esnouf, Fetzner, Franken, Furey, Henriëtte J. Rozeboom, Hisano, Ivo S. Ridder, Janssen, Jones, Kabsch, Kawasaki, Kleywegt, Kor H. Kalk, Kraulis, Kurihara, Lamzin, Laskowski, Liu, Liu, Liu, Luzzati, McConnell, Messerschmidt, Murshudov, Navaza, Nicholls, Otwinowski, Read, Ridder, Rossmann, Rüdiger, Taylor, van der Ploeg, Vellieux, Verschueren, Verschueren   +45 more
core   +2 more sources

Synthesis of phosphorothioates using thiophosphate salts

Beilstein Journal of Organic Chemistry, 2006
Reactions of O,O'-dialkyl thiophosphoric acids with alkyl halides, in the presence of a base, provide a direct synthetic route to phosphorothioates via O,O'-dialkyl thiophosphate anion formation. Studies on the reaction of ambident nucleophile ammonium O,
Babak Kaboudin, Fatemeh Farjadian
doaj   +1 more source