Results 71 to 80 of about 175,047 (318)
Recent trends and developments in the asymmetric synthesis of profens
Green Synthesis and Catalysis, 2023 The profens belong to a class of nonsteroidal anti-inflammatory drugs (NSAIDs), which exert significant anti-inflammatory, analgesic, antipyretic and other pharmacological effects.
Qiuyue Wang +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 2021 Phosphodiester are important structural motifs observed in a diverse field of molecular science. It is, thus, important to develop a simple and robust way to synthesize them from corresponding alcohols.
Shigehiro, Kawashima +3 more
core +1 more source
Scientific AfricanIn this study, we designed and evaluated high-efficiency coumarin-based small-molecule donors for organic solar cells (OSCs) using density functional theory (DFT) calculations to address the challenge of improving charge transfer and photovoltaic ...
Walid Taouali +2 more
doaj +1 more source
Targeting human MutT homolog 1 (MTH1) for cancer eradication: current progress and perspectives
Acta Pharmaceutica Sinica B, 2020 Since accelerated metabolism produces much higher levels of reactive oxygen species (ROS) in cancer cells compared to ROS levels found in normal cells, human MutT homolog 1 (MTH1), which sanitizes oxidized nucleotide pools, was recently demonstrated to ...
Yizhen Yin, Fener Chen
doaj +1 more source
Chiral Hydroxamic Acid Ligands in the Asymmetric Synthesis of Natural Products
Chemistry, 2023 Chiral hydroxamic acid (HA) and bis-hydroxamic acid (BHA) ligands have made significant contributions to the field of asymmetric synthesis, particularly in the synthesis of natural products.
Tushar Janardan Pawar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2011 Synthesis of Electronically Deficient Atropisomeric Bisphosphine Ligands and Their Application in Asymmetric Hydrogenation of QuinolinesA series of electronically deficient atropisomeric bisphosphine ligands have been synthesized from (S)-MeO-BiPhep. The
王敏灿 +7 more
core +1 more source
Nature CommunicationsAsymmetric catalysis for enantioselective intramolecular hydroamination of alkenes is a critical method in the construction of enantioenriched nitrogen-containing rings, often prevalent in biologically active compounds and natural products.
Bin Cui +6 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source