Results 71 to 80 of about 3,217 (192)

Nitration of GlcCer and Related Complex Lipids Enhances CD1d Binding Affinity and Modulates Immune Responses via Lipid Antigen Presentation to Natural Killer T Cells

ChemistryEurope, Volume 4, Issue 1, January 2026.
Nitration of glycolipids and phospholipids increases their binding to CD1d. Nitrated β‐GlcCer and phospholipids show strong CD1d binding but induce minimal cytokine production, suggesting potential immune suppression. In contrast, nitrated endogenous‐type α‐GalCer enhances cytokine responses, indicating that nitrated lipids can modulate CD1d‐mediated ...
Kodai Sueyoshi, Nanako Kawate‐Horiuchi, Kazunari Ueki, Risa Nozawa, Takanori Matsumaru, Yukari Fujimoto   +5 more
wiley   +1 more source

Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2

Communications Chemistry
The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (Mpro) represents one of the most attractive targets for the development of antiviral drugs.
Francisco J. Medrano, Sergio de la Hoz-Rodríguez, Sergio Martí, Kemel Arafet, Tanja Schirmeister, Stefan J. Hammerschmidt, Christin Müller, Águeda González-Martínez, Elena Santillana, John Ziebuhr, Antonio Romero, Collin Zimmer, Annabelle Weldert, Robert Zimmermann, Alessio Lodola, Katarzyna Świderek, Vicent Moliner, Florenci V. González   +17 more
doaj   +1 more source

Protective Effects of Nitrated Fatty Acids from Olive Oil on Cardiovascular Risk in Non-Alcoholic Fatty Liver Disease

Agrociencia Uruguay
Non-alcoholic fatty liver disease (NAFLD) is defined by the deposition of fat in the liver without alcohol consumption. Moreover, it is the most prevalent chronic liver disease worldwide and is associated with an increased risk of cardiovascular disease.
Beatriz Sánchez-Calvo, Adriana Cassina, Homero Rubbo, Andrés Trostchansky   +3 more
doaj   +1 more source

Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine[S]

Journal of Lipid Research, 2013
The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein constituents into mediators that regulate signal transduction.
Sonia R. Salvatore, Dario A. Vitturi, Paul R.S. Baker, Gustavo Bonacci, Jeffrey R. Koenitzer, Steven R. Woodcock, Bruce A. Freeman, Francisco J. Schopfer   +7 more
doaj   +1 more source

A Greener, Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

Molecules, 2014
An efficient method for the synthesis of a variety of pyrimidine derivatives 3a–t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a–k as Michael acceptor using an aqueous medium and diethylamine is described.
Hany J. Al-Najjar, Assem Barakat, Abdullah M. Al-Majid, Yahia N. Mabkhot, Manuel Weber, Hazem A. Ghabbour, Hoong-Kun Fun   +6 more
doaj   +1 more source

Synthesis, X-ray Diffraction, Thermogravimetric and DFT Analyses of Pyrimidine Derivatives

Molecules, 2014
An eco-benign synthesis of pyrimidine derivatives 2a,b containing different functional groups with different electronic character starting from nitroalkenes 1a and 2b has been described.
Assem Barakat, Hany J. Al-Najjar, Abdullah M. Al-Majid, Syed F. Adil, Mohamed Ali, Vijay H. Masand, Hazem A Ghabbour, Hoong-Kun Fun   +7 more
doaj   +1 more source

Part II: Nitroalkenes in the synthesis of heterocyclic compounds

, 2014
This part (part II) is devoted to 6-membered heterocycles that are synthesized from nitroalkenes as the key substrates. These compounds can be simply accessible to form nitroalkenes and C, O, N or S-nucleophiles bearing a suitable leaving group via a ...
Halimehjani, Azim Ziyaei, Hooshmand, Seyyed Emad, Namboothiri, Irishi N. N.   +2 more
core   +1 more source

Conjugate addition of indoles to nitroalkenes promoted by basic alumina in solventless conditions

, 2006
Basic alumina is found to promote the conjugate addition of indoles to nitroalkenes in solventless conditions at 60° C. Nitroalkenes can be replaced by nitro alcohols that are converted into nitroolefins under the reaction conditions.
PETRINI, Marino, RABANEDO CLEMENTE R., BALLINI, Roberto, PALMIERI, Alessandro   +3 more
core   +2 more sources

Fe-Catalyzed Reductive Coupling of Unactivated Alkenes with β‑Nitroalkenes

, 2015
An Fe-catalyzed reductive coupling of unactivated alkenes with β-nitroalkenes has been developed. The reaction proceeds through a radical pathway, with β-nitroalkenes serving as the vinylating reagents and the nitro group being cleaved in the process ...
Jing Zheng (65946), Dahai Wang (43134), Sunliang Cui (1447630)   +2 more
core   +1 more source

Phosphonylpyrazoles from Bestmann−Ohira Reagent and Nitroalkenes: Synthesis and Dynamic NMR Studies

, 2016
Application of diethyl 1-diazo-2-oxopropylphosphonate (Bestmann−Ohira reagent) as a cycloaddition partner with nitroalkenes has been extensively investigated.
Rajendran Muruganantham (2308390), Irishi Namboothiri (2308387)   +1 more
core   +2 more sources