Results 51 to 60 of about 43,957 (340)
Advanced Healthcare Materials, EarlyView.Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise +4 more
wiley +1 more source
Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases
Angewandte Chemie, EarlyView.A proximity‐induced, mass‐encoded activity‐based protein profiling (ABPP) approach transfers a MALDI‐detectable α‐cyano‐4‐hydroxycinnamic acid (CHCA) tag directly to active proteases. This tag enables the direct, multiplexed, and quantitative detection of enzyme activity in complex proteomes without enrichment or purification.
Lomane Berthy +20 more
wiley +2 more sources
Substituent Effects on Cyanine Dyes Vary with Position and Chain Length
Advanced Optical Materials, EarlyView.In cyanines, substituent effects vary as a function of substituent position and cyanine length. Electron‐donating‐ and ‐withdrawing groups at meso‐ and α‐positions of 4n+1/4n−1 long cyanines (n = 1, 2, 3…) cause opposing, hypsochromic and bathochromic shifts of the 1st UV–vis absorption bands.
David Dunlop +2 more
wiley +1 more source
Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening
Angewandte Chemie, EarlyView.Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker +3 more
wiley +2 more sources
Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals
Communications Chemistry, 2023 Formaldehyde is a potent toxic electrophile at high concentrations; however its potential regulatory roles remain unknown. Here, the authors report that formaldehyde can react with terminal proline-containing proteins to generate stable 5,5-bicyclic ...
Tobias John +5 more
doaj +1 more source
Quantitative representation of reactivity, selectivity and site activation concepts in organic chemistry [PDF]
, 2004 Indexación: ScieloReactivity, selectivity and site activation are classical concepts in chemistry which are amenable to quantitative representation, in terms of static global, local and non local density response functions.
Contreras, Renato R. +2 more
core
Reactivity of electrophilic cyclopropanes
Pure and Applied Chemistry, 2023 Abstract Cyclopropanes that carry an electron-accepting group react as electrophiles in polar, ring-opening reactions. Analogous reactions at cyclopropanes with additional C2 substituents allow one to access difunctionalized products. Consequently, functionalized cyclopropanes are frequently used building blocks in organic synthesis. The
Eitzinger, Andreas, Ofial, Armin R.
openaire +3 more sources
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
Angewandte Chemie, EarlyView.A catalytic network embedding a formal rearrangement enables the first catalytic enantioselective multicomponent reaction (MCR) of sulfur ylides. In the presence of a bulky chiral phosphoric acid, the reaction combines sulfoxonium ylides, aldehydes and thiols, and affords synthetically versatile β‐hydroxy‐α‐sulfanyl carbonyl compounds in ...
Nicolò Santarelli +10 more
wiley +2 more sources
Synthesis of α-hydroxy-β,β-difluoro-γ-ketoesters via [3,3]sigmatropic rearrangements [PDF]
, 2000 Readily available γ,γ-difluorinated allylic alcohols obtained from trifluoroethanol were esterified efficiently. Exposure to strong base (LDA) afforded the ester enolates, in which chelation both controlled configuration and stabilised against ...
Broadhurst, Michael +3 more
core +1 more source