Results 31 to 40 of about 43,957 (340)
Electrophile Modulation of Inflammation: A Two-Hit Approach
Metabolites, 2020 Electrophilic small molecules have gained significant attention over the last decade in the field of covalent drug discovery. Long recognized as mediators of the inflammatory process, recent evidence suggests that electrophiles may modulate the immune ...
James O’Brien, Stacy G. Wendell
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Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease [PDF]
, 2019 BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives.
Antunes, A +7 more
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Journal of Lipid Research, 2013 The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein constituents into mediators that regulate signal transduction.
Sonia R. Salvatore +7 more
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Primary and secondary oxidative stress in Bacillus [PDF]
, 2011 Coping with oxidative stress originating from oxidizing compounds or reactive oxygen species (ROS), associated with the exposure to agents that cause environmental stresses, is one of the prerequisites for an aerobic lifestyle of Bacillus spp. such as B.
Abee, T., Mols, J.M.
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Solvent Effects on Electrophilicity
Journal of the American Chemical Society, 2001 Continuum solvent effect on the electrophilicity index recently proposed by Parr and co-workers (Parr, R. G.; von Szentpaly, L.; Liu, S. J. Am. Chem. Soc. 1999, 121, 1922) is discussed in detail. Solvent effect is introduced using the self-consistent isodensity polarized continuum model (SCI-PCM).
Pérez, Patricia +2 more
openaire +9 more sources
Electrophilic Trapping of Semibenzenes
The Journal of Organic Chemistry, 2022 In this work, we demonstrate how allylative dearomatization of benzyl chlorides can provide direct access to a variety of semibenzenes. These scaffolds behave as highly reactive nucleophiles in the presence of carbocations. In addition, semibenzenes are susceptible to intramolecular rearrangements rendering a broad scope of functionalized arenes.
Boldrini, Cosimo +2 more
openaire +2 more sources
Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles
Molecules, 2011 2-Amino-5-(2-aryl-2H-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles 2-4 have been synthesized by the reaction of 2-aryl-2H-1,2,3-triazole-4-carboxylic acids 1 with thiosemicarbazide. Their reaction with phenacyl (p-substituted phenacyl) bromides led to formation
Kamal F. M. Atta +3 more
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A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR [PDF]
, 2012 The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The
Garelnabi, EAE +7 more
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Angewandte Chemie, EarlyView.This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong +2 more
wiley +2 more sources
Electrochemical oxidative difunctionalization of diazo compounds with two different nucleophiles
Nature Communications, 2023 The difunctionalization of diazo compounds, traditionally with one nucleophile and one electrophile, is a powerful strategy. Here, the authors develop a path of electrochemical oxidative difunctionalization of diazo compounds with two different ...
Dongfeng Yang +9 more
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