Results 11 to 20 of about 426,599 (311)
Nature, 1989 Thalidomide comes in two forms: a left-handed compound which is a powerful tranquilizer, and a right-handed version which can disrupt fetal development causing severe handicap. As a necessary consequence of synthetic methods available in the early 1960s the two forms were present in equal proportions in the manufactured drug, with catastrophic ...
Brown, J, Davies, S
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Comptes Rendus. Chimie, 2021 7-Cyano-15-methoxy[6]helicene was synthesized, in 54% overall yield, through a short photochemical procedure including mild conditions and inexpensive reagents.
Hafedh, Nesrine +2 more
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Synthesis method of asymmetric gold particles. [PDF]
, 2017 Asymmetric particles can exhibit unique properties. However, reported synthesis methods for asymmetric particles hinder their application because these methods have a limited scale and lack the ability to afford particles of varied shapes.
Hahm, Eunil +3 more
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Beilstein Journal of Organic Chemistry, 2021 A facile synthesis of 2,4-diaryl-9-chloro-5,6,7,8-tetrahydroacridine derivatives is reported which is based on POCl3-mediated cyclodehydration followed by double Suzuki–Miyaura cross-coupling.
Najeh Tka +4 more
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Asymmetric Hydrogenation in Water by a Rhodium Complex of Sulfonated 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (binap) [PDF]
, 1993 The synthesis of sulfonated 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (binap) is reported; a rhodium complex of this ligand is the first to perform asymmetric hydrogenation in neat water with optical yields as high as those obtained in nonaqueous ...
Davis, Mark E., Wan, Kam-to
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2,4-Bis(arylethynyl)-9-chloro-5,6,7,8-tetrahydroacridines: synthesis and photophysical properties
Beilstein Journal of Organic Chemistry, 2021 Acridine derivatives have attracted considerable interest in numerous areas owing to their attractive physical and chemical properties. Herein, starting from readily available anthranilic acid, an efficient synthesis of 2,4-bis(arylethynyl)-9-chloro-5,6 ...
Najeh Tka +7 more
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Asymmetric synthesis of (−)-naltrexone
Chemical Science, 2019 The asymmetric synthesis of (−)-naltrexone was achieved by a Rh(i)-catalyzed C–H alkenylation and torquoselective electrocyclization cascade and late-stage C–H hydroxylation.
Sun Dongbang +2 more
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In Vivo Nanodetoxication for Acute Uranium Exposure
Molecules, 2015 Accidental exposure to uranium is a matter of concern, as U(VI) is nephrotoxic in both human and animal models, and its toxicity is associated to chemical toxicity instead of radioactivity. We synthesized different PAMAM G4 and G5 derivatives in order to
Luis Guzmán +4 more
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Continuous-Flow Synthesis of the Nucleobase Unit of Remdesivir
Engineering, 2023 In this work, the nucleobase unit of the antiviral drug remdesivir, 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, was synthesized through five-step continuous flow.
Yongxing Guo +5 more
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Synthesis of Solution-Phase Phosphoramidite and Phosphite Ligand Libraries and Their In Situ Screening in the Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids [PDF]
, 2007 Herein, we report the automated parallel synthesis of solution-phase libraries of phosphoramidite ligands for the development of enantioselective catalysts.
Feringa, Ben L., +5 more
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