Results 21 to 30 of about 3,123,489 (311)

Continuous-Flow Synthesis of the Nucleobase Unit of Remdesivir

Engineering, 2023
In this work, the nucleobase unit of the antiviral drug remdesivir, 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, was synthesized through five-step continuous flow.
Yongxing Guo, Minjie Liu, Meifen Jiang, Yuan Tao, Dang Cheng, Fen-Er Chen   +5 more
doaj   +1 more source

Transition metal-catalyzed branch-selective hydroformylation of olefins in organic synthesis

Green Synthesis and Catalysis, 2021
Hydroformylation of olefins can generate linear and branched aldehydes, and the branched aldehydes are attractive precursors for the synthesis of fine chemicals and pharmaceuticals.
Yingtang Ning, Tomohiko Ohwada, Fen-Er Chen   +2 more
doaj   +1 more source

Asymmetric synthesis of tri- and tetrasubstituted trifluoromethyl dihydropyranones from alpha-aroyloxyaldehydes via NHC redox catalysis [PDF]

, 2014
We thank the Royal Society for a University Research Fellowship (A.D.S.), and the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement No.
Smith, Andrew D., Philip M. Pickett, Philip M. Pickett (1771471), Alexandra M. Z. Slawin (809268), Alyn T. Davies (1771468), Andrew D. Smith, Davies, Alyn T., Pickett, Philip M., Alexandra M. Z. Slawin, Slawin, Alexandra M. Z., Alyn T. Davies, Andrew D. Smith (494170), Smith, Andrew D.; id_orcid, Slawin, Alexandra M. Z.; id_orcid   +13 more
core   +1 more source

Removal of 4-Ethylphenol and 4-Ethylguaiacol with Polyaniline-Based Compounds in Wine-Like Model Solutions and Red Wine

Molecules, 2015
Volatile phenols, such as 4-ethyphenol (4-EP) and 4-ethylguaiacol (4-EG), are responsible for the “Brett character” found in wines contaminated with Brettanomyces yeast (i.e., barnyard, animal, spicy and smoky aromas).
Verónica Carrasco-Sánchez, Amalraj John, Adolfo Marican, Leonardo S. Santos, V. Felipe Laurie   +4 more
doaj   +1 more source

Erratum: Carrasco-Sánchez, V.; et al. Removal of 4-Ethylphenol and 4-Ethylguaiacol with Polyaniline-Based Compounds in Wine-Like Model Solutions and Red Wine. Molecules 2015, 20(8), 14312–14325

Molecules, 2017
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Verónica Carrasco-Sánchez, Amalraj John, Adolfo Marican, Leonardo S. Santos, V. Felipe Laurie   +4 more
doaj   +1 more source

Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability

Acta Pharmaceutica Sinica B, 2023
Our recent studies for nonnucleoside reverse transcriptase inhibitors identified a highly potent compound JK-4b against WT HIV-1 (EC50 = 1.0 nmol/L), but the poor metabolic stability in human liver microsomes (t1/2 = 14.6 min) and insufficient ...
Xin Jin, Shuai Wang, Limin Zhao, Wenjuan Huang, Yinxiang Zhang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Huri Piao, Fener Chen   +9 more
doaj   +1 more source

Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability

Acta Pharmaceutica Sinica B, 2023
Considering the undesirable metabolic stability of our recently identified NNRTI 5 (t1/2 = 96 min) in human liver microsomes, we directed our efforts to improve its metabolic stability by introducing a new favorable hydroxymethyl side chain to the C-5 ...
Ya-Li Sang, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen   +4 more
doaj   +1 more source

Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility

Acta Pharmaceutica Sinica B, 2023
Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66 (SI = 2019.80, S = 1.9 μg/mL), a series of novel heterocycle-substituted ATDP derivatives with significantly improved selectivity and solubility were ...
Li-Min Zhao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen   +4 more
doaj   +1 more source

Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Acta Pharmaceutica Sinica B, 2020
In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines (NP-DATAs), synthesis of a series of novel biphenyl-substituted diaryltriazines (BP-DATAs) with a flexible side chain attached at the C-6 position is ...
Kaijun Jin, Minjie Liu, Chunlin Zhuang, Erik De Clercq, Christophe Pannecouque, Ge Meng, Fener Chen   +6 more
doaj   +1 more source

Asymmetric Total Synthesis of Vindoline

, 2016
Asymmetric Total Synthesis of ...
Dale L. Boger (1306542), Daisuke Kato (1827106), Yoshikazu Sasaki (1809736)   +2 more
core   +3 more sources