Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals [PDF]
Frontiers in Aging Neuroscience, 2020 With a lipid-rich environment and elevated oxygen consumption, the central nervous system (CNS) is subject to intricate regulation by lipid-derived electrophiles (LDEs).
Jesse R. Poganik, Yimon Aye
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Catalytic asymmetric synthesis of the alkaloid (+)-myrtine [PDF]
, 2008 A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient
Adriaan J. Minnaard +62 more
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Post-Translational Modification of Proteins Mediated by Nitro-Fatty Acids in Plants: Nitroalkylation
Plants, 2019 Nitrate fatty acids (NO2-FAs) are considered reactive lipid species derived from the non-enzymatic oxidation of polyunsaturated fatty acids by nitric oxide (NO) and related species.
Lorena Aranda-Caño +7 more
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Applications of the Conceptual Density Functional Theory Indices to Organic Chemistry Reactivity [PDF]
, 2016 Indexación: Web of ScienceTheoretical reactivity indices based on the conceptual Density Functional Theory (DFT) have become a powerful tool for the semiquantitative study of organic reactivity.
Domingo, Luis R. +2 more
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On the reduction of 4-oxo-4h-benzopyran-3-carbaldehydes : global and local electrophilicity patterns [PDF]
, 2004 The theoretical global and local electrophilicity patterns of substituted and chelated 4-oxo-4H-benzopyran-3-carbaldehydes (formylchromones) have been evaluated using the electrophilicity index proposed by Parr et al [J. Am. Chem. Soc. 1999, 121, 1922].
Araya Maturana, Ramiro +3 more
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Journal of Molecular Modeling, 2018 In this work some possibilities for deriving a local electrophilicity are studied. First, we consider the original definition proposed by Chattaraj, Maiti, and Sarkar (J Phys Chem A 107:4973, 2003), in which the local electrophilicity is given by the product of the global electrophilicity, and the Fukui function for charge acceptance is derived by two ...
Robles, Andrés +4 more
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Analysis of the Gas Phase Acidity of Substituted Benzoic Acids Using Density Functional Concepts
Molecules, 2020 A theoretical study of the effect of the substituent Z on the gas phase acidity of substituted benzoic acids ZC6H4COOH in terms of density functional theory descriptors (chemical potential, softness and Fukui function) is presented.
Jorge A. Amador-Balderas +4 more
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The role of inflammation in age-related disease. [PDF]
, 2013 The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD.
Augustine, Alison Deckhut +9 more
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Electrophiles against (Skin) Diseases: More Than Nrf2
Biomolecules, 2020 The skin represents an indispensable barrier between the organism and the environment and is the first line of defense against exogenous insults. The transcription factor NRF2 is a central regulator of cytoprotection and stress resistance.
Paulina Hennig +3 more
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Integrated stress response of Escherichia coli to methylglyoxal : transcriptional readthrough from the nemRA operon enhances protection through increased expression of glyoxalase I [PDF]
, 2013 © 2013 The Authors.
Booth, Ian R +4 more
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