Results 61 to 70 of about 3,335 (198)
The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors
Protein Science, Volume 35, Issue 7, July 2026.Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley +1 more source
Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles
Frontiers in Chemistry, 2019 We report a metal-free and stereoselective four-component reaction between α-ketoamides, amines, aromatic aldehydes and β-nitroalkenes or β-pivaloxy-nitroalkanes to obtain 2,3-dihydro-4-nitropyrroles functionalized in every position.
Dong Wang +6 more
doaj +1 more source
Fast Reduction of Nitroalkenes Into Nitroalkanes Under Continuous‐Flow Chemical Conditions
European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.Flow chemical synthesis was employed for the reduction of nitroalkenes to the corresponding nitroalkanes using sodium borohydride as the reducing agent. The reaction proceeds in only 150 s, affording products from good‐to‐excellent yields (61–96%). Herein, we describe an efficient and rapid continuous‐flow reduction of nitroalkenes to nitroalkanes. The
Iqra Munir +3 more
wiley +1 more source
, 2006 Novel alpha-hydrazino-alpha,beta-unsaturated nitroalkenes, which exhibit dynamic phenomenon on the NMR time scale,were synthesized in excellent yields via imidazole or DMAP mediated Morita–Baylis–Hillman (MBH) type reaction of nitroalkenes with ...
SHAIKH, MOBIN M +4 more
core +1 more source
Acetaldehyde in the Enders triple cascade reaction via acetaldehyde dimethyl acetal
Beilstein Journal of Organic Chemistry, 2023 Asymmetric organocatalyzed multicomponent reactions represent an important toolbox in the field of organic synthesis to build complex scaffolds starting from simple starting materials.
Alessandro Brusa +7 more
doaj +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.This work describes the synthesis of lactose‐ and glucose‐derived chiral ligands and their application in the catalytic enantioselective Friedel–Crafts alkylation of indole with a series of trans‐β‐nitrostyrenes. The optimal ligand was an acetate protected, lactose‐derived pyridyl imine and its zinc complex afforded ees up to 93% and yields up to 93 ...
Sandra Bulawa +2 more
wiley +1 more source
, 2009 The first organocatalytic Mukaiyama-Michael addition of 2-trimethylsilyloxy furan to nitroalkenes was promoted by Brønsted acids under solvent-free conditions.
De Sio V. +8 more
core +1 more source
, 2016 Catalytic Asymmetric Intermolecular Stetter Reaction of Heterocyclic Aldehydes with Nitroalkenes: Backbone Fluorination Improves ...
Kevin M. Oberg (1685617) +3 more
core +4 more sources
European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.A cascade reaction under phase‐transfer conditions between 3‐nitro indoles and isocyanomethylene dibenzenes affords the construction of pyrrolo[3,4‐b]indole cores. Control experiments provide insight into moderate product yields and clarify why the reaction is not amenable to asymmetric induction. A cascade reaction enabling the construction of pyrrolo[
Ana Mikleušević +4 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2012 An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions.
Zong-Bo Xie +5 more
doaj +1 more source