Results 51 to 60 of about 3,335 (198)

Nitroalkylation Mediated by Nitro‐Fatty Acids Is Involved in Key Physiological Processes During Arabidopsis thaliana Development

Plant, Cell &Environment, EarlyView.
ABSTRACT Nitro‐fatty acids (NO2‐FAs) are potent electrophiles that react with nucleophilic residues in proteins (cysteines, histidines and lysines) via a process known as nitroalkylation. This reversible post‐translational modification (PTM) functions as a selective signalling mechanism by modulating the structure, transport, and catalysis of target ...
Lorena Aranda‐Caño, Raquel Valderrama, Mounira Chaki, Juan Carlos Begara‐Morales, José Rafael Pedrajas, Manuel Melguizo, Matín Moret, Aureliano Bombarely, Francisco Luque, Juan Bautista Barroso   +9 more
wiley   +1 more source

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

Nickel-catalysed asymmetric Michael Additions of 2-acetylazaarenes to nitroalkenes.

, 2015
Azaarenes are of widespread chemical significance, being present in numerous chiral, biologically active natural products, and serving as building blocks for the discovery of new medicines, agrochemicals, and functional molecules.
Simpson, Alain
core   +2 more sources

Recent Advances in AIE‐Active Polymers for Explosives Detection

PhotoAggregate, Volume 1, Issue 1, October 2026.
From linear polymers to porous frameworks and supramolecular assemblies, AIE has enabled highly emissive polymeric platforms for explosive detection. This review summarizes recent advances in AIE‐active polymers, highlighting structure–property relationships and sensing mechanisms.
Ming Hui Chua, Kang Le Osmund Chin, Bryan Yat Kit Hui, Ran Tao, Kok Chan Chong, Jianwei Xu   +5 more
wiley   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Amino-Catalyzed Reactions of Aldehydes with Chiral Nitroalkenes

Organic Letters, 2021
Chiral nitroalkenes are used for the first time in Michael additions of aldehydes, catalyzed by pyrrolidine derivatives. They yield the same major stereoisomer with either (S)-proline or (R)-proline, but this asymmetric induction does not overcome the effect of sterically more congested catalysts.
Víctor Cascales, Héctor Carneros, Alejandro Castro-Alvarez, Anna M. Costa, Jaume Vilarrasa   +4 more
openaire   +3 more sources

A New Insight into the Molecular Mechanism of the Reaction between 2-Methoxyfuran and Ethyl (Z)-3-phenyl-2-nitroprop-2-enoate: An Molecular Electron Density Theory (MEDT) Computational Study

Molecules
The molecular mechanism of the reaction between 2-methoxyfuran and ethyl (Z)-3-phenyl-2-nitroprop-2-enoate was investigated using wb97xd/6-311+G(d,p)(PCM) quantum chemical calculations.
Mikołaj Sadowski, Ewa Dresler, Aneta Wróblewska, Radomir Jasiński   +3 more
doaj   +1 more source

Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease

Redox Biology, 2023
Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and mortality rates worldwide. Despite being monogenic, SCD patients display a plethora of disease-associated complications including anemia, oxidative stress, sterile ...
Fabliha A. Chowdhury, Nicole Colussi, Malini Sharma, Katherine C. Wood, Julia Z. Xu, Bruce A. Freeman, Francisco J. Schopfer, Adam C. Straub   +7 more
doaj   +1 more source

Barbituric Acids as Nucleophiles in Enantioselective Mannich Reactions: Organocatalytic Access to Quaternary Aminopyrazolone–Barbiturate Adducts

Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
An enantioselective Mannich reaction using barbituric acids as nucleophiles provides access to chiral heterocycles bearing quaternary stereocenters. The transformation is catalyzed by a bifunctional thiourea with high selectivity. An immobilized catalyst enables recycling and application under continuous‐flow conditions, offering an efficient and ...
Rodrigo Sánchez‐Molpeceres, Mónica Llorente‐Pérez, Laura Martín, Alicia Maestro, José M. Andrés   +4 more
wiley   +1 more source

Synthesis of non-racemic 4-nitro-2-sulfonylbutan-1-ones via Ni(II)-catalyzed asymmetric Michael reaction of β-ketosulfones

Beilstein Journal of Organic Chemistry, 2019
Functionally substituted sulfones with stereogenic centers are valuable reagents in organic synthesis and key motifs in some bioactive compounds. The asymmetric Michael addition of β-ketosulfones to conjugated nitroalkenes in the presence of Ni(II ...
Alexander N. Reznikov, Anastasiya E. Sibiryakova, Marat R. Baimuratov, Eugene V. Golovin, Victor B. Rybakov, Yuri N. Klimochkin   +5 more
doaj   +1 more source