Results 1 to 10 of about 2,944,243 (309)

Chiral amido-oxazoline functionalized MCM-41: A sustainable heterogeneous catalyst for enantioselective Kharasch–Sosnovsky and Henry reactions

Heliyon
In this study, a series of chiral amido-oxazoline ligands was synthesized with a primary focus on immobilizing the most effective ligands on MCM-41 mesoporous material.
Niloofar Tavakoli, Hamid Arvinnezhad, Shiva Majidian, Mahsa Mahramasrar, Khosrow Jadidi, Saadi Samadi   +5 more
doaj   +1 more source

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies

Molecules, 2023
Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD+ production ...
Paulina Biniecka, Saki Matsumoto, Axel Belotti, Jessie Joussot, Jian Fei Bai, Somi Reddy Majjigapu, Paul Thoueille, Dany Spaggiari, Vincent Desfontaine, Francesco Piacente, Santina Bruzzone, Michele Cea, Laurent A. Decosterd, Pierre Vogel, Alessio Nencioni, Michel A. Duchosal, Aimable Nahimana   +16 more
doaj   +1 more source

Synthesis and photophysical properties of new reactive fluorophenanthrenes

Comptes Rendus. Chimie, 2020
A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized through a simple procedure, making use of inexpensive starting materials under mild conditions.
Hajri, Amira K., Albalawi, Marzough A., Elsayed, Nadia H., Aloui, Faouzi   +3 more
doaj   +1 more source

Flow chemistry in the multi-step synthesis of natural products

Green Synthesis and Catalysis, 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the large environmental footprint. In the past two decades,
Li Wan, Gaopan Kong, Minjie Liu, Meifen Jiang, Dang Cheng, Fener Chen   +5 more
doaj   +1 more source

Asymmetric Total Synthesis of Nigerone [PDF]

Organic Letters, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Evan S, Divirgilio, Elizabeth C, Dugan, Carol A, Mulrooney, Marisa C, Kozlowski   +3 more
openaire   +2 more sources

Progress in Stereoselective Haloamination of Olefins

Molecules
The regio- and stereoselective adjacent bifunctionalization of olefins with amine and halogen groups can be effectively accomplished through catalytic haloamination methods.
Guo Zhong, Jiayu Zhou, Bin Cui, Hui Sun
doaj   +1 more source

A concise asymmetric synthesis of (−)-rasfonin [PDF]

Org. Biomol. Chem., 2012
A very efficient total synthesis of the apoptosis inducer (-)-rasfonin has been developed using CuBr/JosiPhos catalyzed iterative asymmetric conjugate addition of MeMgBr and Feringa's butenolide.
Huang, Yange, Minnaard, Adriaan J., Feringa, Ben L.   +2 more
openaire   +2 more sources

Recent advances in catalytic asymmetric synthesis [PDF]

Frontiers in Chemistry
Takahiko Akiyama
exaly   +2 more sources

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

Acta Pharmaceutica Sinica B, 2020
Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the cornerstone of HIV treatment.
Chunlin Zhuang, Christophe Pannecouque, Erik De Clercq, Fener Chen   +3 more
doaj   +1 more source

Chemical asymmetric synthesis

Nature, 1989
Thalidomide comes in two forms: a left-handed compound which is a powerful tranquilizer, and a right-handed version which can disrupt fetal development causing severe handicap. As a necessary consequence of synthetic methods available in the early 1960s the two forms were present in equal proportions in the manufactured drug, with catastrophic ...
Brown, J, Davies, S
openaire   +2 more sources