Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals [PDF]
Frontiers in Aging Neuroscience, 2020 With a lipid-rich environment and elevated oxygen consumption, the central nervous system (CNS) is subject to intricate regulation by lipid-derived electrophiles (LDEs).
Jesse R. Poganik, Yimon Aye
doaj +8 more sources
A Ball Milling Enabled Cross-Electrophile Coupling [PDF]
, 2021 The nickel-catalyzed cross-electrophile coupling of aryl (pseudo)halides and alkyl (pseudo)halides enabled by ball-milling is herein described. Under a mechanochemical manifold, the reductive C–C bond formation was achieved in the absence of bulk solvent
Jamie, Leitch +3 more
core +4 more sources
Should I Stay or Should I Go-Leveraging an Overlooked Feature of Click-to-Release Chemistry for Affinity Labeling. [PDF]
Angew Chem Int Ed EnglClick‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Kern D +9 more
europepmc +3 more sources
Dual Nickel/Photoredox-Catalyzed Regio- and Enantioselective Alkenylation of Epoxides. [PDF]
Adv Sci (Weinh)Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Lan H, Jin S, Xu ZD, Li G, Wang D.
europepmc +2 more sources
Nickel-Catalyzed Electrochemical Reductive Cross-Electrophile Coupling of Alkylpyridinium Salts and Aryl Halides [PDF]
, 2022 An electrochemically driven, nickel-catalyzed cross-electrophile coupling reaction of alkylpyridinium salts and aryl halides is reported. High-throughput experimentation (HTE) was employed for rapid reaction optimization and evaluation of a broad scope ...
Jessica, Sampson +5 more
core +1 more source
A Widely Applicable Dual-Catalytic System for Cross-Electrophile Coupling [PDF]
, 2020 A new dual catalytic system for cross-electrophile coupling reactions between aryl and alkyl halides that features a Ni catalyst, a Co co-catalyst, and a mild homogeneous reductant, is described.
David, Charboneau +4 more
core +2 more sources
Cross-Electrophile Coupling of Alcohols with Aryl and Vinyl Halides [PDF]
, 2021 Although alcohols represent one of the largest pools of commercially available alkyl substrates, approaches to di-rectly utilize them in cross-coupling and cross-electrophile coupling are limited.
Daniel, Weix +5 more
core +1 more source
Carbonylative Cross-Electrophile Coupling Between Aryl Bromides and Aryl Triflates Enabled by Palladium and Rhodium Cooperative Catalysis [PDF]
, 2021 Ketones are among the most useful functional groups in organic synthesis. Here, we report the first carbonylative cross-electrophile coupling reaction that utilize carbon monoxide gas as the carbonyl source. The use of Pd/Rh cooperative catalysis enables
Zhong, Lian +4 more
core +2 more sources
A monometallic approach for the C(sp2)-C(sp2) cross-electrophile coupling: Bypassing the demand of transmetalation [PDF]
, 2023 Transition metal catalyzed cross-coupling is a versatile tool for the construction of (hetero)biaryl scaffolds. However, the cross-electrophile coupling using abundant (hetero)aryl halides and pseudohalides is still in its infancy.
Sagnik, Chatterjee +8 more
core +2 more sources
An Asymmetric sp3–sp3 Cross-Electrophile Coupling Using Biocatalysis [PDF]
, 2022 The catalytic asymmetric construction of Csp3–Csp3 bonds remains one of the foremost challenges in organic synthesis. Metal-catalyzed cross-electrophile couplings have emerged as a powerful tool for C–C bond formation.
Jingzhe, Cao +13 more
core +2 more sources