Results 31 to 40 of about 426,599 (311)

Asymmetric synthesis of gonytolide A: strategic use of an aryl halide blocking group for oxidative coupling [PDF]

, 2018
The first synthesis of the chromanone lactone dimer gonytolide A has been achieved employing vanadium(V)-mediated oxidative coupling of the monomer gonytolide C. An o-bromine blocking group strategy was employed to favor para- para coupling and to enable
Iwata, Takayuki, Porco, John A., Qin, Tian, Reichl, Kyle D., Scharf, Adam, Wu, Xiaowei   +5 more
core   +1 more source

Stereoselective synthesis of hydroxylated 3-aminoazepanes using a multi-bond forming, three-step tandem process [PDF]

, 2012
A multi-bond forming, three-step tandem process involving a palladium(II)-catalysed Overman rearrangement and a ring closing metathesis reaction has been utilised for the efficient synthesis of a 2,3,6,7-tetrahydro-3-amidoazepine.
Ahmad, Ahmad, Anderson, Anderson, Anderson, Andrew Sutherland, Bernstein, Blades, Blanchette, Cant, Cardillo, Chapman, Cini, Cook, Cutri, Cutri, Delmore, Donohoe, Donohoe, Donohoe, Elhalem, Fürstner, Gilmet, Henbest, Horbal, Ireland, Jobson, Jobson, Kantorowski, Kazi, Kulanthaivel, Kurihara, Lampe, Louvel, Maier, Masse, McGonagle, Miyabe, Miyabe, Moriwake, Nicolaou, Nomura, O'Brien, Overman, Pimlott, Riber, Sajjad Ahmad, Sanford, Scholl, Schwab, Schwab, Srivastava, Stevens, Swift, Swift, Tietze, Trost, Valle, Watson, Würdemann, Yar, Yaragorla, Yet, Zaed   +63 more
core   +1 more source

Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Acta Pharmaceutica Sinica B, 2020
In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines (NP-DATAs), synthesis of a series of novel biphenyl-substituted diaryltriazines (BP-DATAs) with a flexible side chain attached at the C-6 position is ...
Kaijun Jin, Minjie Liu, Chunlin Zhuang, Erik De Clercq, Christophe Pannecouque, Ge Meng, Fener Chen   +6 more
doaj   +1 more source

Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols

iScience, 2018
Summary: Chiral syn-1,3-diols are fundamental structural motifs in many natural products and drugs. The traditional Narasaka-Prasad diastereoselective reduction from chiral β-hydroxyketones is an important process for the synthesis of these ...
Guanxin Huang, Minjie Liu, Fangjun Xiong, Ge Meng, Yuan Tao, Yan Wu, Haihui Peng, Fener Chen   +7 more
doaj   +1 more source

Synthesis and Applications of Asymmetric Catalysis Using Chiral Ligands Containing Quinoline Motifs

SynOpen, 2022
In the past decade, asymmetric synthesis of chiral ligands containing quinoline motifs, a family of natural products displaying a broad range of structural diversity and their metal complexes, have become the most significant methodology for the ...
Vasudevan Dhayalan, Rambabu Dandela, K. Bavya Devi, Ragupathy Dhanusuraman   +3 more
doaj   +1 more source

Asymmetric oxidation of sulfides [PDF]

, 2016
This review discusses synthesis of enantiopure sulfoxides through the asymmetric oxidation of prochiral sulfides. The use of metal complexes to promote asymmetric sulfoxidation is described in detail, with a particular emphasis on the synthesis of ...
Ford, Alan, Maguire, Anita R., O'Mahony, Graham E.   +2 more
core   +1 more source

Making Asymmetric Dark Matter Gold: Early Universe Synthesis of Nuggets [PDF]

, 2017
We compute the mass function of bound states of Asymmetric Dark Matter--nuggets--synthesized in the early Universe. We apply our results for the nugget density and binding energy computed from a nuclear model to obtain analytic estimates of the typical ...
Gresham, Moira I., Lou, Hou Keong, Zurek, Kathryn M.   +2 more
core   +3 more sources

Computational and Experimental Studies on the α-Functionalization of Ketones Using Domino Reactions: A Strategy to Increase Chemoselectivity at the α-Carbon of Ketones

Molecules
A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in the α-functionalization of ketones.
Hui Sun, Li-Heng Yang, Meng-Yun Fu, Bin Cui   +3 more
doaj   +1 more source

Therapeutic Effects of Coumarins with Different Substitution Patterns

Molecules, 2023
The use of derivatives of natural and synthetic origin has gained attention because of their therapeutic effects against human diseases. Coumarins are one of the most common organic molecules and are used in medicine for their pharmacological and ...
Virginia Flores-Morales, Ana P. Villasana-Ruíz, Idalia Garza-Veloz, Samantha González-Delgado, Margarita L. Martinez-Fierro   +4 more
doaj   +1 more source

MCM-41-supported L-phenylalaninol as a chiral heterogeneous ligand in the enantioselective Kharasch-Sosnovsky reaction

Results in Chemistry
In this study, L-phenylalaninol, synthesized from the reduction of naturally occurring L-phenylalanine, was immobilized on MCM-41. The resulting heterogeneous ligand was comprehensively characterized using various spectroscopic techniques, such as FT-IR,
Saadi Samadi, Shadi Kamangar, Hamid Arvinnezhad, Parya Noori   +3 more
doaj   +1 more source