Results 1 to 10 of about 22,971 (281)

Ligand-controlled sequential activation enables nickel-catalysed alkyl–alkynyl coupling [PDF]

Nature Communications
Cross-electrophile coupling between unactivated alkyl halides and alkynyl halides has long been challenged by reactivity mismatch and poor chemoselectivity.
Nayeong Kim, Hyeri Jeon, Seungwoo Hong, Won Jun Jang   +3 more
doaj   +2 more sources

Synthesis of α,α‐Difluoroketones via Zinc‐Mediated Cross‐Electrophile Coupling of gem‐Difluoroenol Sulfonates and N‐(acyloxy)phthalimides [PDF]

ChemistryOpen
A zinc‐mediated catalyst‐free cross‐electrophile coupling of gem‐difluoroenol sulfonates with N‐(acyloxy)phthalimides is developed. It efficiently affords diverse α,α‐difluoroketones with broad radical compatibility, good gram‐scale scalability, and ...
Jing Zhao, Li Yang, Xiaohong Wang, Baojian Xiong, Xinmin Li, Huan Yang   +5 more
doaj   +2 more sources

Recyclable dual Z-scheme perovskite/g-C3N4 heterojunction enables photoredox nickel-catalyzed C(sp 2 )–C(sp 3 ) cross-electrophile coupling [PDF]

Nature Communications
Nickel-catalyzed cross-electrophile coupling provides an efficient and cost-effective strategy for constructing C(sp 2 )–C(sp 3 ) bonds, a pivotal transformation for diversifying molecular architectures in pharmaceutical and agrochemical synthesis ...
Rui Wang, Donghao Huo, Shentong Xie, Honghui Ou, Renyi Shi   +4 more
doaj   +2 more sources

Z-REX uncovers a bifurcation in function of Keap1 paralogs

eLife, 2022
Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-à-vis off-target, modifications.
Alexandra Van Hall-Beauvais, Jesse R Poganik, Kuan-Ting Huang, Saba Parvez, Yi Zhao, Hong-Yu Lin, Xuyu Liu, Marcus John Curtis Long, Yimon Aye   +8 more
doaj   +1 more source

Direct Interaction between N-Acetylcysteine and Cytotoxic Electrophile—An Overlooked In Vitro Mechanism of Protection

Antioxidants, 2022
In laboratory experiments, many electrophilic cytotoxic agents induce cell death accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) depletion.
Petr Mlejnek
doaj   +1 more source

Double Attack to Oxidative Stress in Neurodegenerative Disorders: MAO-B and Nrf2 as Elected Targets

Molecules, 2023
Oxidative stress and neuroinflammation play a pivotal role in triggering the neurodegenerative pathological cascades which characterize neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases.
Filippo Basagni, Maria Luisa Di Paolo, Giorgio Cozza, Lisa Dalla Via, Francesca Fagiani, Cristina Lanni, Michela Rosini, Anna Minarini   +7 more
doaj   +1 more source

I₂-Catalyzed/DMSO System for the Oxidation of Se-Se Bond Activated by the Use of SynLED Parallel Photoreactor^®

Chemistry Proceedings, 2022
Among the different green oxidative protocols, I2-catalyzed/DMSO systems have recently received considerable attention due to being greener, efficient, atom-economical, low-cost, and offering the possibility to perform reactions under safe and mild ...
Gloria Pizzoli, Federica D’Ottavio, Cecilia Scimmi, Claudio Santi   +3 more
doaj   +1 more source

Tropylium Ion, an Intriguing Moiety in Organic Chemistry

Molecules, 2023
The tropylium ion is a non-benzenoid aromatic species that works as a catalyst. This chemical entity brings about a large number of organic transformations, such as hydroboration reactions, ring contraction, the trapping of enolates, oxidative ...
Fatima Tuz Zahra, Aamer Saeed, Khansa Mumtaz, Fernando Albericio   +3 more
doaj   +1 more source

N-Sulfenylsuccinimide/phthalimide: an alternative sulfenylating reagent in organic transformations

Beilstein Journal of Organic Chemistry, 2023
In the field of organosulfur chemistry, sulfenylating agents are an important key in C–S bond formation strategies. Among various organosulfur precursors, N-sulfenylsuccinimide/phthalimide derivatives have shown highly electrophilic reactivity for the ...
Fatemeh Doraghi, Seyedeh Pegah Aledavoud, Mehdi Ghanbarlou, Bagher Larijani, Mohammad Mahdavi   +4 more
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Enolates ambushed – asymmetric tandem conjugate addition and subsequent enolate trapping with conventional and less traditional electrophiles

Beilstein Journal of Organic Chemistry, 2023
Metal enolates are useful intermediates and building blocks indispensable in many organic synthetic transformations. Chiral metal enolates obtained by asymmetric conjugate additions of organometallic reagents are structurally complex intermediates that ...
Péter Kisszékelyi, Radovan Šebesta
doaj   +1 more source