Results 21 to 30 of about 47,960 (298)

Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility

Acta Pharmaceutica Sinica B, 2023
Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66 (SI = 2019.80, S = 1.9 μg/mL), a series of novel heterocycle-substituted ATDP derivatives with significantly improved selectivity and solubility were ...
Li-Min Zhao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen   +4 more
doaj   +1 more source

Asymmetric Ion‐Pairing Catalysis [PDF]

Angewandte Chemie International Edition, 2012
AbstractCharged intermediates and reagents are ubiquitous in organic transformations. The interaction of these ionic species with chiral neutral, anionic, or cationic small molecules has emerged as a powerful strategy for catalytic, enantioselective synthesis.
Brak, Katrien, Jacobsen, Eric
openaire   +4 more sources

Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Acta Pharmaceutica Sinica B, 2020
In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines (NP-DATAs), synthesis of a series of novel biphenyl-substituted diaryltriazines (BP-DATAs) with a flexible side chain attached at the C-6 position is ...
Kaijun Jin, Minjie Liu, Chunlin Zhuang, Erik De Clercq, Christophe Pannecouque, Ge Meng, Fener Chen   +6 more
doaj   +1 more source

Supramolecular asymmetric catalysis mediated by crown ethers and related recognition systems

Green Synthesis and Catalysis, 2021
In the past decades, the combination of supramolecular chemistry and catalysis has pushed forward the emergence of supramolecular catalysis as an intersectant and challenging research field.
Zibin Zhang, Yuanguang Shao, Jiadong Tang, Juli Jiang, Leyong Wang, Shijun Li   +5 more
doaj   +1 more source

Advances in Versatile Chiral Ligands for Asymmetric Gold Catalysis

, 2023
The formation of valuable chiral skeletons through asymmetric gold catalysis has made considerable progress due to the unrivaled affinity of gold complexes with multiple carbon–carbon bonds.
Rui Zhang, Hui Yang, Yufeng Wu, Haojie Gao, Liyuan Geng, Xiaoyi Huang   +5 more
core   +1 more source

Asymmetric Catalysis by Flavin Dependent Halogenases

, 2022
In nature, flavin dependent halogenases (FDHs) catalyze site-selective chlorination and bromination of aromatic natural products. This ability has led to extensive efforts to engineer FDHs for selective chlorination, bromination, and iodination of ...
Yuhua, Jiang, Jared C., Lewis
core   +1 more source

Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols

iScience, 2018
Summary: Chiral syn-1,3-diols are fundamental structural motifs in many natural products and drugs. The traditional Narasaka-Prasad diastereoselective reduction from chiral β-hydroxyketones is an important process for the synthesis of these ...
Guanxin Huang, Minjie Liu, Fangjun Xiong, Ge Meng, Yuan Tao, Yan Wu, Haihui Peng, Fener Chen   +7 more
doaj   +1 more source

Application of MOFs in asymmetric catalysis

上海师范大学学报. 自然科学版, 2023
So far, metal-organic frameworks(MOFs) have been developed in many fields, including gas adsorption, catalysis, and other directions. In recent years, due to the rapid development of asymmetric catalysis, chiral MOFs in stereoselective catalysis has ...
ZHANG Xiang, TAN Chunxia, LIN Jingrong
doaj   +1 more source

Recycling in Asymmetric Catalysis [PDF]

Accounts of Chemical Research, 2016
Cyclic reaction networks consisting of an enantioselective product-forming step and a reverse reaction of the undesired enantiomer back to starting reactant are important for the generation of compounds with high enantiomeric purity. In order to avoid an equilibrium racemic state, a unidirectional cyclic process where product formation and regeneration
openaire   +2 more sources

Data-driven catalyst optimization for stereodivergent asymmetric synthesis by iridium/boron hybrid catalysis

Cell Reports Physical Science, 2021
Summary: Asymmetric catalysis enabling divergent control of multiple stereocenters remains challenging in synthetic organic chemistry. Although machine-learning-based optimization of molecular catalysis is a rapidly growing research field, the use of ...
Hongyu Chen, Shigeru Yamaguchi, Yuya Morita, Hiroyasu Nakao, Xiangning Zhai, Yohei Shimizu, Harunobu Mitsunuma, Motomu Kanai   +7 more
doaj   +1 more source