Results 41 to 50 of about 37,655 (255)
Asymmetric catalysis: An enabling science [PDF]
Proceedings of the National Academy of Sciences, 2004 Chirality of organic molecules plays an enormous role in areas ranging from medicine to material science, yet the synthesis of such entities in one enantiomeric form is one of the most difficult challenges. The advances being made stem from the convergence of a broader understanding of theory and how structure begets function, the developments in the ...
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Le limonène dans les huiles essentielles : énantiomères et activités biologiques
Comptes Rendus. ChimieLiterature data are used to identify the enantiomeric diversity of limonene in 54 essential oils composed of between 0.3–99.7% of this molecule. Significant enantiomeric excesses are observed, either in (R)-(+)-, or in (S)-(–)-limonene, and more rarely ...
Aribi-Zouioueche, Louisa
doaj +1 more source
Research progress of chiral rare earth complexes in asymmetric catalysis
上海师范大学学报. 自然科学版, 2017 With the increasing demand of the optical compounds,asymmetric catalysis becomes a hot research area.The rare earth elements are defined as the elements of lanthanide from La to Lu,together with Sc and Y.Compared to the orbital interaction between the ...
Chou Yajie, Cheng Tanyu, Lin Jingrong
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Nature CommunicationsAsymmetric catalysis for enantioselective intramolecular hydroamination of alkenes is a critical method in the construction of enantioenriched nitrogen-containing rings, often prevalent in biologically active compounds and natural products.
Bin Cui +6 more
doaj +1 more source
Recent developments in transition metal-catalyzed asymmetric borrowing hydrogen catalysis
Tetrahedron Chem, 2023 Asymmetric Borrowing Hydrogen (BH) catalysis is a versatile, one-step approach for synthesizing enantioenriched amines/carbonyl derivatives from biomass-derived oxidized hydrocarbons with water as the sole by-product.
Nidhi Garg +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source