Results 51 to 60 of about 2,206 (129)
An investigation on the stereoselective cascade sulfa-Michael/aldol reaction of nitroalkenes and commercially available 1,4-dithiane-2,5-diol to 3,4,5-substituted tetrahydrothiophenes, bearing a quaternary stereocenter, is presented.
Sara Meninno +4 more
doaj +1 more source
Catalytic Strategies for Amide‐Based Michael Additions: Advances and Perspectives
The Michael addition is a cornerstone transformation in organic synthesis, enabling efficient C–C and C–heteroatom bond formation. Traditionally, α,β‐unsaturated carbonyl compounds such as enones and esters have dominated as Michael acceptors, whereas α,β‐unsaturated amides remain underutilized due to their strong resonance stabilization and low ...
Muhammad Naufal +6 more
wiley +1 more source
Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products
A revolution is underway in the synthesis of amidines with new methods unlocking complex, highly substituted amidines or closely related derivatives such as N‐sulfonyl amidines. This review surveys recent advances in amidines and related compounds, including methods to install them and bioactive molecules prominently featuring the amidine functionality.
Wyatt R. Swift‐Ramirez +1 more
wiley +1 more source
LMCT‐Driven Iron Photocatalysis: Mechanistic Insights and Synthetic Applications
LMCT‐driven iron photocatalysis: This review discusses recent developments in ligand‐to‐metal charge transfer (LMCT)‐driven iron photocatalysis, emphasizing mechanistic insights and diverse synthetic applications. By classifying Fe(III)–L bond homolysis pathways, it highlights iron's potential as a sustainable alternative to precious metals for radical‐
Amrita Chaudhuri +4 more
wiley +1 more source
A Decade of Progress: Review of the Synthesis of Dibenzo[b,f]oxepines
This review summarizes recent advances in dibenzo[b,f]oxepine synthesis, highlighting medicinal and materials applications. It discusses classical and modern methods, including cross‐coupling, intramolecular cyclizations, and diversification strategies, emphasizing efficiency, selectivity, and sustainability. Emerging trends such as greener approaches,
Gabriel Pereira da Costa +6 more
wiley +1 more source
Herein, the first asymmetric [4+2] cycloaddition is reported, utilizing in situ‐generated dienes from isochromane‐3,4‐diones and nitroalkenes, catalyzed by a bifunctional thiourea organocatalyst and Brønsted base cocatalysts, yielding highly enantioselective bridged and spiro lactones, with further investigations into novel reactivity and product ...
Mohammad Sadeq Mousavi +2 more
wiley +1 more source
An efficient method for the synthesis of a variety of pyrimidine derivatives 3a–t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a–k as Michael acceptor using an aqueous medium and diethylamine is described.
Hany J. Al-Najjar +6 more
doaj +1 more source
Synthesis, X-ray Diffraction, Thermogravimetric and DFT Analyses of Pyrimidine Derivatives
An eco-benign synthesis of pyrimidine derivatives 2a,b containing different functional groups with different electronic character starting from nitroalkenes 1a and 2b has been described.
Assem Barakat +7 more
doaj +1 more source
Visible Light‐Mediated Reactions of β‐Nitroalkenes
Sudheesh T. Sivanandan +3 more
openalex +2 more sources
The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (Mpro) represents one of the most attractive targets for the development of antiviral drugs.
Francisco J. Medrano +17 more
doaj +1 more source

