Results 61 to 70 of about 3,123,489 (311)
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
A versatile messenger for chirality communication: asymmetric silica framework
, 2021 Asymmetric tetrahedral carbon is the basic structural unit of many organic compounds in life and its molecular chirality plays a key role in regulating biological functions.
Liu, Xinling, Jin, Ren-Hua
core
Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years
Acta Pharmaceutica Sinica B, 2020 Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the cornerstone of HIV treatment.
Chunlin Zhuang +3 more
doaj +1 more source
Concise asymmetric synthesis of (−)-bilobalide [PDF]
Nature, 2019 The Ginkgo biloba metabolite bilobalide is widely ingested by humans but its effect on the mammalian central nervous system is not fully understood1-4. Antagonism of γ-aminobutyric acid A receptors (GABAARs) by bilobalide has been linked to the rescue of cognitive deficits in mouse models of Down syndrome5.
Baker, Meghan A. +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Asymmetric Synthesis of (+)-Deoxoprosopinine
, 2016 Asymmetric Synthesis of ...
Daniel L. Comins (222088) +2 more
core +1 more source
Molecular docking investigation of cytotoxic phenanthrene derivatives
Comptes Rendus. Chimie, 2020 Our previous experimental work indicated that the presence of ester functionality in phenanthrene derivatives D-1 and D-2 leads to potent cytotoxicity against the Caco-2 cell line. The present work is based on th-is experimental result.
Guédouar, Habiba +3 more
doaj +1 more source
Development of diverse adjustable axially chiral biphenyl ligands and catalysts
iScience, 2023 Summary: Development of highly efficient and practical chiral ligands and catalysts is an eternal theme in asymmetric synthesis. Here, we report the design, synthesis, and evaluation of a new kind of adjustable axially chiral biphenyl ligands and ...
Jiyang Jie +3 more
doaj +1 more source
Asymmetric Total Synthesis of Rollicosin. [PDF]
ChemInform, 2005 [structure: see text] The first total synthesis of rollicosin, a member of a rare subgroup of Annonaceous acetogenins containing two terminal gamma-lactones, is reported. The approach features a highly regio- and stereoselective tandem ring-closing/cross-metathesis reaction for construction of the east-wing lactone and incorporation of the alkyl spacer.
Kevin J, Quinn +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source