Results 11 to 20 of about 175,047 (318)
Asymmetric synthesis of (−)-naltrexone
Chemical Science, 2019 The asymmetric synthesis of (−)-naltrexone was achieved by a Rh(i)-catalyzed C–H alkenylation and torquoselective electrocyclization cascade and late-stage C–H hydroxylation.
Sun Dongbang +2 more
openaire +3 more sources
Beilstein Journal of Organic Chemistry, 2021 A facile synthesis of 2,4-diaryl-9-chloro-5,6,7,8-tetrahydroacridine derivatives is reported which is based on POCl3-mediated cyclodehydration followed by double Suzuki–Miyaura cross-coupling.
Najeh Tka +4 more
doaj +1 more source
Asymmetric synthesis of nortropanes via Rh-catalysed allylic arylation
, 2022 Tropane derivatives are extensively used in medicine, but catalytic asymmetric methods for their synthesis are underexplored. Here we report Rh-catalysed asymmetric Suzuki-Miyaura type cross coupling reactions between a racemic N-Boc-nortropane-derived ...
Stephen P., Fletcher +3 more
core +1 more source
2,4-Bis(arylethynyl)-9-chloro-5,6,7,8-tetrahydroacridines: synthesis and photophysical properties
Beilstein Journal of Organic Chemistry, 2021 Acridine derivatives have attracted considerable interest in numerous areas owing to their attractive physical and chemical properties. Herein, starting from readily available anthranilic acid, an efficient synthesis of 2,4-bis(arylethynyl)-9-chloro-5,6 ...
Najeh Tka +7 more
doaj +1 more source
In Vivo Nanodetoxication for Acute Uranium Exposure
Molecules, 2015 Accidental exposure to uranium is a matter of concern, as U(VI) is nephrotoxic in both human and animal models, and its toxicity is associated to chemical toxicity instead of radioactivity. We synthesized different PAMAM G4 and G5 derivatives in order to
Luis Guzmán +4 more
doaj +1 more source
Continuous-Flow Synthesis of the Nucleobase Unit of Remdesivir
Engineering, 2023 In this work, the nucleobase unit of the antiviral drug remdesivir, 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, was synthesized through five-step continuous flow.
Yongxing Guo +5 more
doaj +1 more source
Transition metal-catalyzed branch-selective hydroformylation of olefins in organic synthesis
Green Synthesis and Catalysis, 2021 Hydroformylation of olefins can generate linear and branched aldehydes, and the branched aldehydes are attractive precursors for the synthesis of fine chemicals and pharmaceuticals.
Yingtang Ning +2 more
doaj +1 more source
Molecules, 2015 Volatile phenols, such as 4-ethyphenol (4-EP) and 4-ethylguaiacol (4-EG), are responsible for the “Brett character” found in wines contaminated with Brettanomyces yeast (i.e., barnyard, animal, spicy and smoky aromas).
Verónica Carrasco-Sánchez +4 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2023 Our recent studies for nonnucleoside reverse transcriptase inhibitors identified a highly potent compound JK-4b against WT HIV-1 (EC50 = 1.0 nmol/L), but the poor metabolic stability in human liver microsomes (t1/2 = 14.6 min) and insufficient ...
Xin Jin +9 more
doaj +1 more source