Results 51 to 60 of about 3,217 (192)

Amino-Catalyzed Reactions of Aldehydes with Chiral Nitroalkenes

Organic Letters, 2021
Chiral nitroalkenes are used for the first time in Michael additions of aldehydes, catalyzed by pyrrolidine derivatives. They yield the same major stereoisomer with either (S)-proline or (R)-proline, but this asymmetric induction does not overcome the effect of sterically more congested catalysts.
Víctor Cascales, Héctor Carneros, Alejandro Castro-Alvarez, Anna M. Costa, Jaume Vilarrasa   +4 more
openaire   +3 more sources

Phase‐Transfer‐Catalyzed Interrupted Barton–Zard Reaction Between Electron‐Deficient Indoles and Benzophenone‐Derived Isocyanides

European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.
A cascade reaction under phase‐transfer conditions between 3‐nitro indoles and isocyanomethylene dibenzenes affords the construction of pyrrolo[3,4‐b]indole cores. Control experiments provide insight into moderate product yields and clarify why the reaction is not amenable to asymmetric induction. A cascade reaction enabling the construction of pyrrolo[
Ana Mikleušević, Ines Bašić, Mateja Matišić, Josip Rešetar, Matija Gredičak   +4 more
wiley   +1 more source

A New Insight into the Molecular Mechanism of the Reaction between 2-Methoxyfuran and Ethyl (Z)-3-phenyl-2-nitroprop-2-enoate: An Molecular Electron Density Theory (MEDT) Computational Study

Molecules
The molecular mechanism of the reaction between 2-methoxyfuran and ethyl (Z)-3-phenyl-2-nitroprop-2-enoate was investigated using wb97xd/6-311+G(d,p)(PCM) quantum chemical calculations.
Mikołaj Sadowski, Ewa Dresler, Aneta Wróblewska, Radomir Jasiński   +3 more
doaj   +1 more source

Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease

Redox Biology, 2023
Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and mortality rates worldwide. Despite being monogenic, SCD patients display a plethora of disease-associated complications including anemia, oxidative stress, sterile ...
Fabliha A. Chowdhury, Nicole Colussi, Malini Sharma, Katherine C. Wood, Julia Z. Xu, Bruce A. Freeman, Francisco J. Schopfer, Adam C. Straub   +7 more
doaj   +1 more source

Nitroalkenes in the synthesis of carbocyclic compounds

, 2014
The applications of nitroalkenes in the synthesis of small, common and medium ring carbocycles, including natural products are investigated in this review.
Halimehjani, Azim Ziyaei, Hooshmand, Seyyed Emad, Namboothiri, Irishi N. N.   +2 more
core   +1 more source

Synthesis and anticancer activity studies of alpha-aminoalkylated conjugated nitroalkenes

, 2006
Novel alpha-aminoalkylated conjugated nitroalkenes which inhibit human cervical cancer (HeLa) cell proliferation by binding to tubulin were synthesized by imidazole/LiCl-mediated reaction of conjugated nitroalkenes with N-tosylimines.© The Royal Society ...
SHAIKH, MOBIN M, RASTOGI, NAMRATA, MOHAN, RENU, NAMBOOTHIRI, IRISHI NN, PANDA, DULAL   +4 more
core   +2 more sources

Synthesis of non-racemic 4-nitro-2-sulfonylbutan-1-ones via Ni(II)-catalyzed asymmetric Michael reaction of β-ketosulfones

Beilstein Journal of Organic Chemistry, 2019
Functionally substituted sulfones with stereogenic centers are valuable reagents in organic synthesis and key motifs in some bioactive compounds. The asymmetric Michael addition of β-ketosulfones to conjugated nitroalkenes in the presence of Ni(II ...
Alexander N. Reznikov, Anastasiya E. Sibiryakova, Marat R. Baimuratov, Eugene V. Golovin, Victor B. Rybakov, Yuri N. Klimochkin   +5 more
doaj   +1 more source

Preparation of conjugated nitroalkenes: short review [PDF]

, 2022
Key protocols of the preparation of conjugated nitroalkenes were reviewed and critically discussed. It was established, that optimal strategy for the obtaining of target compounds are small molecules extrusion processes from saturated nitro-compounds ...
Zawadzińska, Karolina, Gaurav, Gajendra Kumar, Jasiński, Radomir   +2 more
core   +1 more source

Substrate Walking for Selective Ene Reduction

ChemCatChem, Volume 18, Issue 9, 14 May 2026.
Ene‐reductases (EREDs) efficiently reduce activated C═C bonds. Expanding the current application, they catalyze the selective reduction of highly substituted cyclohexenones. Immobilized, they were scaled to 200 mL, achieving full substrate conversion without enzyme degradation. ABSTRACT Ene‐reductases (EREDs) efficiently reduce activated C═C bonds, but
Hugo Brasselet, Jonathan Berger, Elisa Arends, Adriaan de Man, Laura van der Weel, Hessel van Dijk, Anke Hummel, Harald Gröger, Ulf Hanefeld   +8 more
wiley   +1 more source

Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles

Frontiers in Chemistry, 2019
We report a metal-free and stereoselective four-component reaction between α-ketoamides, amines, aromatic aldehydes and β-nitroalkenes or β-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position.
Dong Wang, Xinyue Ma, Linru Dong, Hairong Feng, Peng Yu, Laurent Désaubry, Laurent Désaubry   +6 more
doaj   +1 more source