Results 41 to 50 of about 175,047 (318)
Molecules, 2023 Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD+ production ...
Paulina Biniecka +16 more
doaj +1 more source
Asymmetric synthesis via iron acyl complexes
, 1986 This thesis describes the applications to asymmetric synthesis of the highly diastereoselective carbon-carbon bond forming reactions of α,β-unsaturated acyl ligands bound to the chiral iron auxiliary [(η5-C5H5)Fe(CO)(PPh3)]. Chapter 1 briefly reviews the
Walker, Jonathan, Walker, J. C.
core +1 more source
Progress in Stereoselective Haloamination of Olefins
MoleculesThe regio- and stereoselective adjacent bifunctionalization of olefins with amine and halogen groups can be effectively accomplished through catalytic haloamination methods.
Guo Zhong, Jiayu Zhou, Bin Cui, Hui Sun
doaj +1 more source
Flow chemistry in the multi-step synthesis of natural products
Green Synthesis and Catalysis, 2022 The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the large environmental footprint. In the past two decades,
Li Wan +5 more
doaj +1 more source
Asymmetric synthesis of (−)-codonopsinine
Tetrahedron Letters, 2011 Abstract The asymmetric synthesis of (−)-codonopsinine was achieved in 7 steps (from commercially available tert-butyl crotonate) in 5% overall yield and >99:1 dr. The key step in this synthesis involved ring-closing iodoamination of a functionalised homoallylic amine, which occurred with concomitant N-debenzylation, to give a 3-iodopyrrolidine that ...
Davies, S +4 more
openaire +1 more source
Concise asymmetric synthesis of (−)-bilobalide [PDF]
Nature, 2019 The Ginkgo biloba metabolite bilobalide is widely ingested by humans but its effect on the mammalian central nervous system is not fully understood1-4. Antagonism of γ-aminobutyric acid A receptors (GABAARs) by bilobalide has been linked to the rescue of cognitive deficits in mouse models of Down syndrome5.
Baker, Meghan A. +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Asymmetric synthesis of enantioenriched spirocycles via a chiral Brønsted acid catalyzed desymmetrization [PDF]
, 2019 Asymmetric methodologies are very important as they allow chemists to produce significant quantities of complex chiral molecules as enantiopure or enantioenriched compounds.
Minerali, Eni +1 more
core
Synthesis and photophysical properties of new reactive fluorophenanthrenes
Comptes Rendus. Chimie, 2020 A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized through a simple procedure, making use of inexpensive starting materials under mild conditions.
Hajri, Amira K. +3 more
doaj +1 more source
Asymmetric Total Synthesis of Rollicosin. [PDF]
ChemInform, 2005 [structure: see text] The first total synthesis of rollicosin, a member of a rare subgroup of Annonaceous acetogenins containing two terminal gamma-lactones, is reported. The approach features a highly regio- and stereoselective tandem ring-closing/cross-metathesis reaction for construction of the east-wing lactone and incorporation of the alkyl spacer.
Kevin J, Quinn +4 more
openaire +2 more sources