Results 61 to 70 of about 43,957 (340)
Advanced Science, EarlyView.In this work, we propose a CMP method for InP using NH4PF₆, which hydrolyzes under In3+ catalysis to form reactive species. These convert InP into low‐binding‐energy fluorides, facilitating removal and dissolution. The process delivers high material removal rates, smooth surfaces, and fluorine passivation that lowers defect density and improves ...
Shigong Fu +5 more
wiley +1 more source
Journal of Lipid ResearchThe enzymatic oxidation of arachidonic acid is proposed to yield trihydroxytetraene species (termed lipoxins) that resolve inflammation via ligand activation of the formyl peptide receptor, FPR2.
Adolf Koudelka +11 more
doaj +1 more source
Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents [PDF]
, 2019 A new series of simplified azasordarin analogs was synthesized using as key steps a Diels–Alder reaction to generate a highly substituted bicyclo[2.2.1]heptane core, followed by a subsequent nitrile alkylation.
Dockendorff, Chris, Wu, Yibiao
core +4 more sources
Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance
Advanced Science, EarlyView.Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes +4 more
wiley +1 more source
Iron‐Photocatalyzed C(sp3)–H Phosphonylation of Alkanes
Angewandte Chemie, EarlyView.Alkyl phosphonates are valuable motifs that can be prepared by phosphonylations of various common functional groups. However, direct phosphonylations of C(sp3)–H bonds are limited to activated positions. Herein, we report an iron‐photocatalyzed phosphonylation of unactivated C(sp3)–H bonds using a novel phosphite radical trap, which is equipped with an
Ya Dong +6 more
wiley +2 more sources
Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence
eLife, 2016 Solar irradiation including ultraviolet (UV) light causes tissue damage by generating reactive free radicals that can be electrophilic or nucleophilic due to unpaired electrons.
Eun Jo Du +9 more
doaj +1 more source
Prolonged and tunable residence time using reversible covalent kinase inhibitors. [PDF]
, 2015 Drugs with prolonged on-target residence times often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking.
Angelina Bisconte +23 more
core
Iron-Catalyzed, Highly Regioselective Synthesis of alpha-Aryl Carboxylic Acids from Styrene Derivatives and CO2 [PDF]
, 2012 The iron-catalyzed hydrocarboxylation of aryl alkenes has been developed using a highly active bench-stable iron(II) precatalyst to give alpha-aryl carboxylic acids in excellent yields and with near-perfect regioselectivity. Using just 1 mol % FeCl2, bis(
Greenhalgh, Mark D., Thomas, Stephen P.
core +1 more source
Advanced Science, EarlyView.We report a palladium‐catalyzed atroposelective cyclization of N‐heterobiaryl triflates with alkynyl boronates to access seven‐membered 1,2‐BN‐bridged biaryls with high yields and excellent enantioselectivity via a cascade DyKAT, cis‐carbopalladation, and 1,2‐migration, which expands the toolbox for axially chiral π‐conjugated boron compounds and opens
Fengya He +6 more
wiley +1 more source
Room‐Temperature Gas‐Phase CO2‐to‐C3 Coupling by a 4f‐Aromatic Cluster
Angewandte Chemie, EarlyView.We engineered a 4f metalla aromatic cluster, PrB2C2−, that enables efficient sequential C−C coupling with CO2 at room temperature, yielding a linear C3 backbone. This system provides a complete theoretical catalytic cycle and establishes a new design principle for lanthanide mediated CO2 activation.
Feng‐Xiang Zhang +7 more
wiley +2 more sources