Results 51 to 60 of about 426,599 (311)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

Acta Pharmaceutica Sinica B, 2020
Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the cornerstone of HIV treatment.
Chunlin Zhuang, Christophe Pannecouque, Erik De Clercq, Fener Chen   +3 more
doaj   +1 more source

Asymmetric Synthesis of Ageliferin [PDF]

Journal of the American Chemical Society, 2011
We describe herein an asymmetric synthesis of ageliferin. A Mn(III)-mediated oxidative radical cyclization reaction was used as the key step to construct the core skeleton of this pyrrole-imidazole dimer. This approach resembles the biogenic [4 + 2] dimerization in an intramolecular fashion.
Xiao, Wang, Zhiqiang, Ma, Jianming, Lu, Xianghui, Tan, Chuo, Chen   +4 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Molecular docking investigation of cytotoxic phenanthrene derivatives

Comptes Rendus. Chimie, 2020
Our previous experimental work indicated that the presence of ester functionality in phenanthrene derivatives D-1 and D-2 leads to potent cytotoxicity against the Caco-2 cell line. The present work is based on th-is experimental result.
Guédouar, Habiba, Zaki, Hanane, Bouachrine, Mohammed, Aloui, Faouzi   +3 more
doaj   +1 more source

Development of diverse adjustable axially chiral biphenyl ligands and catalysts

iScience, 2023
Summary: Development of highly efficient and practical chiral ligands and catalysts is an eternal theme in asymmetric synthesis. Here, we report the design, synthesis, and evaluation of a new kind of adjustable axially chiral biphenyl ligands and ...
Jiyang Jie, Haijun Yang, Yufen Zhao, Hua Fu   +3 more
doaj   +1 more source

Chiral polymerization: symmetry breaking and entropy production in closed systems

, 2011
We solve numerically a kinetic model of chiral polymerization in systems closed to matter and energy flow, paying special emphasis to its ability to amplify the small initial enantiomeric excesses due to the internal and unavoidable statistical ...
Avetisov, Avetisov, Blanco, Blocher, Brandenburg, Brandenburg, Brandenburg, Celia Blanco, Chaikin, Cross, Crusats, David Hochberg, De Greef, Frank, Gleiser, Gleiser, Gleiser, Gleiser, Goldanski, Guijarro, Hitz, Hitz, Hochberg, Illos, Kondepudi, Kondepudi, Kondepudi, Mauksch, Mills, Mislow, Nery, Plasson, Ribó, Ross, Rubinstein, Rubinstein, Saito, Sandars, Scott, Siegel, Stier, Stier, Wattis, Wattis, Weissbuch, Weissbuch   +45 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review

Molecules, 2023
Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand.
Aqsa Mushtaq, Ameer Fawad Zahoor, Muhammad Bilal, Syed Makhdoom Hussain, Muhammad Irfan, Rabia Akhtar, Ali Irfan, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +8 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source