Results 41 to 50 of about 47,960 (298)

Progress in Stereoselective Haloamination of Olefins

Molecules
The regio- and stereoselective adjacent bifunctionalization of olefins with amine and halogen groups can be effectively accomplished through catalytic haloamination methods.
Guo Zhong, Jiayu Zhou, Bin Cui, Hui Sun
doaj   +1 more source

Copper(I)-catalyzed asymmetric alkylation of α-imino-esters

Nature Communications, 2023
Asymmetric alkylation of enolates is one of the most direct and important reactions to prepare α-chiral carbonyl compounds. Except for the classical methods that rely on the use of chiral auxiliaries, asymmetric catalysis emerged as a powerful tool ...
Zong-Ci Liu, Zi-Qing Wang, Xuan Zhang, Liang Yin   +3 more
doaj   +1 more source

Non-linear Effects in Asymmetric Catalysis: Whys and Wherefores

, 2012
It is argued that the titled non-linear effects (NLE) may arise whenever the order of the reaction in the chiral catalyst in greater than 1. In a fundamental departure from previous approaches, this is mathematically elaborated for the second order case.
Sosale Chandrasekhar
core   +1 more source

Chiral pyridyl phosphinite catalysts and the development of structure selectivity relationships in the asymmetric hydrogenation of trisubstituted alkenes [PDF]

, 2010
The current trend in developing asymmetric catalysts is towards creating specialized molecules with tailored functions for increased selectivity in classes of substrates rather than general catalysts capable of broad application.
Woodmansee, David Harrison
core   +1 more source

An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1

Engineering
Vitamin B1 is widely applied in the healthcare and food industry as an antineuritic and antioxidant to maintain the normal functioning of nerve conduction, the heart, and the gastrointestinal tract.
Meifen Jiang, Minjie Liu, Weijian Li, Yingqi Xia, Fen-Er Chen   +4 more
doaj   +1 more source

Asymmetric synthesis of tri- and tetrasubstituted trifluoromethyl dihydropyranones from alpha-aroyloxyaldehydes via NHC redox catalysis

, 2014
We thank the Royal Society for a University Research Fellowship (A.D.S.), and the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC Grant Agreement No.
Smith, Andrew D., Philip M. Pickett, Philip M. Pickett (1771471), Alexandra M. Z. Slawin (809268), Alyn T. Davies (1771468), Andrew D. Smith, Davies, Alyn T., Pickett, Philip M., Alexandra M. Z. Slawin, Slawin, Alexandra M. Z., Alyn T. Davies, Andrew D. Smith (494170)   +11 more
core   +1 more source

Asymmetric electrocyclic reactions

, 2013
Pericyclic reactions are a class of transformations that comprise sigmatropic rearrangements, group transfer reactions, cycloadditions and electrocyclic reactions.
Maciver, Eleanor E
core   +1 more source

Asymmetric catalysis: An enabling science [PDF]

Proceedings of the National Academy of Sciences, 2004
Chirality of organic molecules plays an enormous role in areas ranging from medicine to material science, yet the synthesis of such entities in one enantiomeric form is one of the most difficult challenges. The advances being made stem from the convergence of a broader understanding of theory and how structure begets function, the developments in the ...
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source