Results 51 to 60 of about 3,123,489 (311)

Asymmetric Synthesis of Maraviroc (UK-427,857)

, 2010
The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral beta-amino aldehyde key fragment is presented.
Martin Kullberg, Korotvicka, Ales, Aleš Korotvička, Kullberg, Martin,, Zhao, Gui-Ling, Lin, Shuangzheng, Kullberg, Martin, Gui-Ling Zhao, Korotvicka, Ales,, Deiana, Luca,, Luca Deiana, Deiana, Luca, Armando Córdova, Zhao, Gui-Ling,, Cordova, Armando,, Shuangzheng Lin, Lin, Shuangzheng,   +16 more
core   +1 more source

A Single-Step Asymmetric Phosphodiester Synthesis from Alcohols with Phosphoenolpyruvate Phosphodiester [PDF]

, 2021
Phosphodiester are important structural motifs observed in a diverse field of molecular science. It is, thus, important to develop a simple and robust way to synthesize them from corresponding alcohols.
Shigehiro, Kawashima, Kohei, Fujiyoshi, Motomu, Kanai, Kenzo, Yamatsugu   +3 more
core   +1 more source

Chiral Betti base immobilized on UiO-66-NH

Heliyon
Newly developed chiral heterogeneous ligands were prepared by immobilizing chiral ( R )-(−)- and ( S )-(+)-Betti bases onto functionalized UiO-66-NH 2 .
Saadi Samadi, Bahareh Rostami Tabesh, Hamid Arvinnezhad   +2 more
doaj   +1 more source

Synthesis and photophysical properties of new reactive fluorophenanthrenes

Comptes Rendus. Chimie, 2020
A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized through a simple procedure, making use of inexpensive starting materials under mild conditions.
Hajri, Amira K., Albalawi, Marzough A., Elsayed, Nadia H., Aloui, Faouzi   +3 more
doaj   +1 more source

Flow chemistry in the multi-step synthesis of natural products

Green Synthesis and Catalysis, 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the large environmental footprint. In the past two decades,
Li Wan, Gaopan Kong, Minjie Liu, Meifen Jiang, Dang Cheng, Fener Chen   +5 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Chemical asymmetric synthesis

Nature, 1989
Thalidomide comes in two forms: a left-handed compound which is a powerful tranquilizer, and a right-handed version which can disrupt fetal development causing severe handicap. As a necessary consequence of synthetic methods available in the early 1960s the two forms were present in equal proportions in the manufactured drug, with catastrophic ...
Brown, J, Davies, S
openaire   +2 more sources

Asymmetric Synthesis of the Tetraponerine Alkaloids [PDF]

The Journal of Organic Chemistry, 2017
The asymmetric syntheses of all eight tetraponerine alkaloids (T1-T8) were achieved using the diastereoselective conjugate additions of lithium amide reagents in the key stereodefining steps. Conjugate addition of either lithium (R)-N-allyl-N-(α-methylbenzyl)amide or lithium (R)-N-(but-3-en-1-yl)-N-(α-methylbenzyl)amide to tert-butyl sorbate was ...
Stephen G. Davies, Ai M. Fletcher, Ian T. T. Houlsby, Paul M. Roberts, James E. Thomson   +4 more
openaire   +2 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Asymmetric synthesis of (−)-codonopsinine

Tetrahedron Letters, 2011
Abstract The asymmetric synthesis of (−)-codonopsinine was achieved in 7 steps (from commercially available tert-butyl crotonate) in 5% overall yield and >99:1 dr. The key step in this synthesis involved ring-closing iodoamination of a functionalised homoallylic amine, which occurred with concomitant N-debenzylation, to give a 3-iodopyrrolidine that ...
Davies, S, Lee, J, Roberts, P, Thomson, J, West, C   +4 more
openaire   +1 more source