Results 71 to 80 of about 637,304 (300)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Unlocking the potential of oxidative asymmetric catalysis with continuous flow electrochemistry [PDF]

, 2023
In the field of catalytic asymmetric synthesis, the less-treaded path lies in oxidative catalytic asymmetric transformations. The hurdles of pinpointing appropriate chemical oxidants and addressing their compatibility issues with catalysts and ...
Liang-Hua, Jie, Hai-Chao, Xu, Peng-Yu, Chen, Bin, Guo, Chong, Huang, Shaobin, Zhu   +5 more
core   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Heterogenisation of ketone catalysts within mesoporous supports for asymmetric epoxidation

, 2013
The synthesis of the first mesoporous silica (150 Å) anchored carbohydrate-derived chiral ketone is described. This new heterogeneous catalyst has been shown to be effective in the asymmetric epoxidation of olefins by oxone.
Robert Raja, Raja, Robert, Lynda J. Brown, Brown, Lynda J., Richard C. D. Brown, Brown, Richard C.D.   +5 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β

Marine Drugs, 2021
Glycogen synthase kinase 3β (GSK-3β) is a widely investigated molecular target for numerous diseases, and inhibition of GSK-3β activity has become an attractive approach for the treatment of diabetes.
Shuwen Han, Chunlin Zhuang, Wei Zhou, Fener Chen   +3 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Enantioselective Heterogeneous Synergistic Catalysis for Asymmetric Cascade Transformations

, 2014
A modular design for a novel heterogeneous synergistic catalytic system, which simultaneously activates the electrophile and nucleophile by the combined activation modes of a separate metal and non-metal catalyst, for asymmetric cascade transformations ...
Ghisu, Lorenza,, Eric V. Johnston, Bacsik, Zoltan,, Niklas Hedin, Johnston, Eric V.,, Samson Afewerki, Lorenza Ghisu, Zoltan Bacsik, Deiana, Luca,, Luca Deiana, Afewerki, Samson,, Armando Córdova, Cordova, Armando,, Hedin, Niklas,, Verho, Oscar,, Oscar Verho, Afewerki, Samson   +16 more
core   +1 more source

Observation of Hyperpositive Non-Linear Effects in Asymmetric Catalysis [PDF]

, 2019
Asymmetric amplification is a phenomenon that plays a key role in the emergence of homochirality in life. In asymmetric catalysis, theoretical and experimental models have been investigated for understanding how chiral amplification is possible, in ...
Yannick, Geiger, Stephane, Bellemin-Laponnaz, thierry, achard, aline, maisse-françois   +3 more
core   +2 more sources

Bio‐Inspired Synthesis of Macroporous Single Crystal Particles as Scattering Agents

Advanced Functional Materials, EarlyView.
A general strategy is presented that delivers unique, single‐crystal microparticles that combine submicron macroporosity and uniform particle shapes. A bioinspired approach is used to occlude three distinct types of additives – polystyrene microspheres, polymer vesicles and amino acids – within calcite single crystals, and subsequent thermal annealing ...
Stephanie E. Foster, Gianni Jacucci, Ouassef Nahi, Thomas Kress, Zabeada Aslam, Stuart Micklethwaite, Alexander N. Kulak, Rik Drummond‐Brydson, Melinda J. Duer, Yi‐Yeoun Kim, Silvia Vignolini, Fiona C. Meldrum   +11 more
wiley   +1 more source