Results 81 to 90 of about 175,047 (318)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Asymmetric Synthesis of Maraviroc (UK-427,857)

, 2010
The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral beta-amino aldehyde key fragment is presented.
Martin Kullberg, Korotvicka, Ales, Aleš Korotvička, Kullberg, Martin,, Zhao, Gui-Ling, Lin, Shuangzheng, Kullberg, Martin, Gui-Ling Zhao, Korotvicka, Ales,, Deiana, Luca,, Luca Deiana, Deiana, Luca, Armando Córdova, Zhao, Gui-Ling,, Cordova, Armando,, Shuangzheng Lin, Lin, Shuangzheng,   +16 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Enantioselective acyl-trifluoromethylation of olefins by bulky thiazolium carbene catalysis

Nature Communications
Enantioenriched α-chiral β-fluorinated ketones are valuable structural motifs with application in several fields. The recently emerged concept of NHC-catalyzed radical acyl-trifluoromethylation of olefins offers a rapid route to construct racemic β ...
Sripati Jana, Matthew D. Wodrich, Nicolai Cramer   +2 more
doaj   +1 more source

Crystal structure of 2-(8-bromo-2-phenylimidazo[1,2-α]pyridin-3-yl)-6,7-dimethyl-3-phenylquinoxaline, C29H21BrN4

Zeitschrift für Kristallographie - New Crystal Structures, 2018
C29H21BrN4, orthorhombic, Pca21 (no. 29), a = 15.6577(5) Å, b = 9.6445(3) Å, c = 31.1869(10) Å, V = 4709.6(2) Å3, Z = 8, Rgt(F) = 0.0435, wRref(F2) = 0.0779, T = 293(2) K.
Song Gui Ting, Meng Jiang Ping, Zhu Jin
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Synthesis of pyran and related natural products [PDF]

, 2012
This study was aimed at preparing dihydropyrans (DHPs) for the synthesis of 2,6-disubstituted tetrahydropyrans (THPs) in a diastereoselective manner. In an attempt to develop a novel methodology for the synthesis of DHPs from δ-hydroxy-β-ketoester and ...
Yeung, Bun
core  

Asymmetric synthesis of the Martinella alkaloids

, 2013
This thesis is concerned with the application of the conjugate addition of enantiopure lithium amides in the asymmetric syntheses of (−)-martinellic acid.
Davies, Stephen G, Lorkin, Thomas J A, Lorkin, Thomas James Anthony   +2 more
core   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Asymmetric Total Synthesis of Arcutinidine and Arcutinine

, 2019
We have accomplished the asymmetric total synthesis of arcutinidine and arcutinine, two arcutine-type C20-diterpenoid alkaloids. A pentacyclic intermediate was rapidly assembled by using two Diels−Alder reactions.
Ang, Li, Ang Li (6752492), Shupeng, Zhou, Kaifu, Xia, Shupeng Zhou (6752495), Kaifu Xia (6739085)   +5 more
core   +1 more source