Results 1 to 10 of about 4,503 (197)

Development of nitroalkene-based inhibitors to target STING-dependent inflammation [PDF]

Redox Biology
Stimulator of Interferon Genes (STING) is essential for the inflammatory response to cytosolic DNA. Despite that aberrant activation of STING is linked to an increasing number of inflammatory diseases, the development of inhibitors has been challenging ...
Anne Louise Hansen
exaly   +4 more sources

Nitroalkene inhibition of pro-inflammatory macrophage effector function via modulation of signaling metabolite levels [PDF]

Frontiers in Physiology
IntroductionClassically activated innate immune cells undergo a metabolic switch to aerobic glycolysis to support effector function. We report that the small-molecule nitroalkene 10-n-octadec-9-enoic acid (NO2-OA) attenuates the Warburg- like phenotype ...
Emily R. Stevenson, James P. O’Brien, Allison M. Manuel, Crystal E. Uvalle, Gregory J. Buchan, Steven J. Mullett, Steven J. Mullett, Karina Lockwood, Tomeka Suber, Bruce A. Freeman, Stacy L. Gelhaus, Stacy L. Gelhaus   +11 more
doaj   +4 more sources

The Puzzle of the New Type of Intermediate in the Course of [2 + 2] Cycloaddition with the Participation of Conjugated Nitroalkenes: MEDT Computational Study [PDF]

Molecules
The phenomena of regio- and stereoselectivity and the molecular mechanism of the [2 + 2] cycloaddition reaction between (E)-2-arylnitroethenes and the ynamine molecular system were analyzed using wb97xd/6-311 + G(d) (PCM) quantumchemical calculations. It
Radomir Jasiński, Agnieszka Kącka-Zych
doaj   +4 more sources

Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine[S] [PDF]

Journal of Lipid Research, 2013
The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein constituents into mediators that regulate signal transduction.
Sonia R. Salvatore, Dario A. Vitturi, Paul R.S. Baker, Gustavo Bonacci, Jeffrey R. Koenitzer, Steven R. Woodcock, Bruce A. Freeman, Francisco J. Schopfer   +7 more
doaj   +2 more sources

Fatty Acid and Amino Acid Derivatives in Organocatalyzed Michael Additions [PDF]

Molecules
Amino acid derivatives, such as β-keto esters and pyrrolones, were used as nucleophiles in organocatalyzed Michael additions to nitroalkene acceptors, while fatty acid derivatives acted as both nucleophiles (β-keto esters) and electrophiles (nitroalkene ...
Aljaž Flis, Helena Brodnik, Nejc Petek, Franc Požgan, Jurij Svete, Bogdan Štefane, Luka Ciber, Uroš Grošelj   +7 more
doaj   +2 more sources

Enantioselective addition of aryl ketones and acetone to nitroalkenes organocatalyzed by carbamate-monoprotected cyclohexa-1,2-diamines [PDF]

, 2015
Enantiomerically pure carbamate-monoprotected trans-cyclohexane-1,2-diamines are used as chiral organocatalysts for the addition of aryl ketones and acetone to nitroalkenes to give enantioenriched β-substituted γ-nitroketones.
Chinchilla, Rafael, Flores Ferrándiz, Jesús, Gómez Bengoa, Enrique, Sotorríos, Lia, Stiven, Alexander   +4 more
core   +3 more sources

Electrophilic characteristics and aqueous behavior of fatty acid nitroalkenes

Redox Biology, 2021
Fatty acid nitroalkenes (NO2-FA) are endogenously-generated products of the reaction of metabolic and inflammatory-derived nitrogen dioxide (.NO2) with unsaturated fatty acids.
Valentina Grippo, Milos Mojovic, Aleksandra Pavicevic, Martin Kabelac, Frantisek Hubatka, Jaroslav Turanek, Martina Zatloukalova, Bruce A. Freeman, Jan Vacek   +8 more
doaj   +2 more sources

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]

, 2014
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff, Bonacci, Gustavo Roberto, Cantu Medellin, Nadiezhda, Champion, Hunter C., Croix, Claudette M. St., Devlin, Jason E., Freeman, Bruce A., Frisbee,Jefferson C., Gladwin, Mark T., Golin Bisello, Franca, Gor, Sonia, Kelley, Eric E., Khoo, Nicholas K.H., Watkins, Simon C., Weidert, Eric R.   +14 more
core   +3 more sources

Understanding the Molecular Mechanism of Thermal and LA-Catalysed Diels–Alder Reactions between Cyclopentadiene and Isopropyl 3-Nitroprop-2-Enate [PDF]

Molecules, 2023
The molecular mechanism of the Diels–Alder reaction with the participation of cyclopentadiene and isopropyl 3-nitroprop-2-enate was examined based on wb97xd/6-311+G(d) (PCM) quantum chemical calculations.
Ewa Dresler, Aneta Wróblewska, Radomir Jasiński   +2 more
doaj   +2 more sources

Analysis of the Reactivity of Z-2-Ar-1-EWG-1-Nitroethene Molecular Segment in the Hetero Diels–Alder Reaction: Experimental and MEDT Quantum Chemical Study [PDF]

Molecules
The relative reactivity of the nitrovinyl molecular segment characterized by the “cis” orientation of nitro group and the aryl ring was evaluated based on the experimental and Density Functional Theory quantum chemical data.
Przemysław Woliński, Agnieszka Kącka-Zych, Ewelina Wielgus, Rafał Dolot, Radomir Jasiński   +4 more
doaj   +2 more sources