Results 31 to 40 of about 37,655 (255)

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

Acta Pharmaceutica Sinica B, 2020
Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the cornerstone of HIV treatment.
Chunlin Zhuang, Christophe Pannecouque, Erik De Clercq, Fener Chen   +3 more
doaj   +1 more source

New Trends in Asymmetric Catalysis [PDF]

Catalysts, 2021
As far back as the mid-nineteenth century, the studies of Louis Pasteur brought to light the essential role of molecular chirality in biology [...]
Schettini R., Sala G. D.
openaire   +2 more sources

Asymmetric catalysis in synthetic strategies for chiral benzothiazepines

Green Synthesis and Catalysis, 2020
Chiral benzothiazepines constitute the core structures of many foremost pharmaceuticals with diverse biological activities endowed by their unique scaffolds, which poses a great challenge to organic chemists and pharmaceutical researchers.
Haifeng Wang, Shuangxi Gu, Qiongjiao Yan, Li Ding, Fen-Er Chen   +4 more
doaj   +1 more source

Harnessing noncovalent interaction of chalcogen bond in organocatalysis: From the catalyst point of view

Green Synthesis and Catalysis, 2021
The introduction of new interactions into organic transformation is an objective of fundamental importance. Chalcogen bond has emerged as an unconventional type of noncovalent interaction which provides a useful synthetic tool for organocatalysis and has
Weitao Yan, Mingwen Zheng, Chunfa Xu, Fen-Er Chen   +3 more
doaj   +1 more source

Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis

Frontiers in Chemistry, 2022
Transition metal catalysis plays an essential role in the total synthesis of natural products. Cobalt-mediated asymmetric catalysis has successfully been used as a primary or a secondary step in the total synthesis of natural products, especially ...
Shu Xiao, Likun Ai, Qichang Liu, Baihui Yang, Jian Huang, Wei Xue, Yang Chen   +6 more
doaj   +1 more source

Recent advances in the total synthesis of monoterpenoid indole alkaloids enabled by asymmetric catalysis

Green Synthesis and Catalysis, 2022
Asymmetric catalysis has continued to enable the preparation of optically active natural products over the past decade. This minireview summarizes progress in the catalytic enantioselective total synthesis of complex monoterpenoid indole alkaloids ...
Xiao-Yu Liu, Yong Qin
doaj   +1 more source

Computational and Experimental Studies on the α-Functionalization of Ketones Using Domino Reactions: A Strategy to Increase Chemoselectivity at the α-Carbon of Ketones

Molecules
A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in the α-functionalization of ketones.
Hui Sun, Li-Heng Yang, Meng-Yun Fu, Bin Cui   +3 more
doaj   +1 more source

Progress in Stereoselective Haloamination of Olefins

Molecules
The regio- and stereoselective adjacent bifunctionalization of olefins with amine and halogen groups can be effectively accomplished through catalytic haloamination methods.
Guo Zhong, Jiayu Zhou, Bin Cui, Hui Sun
doaj   +1 more source

Copper(I)-catalyzed asymmetric alkylation of α-imino-esters

Nature Communications, 2023
Asymmetric alkylation of enolates is one of the most direct and important reactions to prepare α-chiral carbonyl compounds. Except for the classical methods that rely on the use of chiral auxiliaries, asymmetric catalysis emerged as a powerful tool ...
Zong-Ci Liu, Zi-Qing Wang, Xuan Zhang, Liang Yin   +3 more
doaj   +1 more source

An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1

Engineering
Vitamin B1 is widely applied in the healthcare and food industry as an antineuritic and antioxidant to maintain the normal functioning of nerve conduction, the heart, and the gastrointestinal tract.
Meifen Jiang, Minjie Liu, Weijian Li, Yingqi Xia, Fen-Er Chen   +4 more
doaj   +1 more source