Results 51 to 60 of about 2,206 (129)

Stereoselective amine-thiourea-catalysed sulfa-Michael/nitroaldol cascade approach to 3,4,5-substituted tetrahydrothiophenes bearing a quaternary stereocenter

open access: yesBeilstein Journal of Organic Chemistry, 2016
An investigation on the stereoselective cascade sulfa-Michael/aldol reaction of nitroalkenes and commercially available 1,4-dithiane-2,5-diol to 3,4,5-substituted tetrahydrothiophenes, bearing a quaternary stereocenter, is presented.
Sara Meninno   +4 more
doaj   +1 more source

Catalytic Strategies for Amide‐Based Michael Additions: Advances and Perspectives

open access: yesJournal of Chemistry, Volume 2026, Issue 1, 2026.
The Michael addition is a cornerstone transformation in organic synthesis, enabling efficient C–C and C–heteroatom bond formation. Traditionally, α,β‐unsaturated carbonyl compounds such as enones and esters have dominated as Michael acceptors, whereas α,β‐unsaturated amides remain underutilized due to their strong resonance stabilization and low ...
Muhammad Naufal   +6 more
wiley   +1 more source

Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products

open access: yesEuropean Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.
A revolution is underway in the synthesis of amidines with new methods unlocking complex, highly substituted amidines or closely related derivatives such as N‐sulfonyl amidines. This review surveys recent advances in amidines and related compounds, including methods to install them and bioactive molecules prominently featuring the amidine functionality.
Wyatt R. Swift‐Ramirez   +1 more
wiley   +1 more source

LMCT‐Driven Iron Photocatalysis: Mechanistic Insights and Synthetic Applications

open access: yesChemistry – A European Journal, Volume 31, Issue 58, October 16, 2025.
LMCT‐driven iron photocatalysis: This review discusses recent developments in ligand‐to‐metal charge transfer (LMCT)‐driven iron photocatalysis, emphasizing mechanistic insights and diverse synthetic applications. By classifying Fe(III)–L bond homolysis pathways, it highlights iron's potential as a sustainable alternative to precious metals for radical‐
Amrita Chaudhuri   +4 more
wiley   +1 more source

A Decade of Progress: Review of the Synthesis of Dibenzo[b,f]oxepines

open access: yesThe Chemical Record, Volume 25, Issue 10, October 2025.
This review summarizes recent advances in dibenzo[b,f]oxepine synthesis, highlighting medicinal and materials applications. It discusses classical and modern methods, including cross‐coupling, intramolecular cyclizations, and diversification strategies, emphasizing efficiency, selectivity, and sustainability. Emerging trends such as greener approaches,
Gabriel Pereira da Costa   +6 more
wiley   +1 more source

Bifunctional Organocatalysts and Brønsted Bases in Cooperative Catalysis for the Asymmetric [4 + 2] Cycloaddition of In Situ‐Generated Dienes from Isochromane‐3,4‐Diones with Nitroalkenes

open access: yesAdvanced Synthesis &Catalysis, Volume 367, Issue 18, September 29, 2025.
Herein, the first asymmetric [4+2] cycloaddition is reported, utilizing in situ‐generated dienes from isochromane‐3,4‐diones and nitroalkenes, catalyzed by a bifunctional thiourea organocatalyst and Brønsted base cocatalysts, yielding highly enantioselective bridged and spiro lactones, with further investigations into novel reactivity and product ...
Mohammad Sadeq Mousavi   +2 more
wiley   +1 more source

A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

open access: yesMolecules, 2014
An efficient method for the synthesis of a variety of pyrimidine derivatives 3a–t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a–k as Michael acceptor using an aqueous medium and diethylamine is described.
Hany J. Al-Najjar   +6 more
doaj   +1 more source

Synthesis, X-ray Diffraction, Thermogravimetric and DFT Analyses of Pyrimidine Derivatives

open access: yesMolecules, 2014
An eco-benign synthesis of pyrimidine derivatives 2a,b containing different functional groups with different electronic character starting from nitroalkenes 1a and 2b has been described.
Assem Barakat   +7 more
doaj   +1 more source

Visible Light‐Mediated Reactions of β‐Nitroalkenes

open access: green, 2022
Sudheesh T. Sivanandan   +3 more
openalex   +2 more sources

Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2

open access: yesCommunications Chemistry
The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (Mpro) represents one of the most attractive targets for the development of antiviral drugs.
Francisco J. Medrano   +17 more
doaj   +1 more source

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