Results 21 to 30 of about 4,572 (262)

Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids

Frontiers in Pharmacology, 2021
Endogenous nitro-fatty acids (NFA) are potent electrophilic lipid mediators that exert biological effects in vitro and in vivo via selective covalent modification of thiol-containing target proteins.
Nadine Hellmuth, Camilla Brat, Omar Awad, Omar Awad, Sven George, Astrid Kahnt, Tom Bauer, Hai Phong Huynh Phuoc, Dieter Steinhilber, Carlo Angioni, Mohamed Hassan, Mohamed Hassan, Katharina J. Hock, Georg Manolikakes, Kai Zacharowski, Jessica Roos, Jessica Roos, Thorsten J. Maier, Thorsten J. Maier   +18 more
doaj   +1 more source

On the Mechanism of the Synthesis of Nitrofunctionalised Δ²-Pyrazolines via [3+2] Cycloaddition Reactions between α-EWG-Activated Nitroethenes and Nitrylimine TAC Systems

Organics, 2022
We investigated the reactivity of different substituted nitrylimine-type three atom components (TACs) in [3+2] cycloaddition (32CAs) reactions with electrophilically activated nitroethenes within molecular electron density theory (MEDT).
Agnieszka Fryźlewicz, Aleksandra Olszewska, Karolina Zawadzińska, Przemysław Woliński, Karolina Kula, Agnieszka Kącka-Zych, Agnieszka Łapczuk-Krygier, Radomir Jasiński   +7 more
doaj   +1 more source

One-pot and metal-free synthesis of 3-arylated-4-nitrophenols via polyfunctionalized cyclohexanones from β-nitrostyrenes

Beilstein Journal of Organic Chemistry, 2020
β-Nitrostyrenes underwent a Diels–Alder reaction with Danishefsky’s diene to afford cyclohexenes together with the corresponding hydrolyzed products, 3-arylated-5-methoxy-4-nitrocyclohexanones.
Haruyasu Asahara, Minami Hiraishi, Nagatoshi Nishiwaki   +2 more
doaj   +1 more source

First synthesis of acylated nitrocyclopropanes

Beilstein Journal of Organic Chemistry, 2023
Although nitrocyclopropanedicarboxylic acid esters are widely used in organic syntheses, nitrocyclopropanes with an acyl group have not yet been synthesized.
Kento Iwai, Rikiya Kamidate, Khimiya Wada, Haruyasu Asahara, Nagatoshi Nishiwaki   +4 more
doaj   +1 more source

Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups [PDF]

, 2012
he design and synthesis of a new class of minor groove binder (MGBs) in which, the cationic tail group has been replaced by a neutral, polar variant including cyanoguanidine, nitroalkene, and trifluoroacetamide groups.
Bourdin, Claire, Breen, David, Clements, Carol, Donoghue, Gavin, Fox, Keith, Khalaf, Abedawn, MacMillan, Donna, Scott, Fraser, Sekibo, Doreen, Suckling, Colin   +9 more
core   +1 more source

Nitro-fatty acid formation and metabolism [PDF]

, 2018
Nitro-fatty acids (NO 2 -FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid ...
Bonacci, Gustavo Roberto, Buchan, Gregory J., Fazzari, Marco, Gelhaus Wendell, Stacy, Salvatore, Sonia Rosana   +4 more
core   +1 more source

A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity

Redox Biology, 2021
Chronic metabolic diseases, like obesity, type II diabetes and atherosclerosis often involve a low-grade and sterile systemic inflammatory state, in which activation of the pro-inflammatory transcription factor NF-kB and the NLRP3 inflammasome play a ...
Rosina Dapueto, Jorge Rodriguez-Duarte, Germán Galliussi, Andrés Kamaid, Mariana Bresque, Carlos Batthyány, Gloria V. López, Carlos Escande   +7 more
doaj   +1 more source

Understanding the Regioselectivity and the Molecular Mechanism of [3 + 2] Cycloaddition Reactions between Nitrous Oxide and Conjugated Nitroalkenes: A DFT Computational Study

Molecules, 2022
Regiochemical aspects and the molecular mechanism of the [3 + 2] cycloaddition between nitrous oxide and conjugated nitroalkenes were evaluated on the basis of the wb97xd/6-311 + G(d) (PCM) computational study.
Ewa Dresler, Aneta Wróblewska, Radomir Jasiński   +2 more
doaj   +1 more source

1,4-addition of TMSCCl3to nitroalkenes: efficient reaction conditions and mechanistic understanding [PDF]

, 2014
Improved synthetic conditions allow preparation of TMSCCl3 in good yield (70 %) and excellent purity. Compounds of the type NBu4X [X=Ph3SiF2 (TBAT), F (tetrabutylammonium fluoride, TBAF), OAc, Cl and Br] act as catalytic promoters for 1,4-additions to a ...
Andrew, Arai, Bamford, Benoit Wahl, Berchadsky, Bujok, Clark, Cunico, Dauzonne, Dietmar, Dilman, Dunoguès, Engelhardt, Fujita, Fujita, Gao, Henegar, Hergott, Kharasch, Kharasch, Kister, Korotaev, Korotaev, Korotaev, Lehmann, Li, Lickiss, Lindup, Liu, Maity, Manna, Na Wu, Namboothiri, Okino, Olah, Pilcher, Pons, Prakash, Shibata, Simon Woodward, Speier, Sun, Takayama, Wakabayashi, William Lewis, Xu, Zhang   +46 more
core   +2 more sources

Enantioselective Michael addition of isobutyraldehyde to nitroalkenes organocatalyzed by chiral primary amine-guanidines [PDF]

, 2014
Primary amine-guanidines derived from trans-cyclohexane-1,2-diamines are used as organocatalysts for the enantioselective conjugate addition of isobutyraldehyde to arylated and heteroarylated nitroalkenes.
Chinchilla, Rafael, Fiser, Béla, Gómez Bengoa, Enrique, Nájera, Carmen, Ávila Freire, Ángel   +4 more
core   +2 more sources