Results 41 to 50 of about 3,217 (192)
Amino Imidate Catalyzed Asymmetric Michael Reactions of Ketones and Nitroalkenes
SynOpen, 2022 The efficiency of an amino imidate organocatalyst was evaluated in the Michael reaction of ketones with nitroalkenes. tert-Butyl l-proline imidate was found to be a syn-selective catalyst, generating products with moderate to good enantioselectivities ...
Bohdan Sosunovych +2 more
doaj +1 more source
Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis
European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2012 The highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes, promoted by binaphthyl-modified chiral bifunctional organocatalysts is described.
Saet Byeol Woo, Dae Young Kim
doaj +1 more source
Oxidative [3+2]-annulation of nitroalkenes and azolium ylides in the presence of Cu(II): efficient synthesis of [5,5]-annulated N-fused heterocycles [PDF]
, 2021 A facile synthesis of [5,5]-annulated N-fused heterocycles – pyrrolo[2,1-b]thiazoles and pyrrolo[1,2-b]indazoles via Cu(II)-mediated oxidative [3+2]-annulation between nitroalkenes and azolium ylides was developed.
Andrey A., Tabolin +2 more
core +2 more sources
Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.An enantioselective Mannich reaction using barbituric acids as nucleophiles provides access to chiral heterocycles bearing quaternary stereocenters. The transformation is catalyzed by a bifunctional thiourea with high selectivity. An immobilized catalyst enables recycling and application under continuous‐flow conditions, offering an efficient and ...
Rodrigo Sánchez‐Molpeceres +4 more
wiley +1 more source
The Diarylprolinol Silyl Ethers: After 20 Years Still Opening New Doors in Asymmetric Catalysis
Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.Catalysis Rules! The year 2025 marks the 20th anniversary of diarylprolinol silyl ethers in asymmetric organocatalysis. During the first decade after their discovery, these catalysts have been established as one of the most versatile tools in aminocatalysis. Although now considered mature, recent years have witnessed renewed innovation.
Enrico Marcantonio +2 more
wiley +2 more sources
Rauhut-Currier type homo- and heterocouplings involving nitroalkenes and nitrodienes
, 2010 Reaction of nitroalkenes or nitrodienes with methyl vinyl ketone (MVK) or acrylate in the presence of the imidazole-LiCl catalyst system provides Rauhut-Currier (vinylogous Morita-Baylis-Hillman) adducts in moderate yield.
DADWAL, M +4 more
core +2 more sources
The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors
Protein Science, Volume 35, Issue 7, July 2026.Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley +1 more source
Fast Reduction of Nitroalkenes Into Nitroalkanes Under Continuous‐Flow Chemical Conditions
European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.Flow chemical synthesis was employed for the reduction of nitroalkenes to the corresponding nitroalkanes using sodium borohydride as the reducing agent. The reaction proceeds in only 150 s, affording products from good‐to‐excellent yields (61–96%). Herein, we describe an efficient and rapid continuous‐flow reduction of nitroalkenes to nitroalkanes. The
Iqra Munir +3 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.This work describes the synthesis of lactose‐ and glucose‐derived chiral ligands and their application in the catalytic enantioselective Friedel–Crafts alkylation of indole with a series of trans‐β‐nitrostyrenes. The optimal ligand was an acetate protected, lactose‐derived pyridyl imine and its zinc complex afforded ees up to 93% and yields up to 93 ...
Sandra Bulawa +2 more
wiley +1 more source