Results 21 to 30 of about 22,971 (281)
Pharmaceuticals, 2021 Tranilast (TRL), a synthetic derivative of a tryptophan metabolite, is an anti-allergic drug used to treat bronchial asthma. We investigated how TRL activated the nuclear factor-erythroid 2 p45-related factor 2 (Nrf2)-hemeoxygenase-1 (HO-1) pathway based
Seongkeun Jeong +7 more
doaj +1 more source
, 2022 A nickel-catalyzed denitrogenative cross-electrophile-coupling of benzotriazinones with unactivated alkyl halides (X = Cl, Br, I) in the presence of manganese powder as a reductant has been developed.
Fengze Wang (10452968) +2 more
core +1 more source
Method Development towards Orthogonal Electrophile Delivery [PDF]
, 2021 Redox signaling events mediated by reactive electrophilic species (RES) are key players in several cellular processes. However, the studies on RES have been challenging due to their high reactivity towards numerous nucleophilic groups present in the ...
Wang, Lingxi
core +1 more source
Post-Translational Modification of Proteins Mediated by Nitro-Fatty Acids in Plants: Nitroalkylation
Plants, 2019 Nitrate fatty acids (NO2-FAs) are considered reactive lipid species derived from the non-enzymatic oxidation of polyunsaturated fatty acids by nitric oxide (NO) and related species.
Lorena Aranda-Caño +7 more
doaj +1 more source
Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s Disease
Antioxidants, 2022 Parkinson’s disease (PD) is the second most common neurodegenerative movement disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta.
Manuj Ahuja +9 more
doaj +1 more source
Towards Uncovering the Mechanisms of Electrophile Sensing and Signaling [PDF]
, 2023 Native reactive electrophile species (RES) such as 4-hydroxynonenal (HNE) act as cellular signals through covalent modification of kinetically-privileged electrophile sensor proteins. Research efforts in the field focus mainly on identifying these sensor
Rogg, Chloé
core +1 more source
Journal of Molecular Modeling, 2018 In this work some possibilities for deriving a local electrophilicity are studied. First, we consider the original definition proposed by Chattaraj, Maiti, and Sarkar (J Phys Chem A 107:4973, 2003), in which the local electrophilicity is given by the product of the global electrophilicity, and the Fukui function for charge acceptance is derived by two ...
Robles, Andrés +4 more
openaire +3 more sources
Electrophile-Dependent Alkylations of Lithiated 4‑Alkoxyalk-4-enenitriles
, 2018 Alkylations of acyclic, lithiated 4-alkoxyalk-4-enenitriles are highly diastereoselective with an unusual electrophile-dependent preference. Alkyl halides, sulfur, chlorine, and acyl cyanide electrophiles intercept a series of lithiated 4-alkoxyalk-4 ...
Fraser F. Fleming (1520524) +2 more
core +2 more sources
Electrophilic Fluorination of Organosilanes
ChemInform, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tredwell, M, Gouverneur, V
openaire +3 more sources
Analysis of the Gas Phase Acidity of Substituted Benzoic Acids Using Density Functional Concepts
Molecules, 2020 A theoretical study of the effect of the substituent Z on the gas phase acidity of substituted benzoic acids ZC6H4COOH in terms of density functional theory descriptors (chemical potential, softness and Fukui function) is presented.
Jorge A. Amador-Balderas +4 more
doaj +1 more source