Results 1 to 10 of about 665,789 (291)

Aggregation-Induced Catalysis: Asymmetric Catalysis with Chiral Aggregates [PDF]

Research, 2023
So far, there have been 4 methods to control chirality including the use of chiral auxiliaries, reagents, solvents, and catalysts documented in literature and textbooks.
Yao Tang, Yu Wang, Qingkai Yuan, Sai Zhang, Jia-Yin Wang, Shengzhou Jin, Ting Xu, Junyi Pan, Kazimierz Surowiec, Guigen Li   +9 more
doaj   +3 more sources

Benchmarking molecular representations and machine learning algorithms for asymmetric catalysis: a palladium-catalysed decarboxylative asymmetric allylic alkylation case study [PDF]

Journal of Cheminformatics
Machine learning (ML) applied to metal-ligand asymmetric catalysis remains less explored compared to other applications, such as drug design or materials science. Current strategies frequently focus on augmenting pre-existing descriptors (e.g.
Eduardo Aguilar-Bejarano, Declan Galvin, David M. Rogers, Ender Özcan, Simon Woodward, Patrick J. Guiry, Grazziela Figueredo   +6 more
doaj   +2 more sources

Synthesis of Homochiral N‐Heterocyclic Carbene‐Based Nanosheets for Enhanced Asymmetric Catalysis [PDF]

Advanced Science
Utilizing ultrathin 2D metal–organic framework nanosheets (2D MONs) as supports for incorporating chiral catalysts represents a highly promising avenue in the field of asymmetric catalysis.
Xinchao Wang, Zhiwen Wang, Zhaoxing Wang, Tian‐Fu Liu, Shangda Li, Fei Wang, Jian Zhang   +6 more
doaj   +2 more sources

Synthesis of novel phthalimido oxime pseudoesters and evaluation of their cytotoxicity [PDF]

Journal of the Serbian Chemical Society, 2020
A series of novel optically pure oxime pseudoesters derivatives were synthesized by the reaction of substitute keto oximes with various N-substituted α-amino acids chlorides in the presence of triethylamine and dichloromethane at 0°C, and their ...
Mehrez Asma, Chakroun Ibtissem, Mtat Dalila, Ben Mansour Hédi, Touati Ridha   +4 more
doaj   +1 more source

Synergistic Pd/Cu catalysis for stereoselective allylation of vinylethylene carbonates with glycine iminoesters: Enantioselective access to diverse trisubstituted allylic amino acid derivatives

Green Synthesis and Catalysis, 2021
We reported a synergistic Pd/Cu catalyzed enantioselective decarboxylative allylation of vinylethylene carbonates with glycine iminoesters, which provides facile access to non-proteinogenic diverse trisubstituted allylic amino acid derivatives in high ...
Miaolin Ke, Zhigang Liu, Ke Zhang, Sheng Zuo, Fener Chen   +4 more
doaj   +1 more source

Continuous-Flow Synthesis of the Nucleobase Unit of Remdesivir

Engineering, 2023
In this work, the nucleobase unit of the antiviral drug remdesivir, 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, was synthesized through five-step continuous flow.
Yongxing Guo, Minjie Liu, Meifen Jiang, Yuan Tao, Dang Cheng, Fen-Er Chen   +5 more
doaj   +1 more source

Nickel-catalyzed direct stereoselective α-allylation of ketones with non-conjugated dienes

Nature Communications, 2023
The development of efficient and sustainable methods for the construction of carbon-carbon bonds with the simultaneous stereoselective generation of vicinal stereogenic centers is a longstanding goal in organic chemistry.
Yi-Xuan Cao, Matthew D. Wodrich, Nicolai Cramer   +2 more
doaj   +1 more source

Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability

Acta Pharmaceutica Sinica B, 2023
Considering the undesirable metabolic stability of our recently identified NNRTI 5 (t1/2 = 96 min) in human liver microsomes, we directed our efforts to improve its metabolic stability by introducing a new favorable hydroxymethyl side chain to the C-5 ...
Ya-Li Sang, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen   +4 more
doaj   +1 more source

Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability

Acta Pharmaceutica Sinica B, 2023
Our recent studies for nonnucleoside reverse transcriptase inhibitors identified a highly potent compound JK-4b against WT HIV-1 (EC50 = 1.0 nmol/L), but the poor metabolic stability in human liver microsomes (t1/2 = 14.6 min) and insufficient ...
Xin Jin, Shuai Wang, Limin Zhao, Wenjuan Huang, Yinxiang Zhang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Huri Piao, Fener Chen   +9 more
doaj   +1 more source

Transition metal-catalyzed branch-selective hydroformylation of olefins in organic synthesis

Green Synthesis and Catalysis, 2021
Hydroformylation of olefins can generate linear and branched aldehydes, and the branched aldehydes are attractive precursors for the synthesis of fine chemicals and pharmaceuticals.
Yingtang Ning, Tomohiko Ohwada, Fen-Er Chen   +2 more
doaj   +1 more source