Results 71 to 80 of about 22,971 (281)
Electrophile-Directed Diastereoselective Alkylation of Prochiral Enediolates
, 2016 Prochiral substituted enediolates undergo diastereoselective alkylation with β-chiral primary iodohydrin derivatives, with selectivities up to 97:3. The most selective reactions occur with dienediolates, but reasonable selectivities can also be obtained ...
Stephen P. Marsden (1748371) +1 more
core +1 more source
Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence
eLife, 2016 Solar irradiation including ultraviolet (UV) light causes tissue damage by generating reactive free radicals that can be electrophilic or nucleophilic due to unpaired electrons.
Eun Jo Du +9 more
doaj +1 more source
Angewandte Chemie, EarlyView.Mixed‐spacer polycarbazole membranes balance conductivity, swelling, and stability by tuning hydration and ionic connectivity. The optimized membrane reaches 184 mS cm−1 hydroxide conductivity and 2.51 W cm−2 peak power density, offering a promising strategy for high‐performance ether‐free AEMs.
Hao Liu +12 more
wiley +2 more sources
Fatty acid nitroalkenes regulate intestinal lipid absorption
Journal of Lipid ResearchFatty acid nitroalkenes (NO2-FA) are tissue-protective and anti-inflammatory endogenous lipid mediators. A unique electrophilic character promotes reversible reactions with protein thiols, influencing key cellular functions. Given their generation during
Francisco J. Schopfer +6 more
doaj +1 more source
Electrophilic Cyclization of Diterpenoids
Chemistry Journal of Moldova, 2006 A review of diterpenoid cyclization initiated by electrophilic reagents is provided. Conventional protonic and Lewis acids are examined along with superacids as initiators of cyclization cascade. An emphasis is placed on the use of cyclization reactions as a tool for the synthesis of compounds with potential practical utility.
Veaceslav Kulciţki +3 more
openaire +2 more sources
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Bis(pinacolato)diboron‐Enabled Ni‐Catalyzed Reductive Arylation/Vinylation of Alkyl Electrophiles
Advanced ScienceHerein, the use of economically and environmentally friendly bis(pinacolato)diboron (B2Pin2) is described as a non‐metallic reductant in mediating Ni‐catalyzed C(sp3)–C(sp2) reductive cross‐coupling of alkyl electrophiles with aryl/vinyl halides.
Deli Sun +4 more
doaj +1 more source
Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals
Communications Chemistry, 2023 Formaldehyde is a potent toxic electrophile at high concentrations; however its potential regulatory roles remain unknown. Here, the authors report that formaldehyde can react with terminal proline-containing proteins to generate stable 5,5-bicyclic ...
Tobias John +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.Sequence‐diverse meso and “near‐meso” oligourea foldamers are reported and exhibit stimulus‐responsive helix screw‐sense control governed by terminal‐group desymmetrization and sequence‐encoded helix stability. ABSTRACT Meso oligoureas are dynamic hydrogen‐bonded foldamers capable of reversible helix polarity inversion but have so far been limited to ...
Naveen Gupta +13 more
wiley +2 more sources
Sulfur‐Bridged Cationic and Neutral [6]Helicenes: Chiral Trityls With Property and Stability Twists
ChemistryEuropeReplacing oxygen or nitrogen bridges with sulfur in cationic [6]helicenes profoundly alters molecular shape, electronic structure, photophysics, chemical reactivity, and configurational stability.
Aurélien Chignac +5 more
doaj +1 more source