Results 51 to 60 of about 47,960 (298)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Le limonène dans les huiles essentielles  : énantiomères et activités biologiques

Comptes Rendus. Chimie
Literature data are used to identify the enantiomeric diversity of limonene in 54 essential oils composed of between 0.3–99.7% of this molecule. Significant enantiomeric excesses are observed, either in (R)-(+)-, or in (S)-(–)-limonene, and more rarely ...
Aribi-Zouioueche, Louisa
doaj   +1 more source

Research progress of chiral rare earth complexes in asymmetric catalysis

上海师范大学学报. 自然科学版, 2017
With the increasing demand of the optical compounds,asymmetric catalysis becomes a hot research area.The rare earth elements are defined as the elements of lanthanide from La to Lu,together with Sc and Y.Compared to the orbital interaction between the ...
Chou Yajie, Cheng Tanyu, Lin Jingrong
doaj   +1 more source

Artificial Metalloenzymes in Asymmetric Catalysis: Key Developments and Future Directions

, 2015
Em enviat el pdf de l'article, pero disposem tant del preprint com el postprint.Artificial Metalloenzymes in Asymmetric Catalysis: Key Developments and Future ...
Jan-E. Bäckvall, PAMIES OLLÉ, OSCAR, Pàmies, Oscar, Bäckvall, Jan-E.,, Diéguez, Montserrat, DIÉGUEZ FERNÁNDEZ, MONTSERRAT   +5 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Catalytic enantioselective intramolecular hydroamination of alkenes using chiral aprotic cyclic urea ligand on manganese (II)

Nature Communications
Asymmetric catalysis for enantioselective intramolecular hydroamination of alkenes is a critical method in the construction of enantioenriched nitrogen-containing rings, often prevalent in biologically active compounds and natural products.
Bin Cui, Yuting Zheng, Hui Sun, Huijian Shang, Man Du, Yuxuan Shang, Cafer T. Yavuz   +6 more
doaj   +1 more source

Recent developments in transition metal-catalyzed asymmetric borrowing hydrogen catalysis

Tetrahedron Chem, 2023
Asymmetric Borrowing Hydrogen (BH) catalysis is a versatile, one-step approach for synthesizing enantioenriched amines/carbonyl derivatives from biomass-derived oxidized hydrocarbons with water as the sole by-product.
Nidhi Garg, Ishika Agrawal, Dhananjay Satav, Doppalapudi Vineet Kumar, Basker Sundararaju   +4 more
doaj   +1 more source

Asymmetric catalysis with metal complexes in nanoreactors

, 2008
Recently, the field of heterogeneous asymmetric catalysis, generally using chiral solid catalysts, has attracted much attention in the production of single enantiomers.
Yang, Hengquan, Yang, Qihua, Li, Can, 李灿, Han, Difei   +4 more
core   +1 more source

An Experimental High‐Throughput Approach for the Screening of Hard Magnet Materials

Advanced Engineering Materials, EarlyView.
An entire workflow for the high‐throughput characterization and analysis of compositionally graded magnetic films is presented. Characterization protocols, data management tools and data analysis approaches are illustrated with test case Sm(Fe, V)12 based films.
William Rigaut, Pierre Le Berre, Hamdi Jaballah, Lukas Fink, Victor Poline, Richard Haettel, Stéphane Grenier, Gilbert Chahine, Ewen Bellec, Guillaume Buatier, Wilfried Hortschitz, Santa Pile, Thomas Schrefl, Nils Blanc, Yuan Hong, Thibaut Devillers, Nora M. Dempsey   +16 more
wiley   +1 more source

DNA-Based asymmetric catalysis as a synthetic tool [PDF]

, 2012
De helische structuur van DNA heeft altijd al aantrekkingskracht gehad op chemici. In onze groep hebben we DNA gebruikt om een enantioselectieve katalysator te ontwikkelen.
Megens, Rikkert Pepijn,, Megens, Rikkert Pepijn   +1 more
core