Results 71 to 80 of about 2,944,243 (309)
Molecules, 2023 Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand.
Aqsa Mushtaq +8 more
doaj +1 more source
Concise asymmetric synthesis of (−)-bilobalide [PDF]
Nature, 2019 The Ginkgo biloba metabolite bilobalide is widely ingested by humans but its effect on the mammalian central nervous system is not fully understood1-4. Antagonism of γ-aminobutyric acid A receptors (GABAARs) by bilobalide has been linked to the rescue of cognitive deficits in mouse models of Down syndrome5.
Baker, Meghan A. +3 more
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Aggregation-Induced Synthesis (AIS): Asymmetric Synthesis via Chiral Aggregates
Research, 2022 A new chiral aggregate-based tool for asymmetric synthesis has been developed by taking advantage of chiral aggregates of GAP (Group-Assisted Purification) reagents, N-phosphonyl imines.
Hossein Rouh +11 more
doaj +1 more source
Asymmetric Total Synthesis of Rollicosin. [PDF]
ChemInform, 2005 [structure: see text] The first total synthesis of rollicosin, a member of a rare subgroup of Annonaceous acetogenins containing two terminal gamma-lactones, is reported. The approach features a highly regio- and stereoselective tandem ring-closing/cross-metathesis reaction for construction of the east-wing lactone and incorporation of the alkyl spacer.
Kevin J, Quinn +4 more
openaire +2 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Scientific AfricanIn this study, we designed and evaluated high-efficiency coumarin-based small-molecule donors for organic solar cells (OSCs) using density functional theory (DFT) calculations to address the challenge of improving charge transfer and photovoltaic ...
Walid Taouali +2 more
doaj +1 more source
Targeting human MutT homolog 1 (MTH1) for cancer eradication: current progress and perspectives
Acta Pharmaceutica Sinica B, 2020 Since accelerated metabolism produces much higher levels of reactive oxygen species (ROS) in cancer cells compared to ROS levels found in normal cells, human MutT homolog 1 (MTH1), which sanitizes oxidized nucleotide pools, was recently demonstrated to ...
Yizhen Yin, Fener Chen
doaj +1 more source
Peptides as catalysts for asymmetric 1,4-addition reactions of aldehydes to nitroolefins [PDF]
, 2009 Within this thesis, the development of peptides as highly efficient catalysts for asymmetric conjugate addition reactions of aldehydes to nitroolefins is described.
Wiesner, Markus
core +1 more source