Results 61 to 70 of about 2,944,243 (309)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Asymmetric synthesis of the Martinella alkaloids [PDF]
, 2013 This thesis is concerned with the application of the conjugate addition of enantiopure lithium amides in the asymmetric syntheses of (−)-martinellic acid.
Davies, Stephen G +2 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Asymmetric Synthesis of the Tetraponerine Alkaloids [PDF]
The Journal of Organic Chemistry, 2017 The asymmetric syntheses of all eight tetraponerine alkaloids (T1-T8) were achieved using the diastereoselective conjugate additions of lithium amide reagents in the key stereodefining steps. Conjugate addition of either lithium (R)-N-allyl-N-(α-methylbenzyl)amide or lithium (R)-N-(but-3-en-1-yl)-N-(α-methylbenzyl)amide to tert-butyl sorbate was ...
Stephen G. Davies +4 more
openaire +2 more sources
Molecular docking investigation of cytotoxic phenanthrene derivatives
Comptes Rendus. Chimie, 2020 Our previous experimental work indicated that the presence of ester functionality in phenanthrene derivatives D-1 and D-2 leads to potent cytotoxicity against the Caco-2 cell line. The present work is based on th-is experimental result.
Guédouar, Habiba +3 more
doaj +1 more source
Development of diverse adjustable axially chiral biphenyl ligands and catalysts
iScience, 2023 Summary: Development of highly efficient and practical chiral ligands and catalysts is an eternal theme in asymmetric synthesis. Here, we report the design, synthesis, and evaluation of a new kind of adjustable axially chiral biphenyl ligands and ...
Jiyang Jie +3 more
doaj +1 more source
Asymmetric synthesis of (−)-codonopsinine
Tetrahedron Letters, 2011 Abstract The asymmetric synthesis of (−)-codonopsinine was achieved in 7 steps (from commercially available tert-butyl crotonate) in 5% overall yield and >99:1 dr. The key step in this synthesis involved ring-closing iodoamination of a functionalised homoallylic amine, which occurred with concomitant N-debenzylation, to give a 3-iodopyrrolidine that ...
Davies, S +4 more
openaire +1 more source
Asymmetric Total Synthesis of Arcutinidine and Arcutinine [PDF]
, 2019 We have accomplished the asymmetric total synthesis of arcutinidine and arcutinine, two arcutine-type C20-diterpenoid alkaloids. A pentacyclic intermediate was rapidly assembled by using two Diels−Alder reactions.
Ang, Li +5 more
core +2 more sources
Rhodium catalysed asymmetric synthesis of tertiary amines [PDF]
, 2020 The asymmetric synthesis of tertiary amines is a highly desirable goal, but far fewer efficient synthetic methods exist for their synthesis, relative to primary and secondary amines.
Gilbert, Sophie Hannah
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source