Results 31 to 40 of about 665,789 (291)

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

Acta Pharmaceutica Sinica B, 2020
Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the cornerstone of HIV treatment.
Chunlin Zhuang, Christophe Pannecouque, Erik De Clercq, Fener Chen   +3 more
doaj   +1 more source

Electricity-driven asymmetric bromocyclization enabled by chiral phosphate anion phase-transfer catalysis

Nature Communications, 2023
Asymmetric electrochemical synthesis via ion-pairing catalysis is challenging due to interference of the electrolyte with the ion-pairing catalyst.
Xuefeng Tan, Qingli Wang, Jianwei Sun
doaj   +1 more source

Data-driven catalyst optimization for stereodivergent asymmetric synthesis by iridium/boron hybrid catalysis

Cell Reports Physical Science, 2021
Summary: Asymmetric catalysis enabling divergent control of multiple stereocenters remains challenging in synthetic organic chemistry. Although machine-learning-based optimization of molecular catalysis is a rapidly growing research field, the use of ...
Hongyu Chen, Shigeru Yamaguchi, Yuya Morita, Hiroyasu Nakao, Xiangning Zhai, Yohei Shimizu, Harunobu Mitsunuma, Motomu Kanai   +7 more
doaj   +1 more source

Non-linear Effects in Asymmetric Catalysis: Whys and Wherefores [PDF]

, 2012
It is argued that the titled non-linear effects (NLE) may arise whenever the order of the reaction in the chiral catalyst in greater than 1. In a fundamental departure from previous approaches, this is mathematically elaborated for the second order case.
Sosale Chandrasekhar
core   +1 more source

Asymmetric catalysis in synthetic strategies for chiral benzothiazepines

Green Synthesis and Catalysis, 2020
Chiral benzothiazepines constitute the core structures of many foremost pharmaceuticals with diverse biological activities endowed by their unique scaffolds, which poses a great challenge to organic chemists and pharmaceutical researchers.
Haifeng Wang, Shuangxi Gu, Qiongjiao Yan, Li Ding, Fen-Er Chen   +4 more
doaj   +1 more source

Harnessing noncovalent interaction of chalcogen bond in organocatalysis: From the catalyst point of view

Green Synthesis and Catalysis, 2021
The introduction of new interactions into organic transformation is an objective of fundamental importance. Chalcogen bond has emerged as an unconventional type of noncovalent interaction which provides a useful synthetic tool for organocatalysis and has
Weitao Yan, Mingwen Zheng, Chunfa Xu, Fen-Er Chen   +3 more
doaj   +1 more source

New Trends in Asymmetric Catalysis [PDF]

Catalysts, 2021
As far back as the mid-nineteenth century, the studies of Louis Pasteur brought to light the essential role of molecular chirality in biology [...]
Schettini R., Sala G. D.
openaire   +2 more sources

Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis

Frontiers in Chemistry, 2022
Transition metal catalysis plays an essential role in the total synthesis of natural products. Cobalt-mediated asymmetric catalysis has successfully been used as a primary or a secondary step in the total synthesis of natural products, especially ...
Shu Xiao, Likun Ai, Qichang Liu, Baihui Yang, Jian Huang, Wei Xue, Yang Chen   +6 more
doaj   +1 more source

Computational and Experimental Studies on the α-Functionalization of Ketones Using Domino Reactions: A Strategy to Increase Chemoselectivity at the α-Carbon of Ketones

Molecules
A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in the α-functionalization of ketones.
Hui Sun, Li-Heng Yang, Meng-Yun Fu, Bin Cui   +3 more
doaj   +1 more source

Recent advances in the total synthesis of monoterpenoid indole alkaloids enabled by asymmetric catalysis

Green Synthesis and Catalysis, 2022
Asymmetric catalysis has continued to enable the preparation of optically active natural products over the past decade. This minireview summarizes progress in the catalytic enantioselective total synthesis of complex monoterpenoid indole alkaloids ...
Xiao-Yu Liu, Yong Qin
doaj   +1 more source