Results 41 to 50 of about 426,599 (311)

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies

Molecules, 2023
Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD+ production ...
Paulina Biniecka, Saki Matsumoto, Axel Belotti, Jessie Joussot, Jian Fei Bai, Somi Reddy Majjigapu, Paul Thoueille, Dany Spaggiari, Vincent Desfontaine, Francesco Piacente, Santina Bruzzone, Michele Cea, Laurent A. Decosterd, Pierre Vogel, Alessio Nencioni, Michel A. Duchosal, Aimable Nahimana   +16 more
doaj   +1 more source

Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-Sphinganine, (+)-spisulosine and D-ribo-phytosphingosine [PDF]

, 2013
Two variations of the Overman rearrangement have been developed for the highly selective synthesis of anti-vicinal amino alcohol natural products. A MOM-ether directed palladium(II)-catalyzed rearrangement of an allylic trichloroacetimidate was used as ...
Abraham E., Ahmed M. Zaed, Ait-Youcef R., Allepuz A. C., Amarante G. W., Andrew Sutherland, Barrett A. G. M., Bernet B., Blanchette M. A., Cai Y., Cai Y., Chen B.-S., Cook G. R., Corey E. J., Corey E. J., Cuadros R., Davies S. G., Devi T. J., Dickson R. C., Dinda S. K., Enders D., Ewen D. D. Calder, Fanning K. N., Fernandes R. A., Ghosal P., Hertweck C., Hoffmann R. W., Howell A. R., Hubieki M. P., Jamieson A. G., Jamieson A. G., Jamieson A. G., Jamieson A. G., Kokatla H. P., Kolb H. C., Kolter T., Koskinen P. M., Lee S. I., Lipshutz B. H., Liu Z., Llaveria J., Lombardo M., Luo S.-Y., Malik G., Martinková M., Modrak D. E., Morales-Serna J. A., Murakami T., Naidu S. V., Ndakala A. J., Ndonye R. M., Perali R. S., Prabhakar P., Rodriguez-Lafrasse C., Schneiter R., Sengupta S., Snook C. F., So R. C., Summers S. A., Swift M. D., Séguin C., Watanabe M., Xarnod C., Xu K., Yoon H. J., Yun J. M., Zaed A., Zaed A. M.   +67 more
core   +1 more source

Progress in Stereoselective Haloamination of Olefins

Molecules
The regio- and stereoselective adjacent bifunctionalization of olefins with amine and halogen groups can be effectively accomplished through catalytic haloamination methods.
Guo Zhong, Jiayu Zhou, Bin Cui, Hui Sun
doaj   +1 more source

Flow chemistry in the multi-step synthesis of natural products

Green Synthesis and Catalysis, 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the large environmental footprint. In the past two decades,
Li Wan, Gaopan Kong, Minjie Liu, Meifen Jiang, Dang Cheng, Fener Chen   +5 more
doaj   +1 more source

Heterogenisation of ketone catalysts within mesoporous supports for asymmetric epoxidation

, 2013
The synthesis of the first mesoporous silica (150 Å) anchored carbohydrate-derived chiral ketone is described. This new heterogeneous catalyst has been shown to be effective in the asymmetric epoxidation of olefins by oxone.
Adam, Aggarwal, Amadori, Amadori, Armstrong, Beckwith, Bellamy, Bloch, Caprio, Chadwick, Cho, Corey, Denmark, Denmark, Denmark, Dondoni, Farina, Frohn, Goeddel, Heitbaum, Hutchings, Jacobsen, Johansson Seechurn, Johnson, Johnson, Jones, Katsuki, McMorn, Page, Page, Pedragosa-Moreau, Raja, Raynor, Ren, Romesberg, Ross, Sartori, Shephard, Shu, Song, Stearman, Thomas, Thomas, Thomas, Tian, Tian, Tian, van den Broek, Wang, Wang, Wang, Wang, Wong, Wong, Xia, Xiong, Xuereb, Yang, Yang, Zhao, Zhu   +60 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Synthesis and photophysical properties of new reactive fluorophenanthrenes

Comptes Rendus. Chimie, 2020
A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized through a simple procedure, making use of inexpensive starting materials under mild conditions.
Hajri, Amira K., Albalawi, Marzough A., Elsayed, Nadia H., Aloui, Faouzi   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Chiral amido-oxazoline functionalized MCM-41: A sustainable heterogeneous catalyst for enantioselective Kharasch–Sosnovsky and Henry reactions

Heliyon
In this study, a series of chiral amido-oxazoline ligands was synthesized with a primary focus on immobilizing the most effective ligands on MCM-41 mesoporous material.
Niloofar Tavakoli, Hamid Arvinnezhad, Shiva Majidian, Mahsa Mahramasrar, Khosrow Jadidi, Saadi Samadi   +5 more
doaj   +1 more source

Synthesis of enantioenriched sulfoxides [PDF]

, 2010
This review discusses strategies for the asymmetric synthesis of sulfoxides, compounds with many applications in stereoselective synthesis and in some cases with pharmaceutical application.
Kelly, Padraig, Lawrence, Simon E., Maguire, Anita R., O'Mahony, Graham E.   +3 more
core   +1 more source