The synthesis of chiral β-naphthyl-β-sulfanyl ketones via enantioselective sulfa-Michael reaction in the presence of a bifunctional cinchona/sulfonamide organocatalyst [PDF]
Beilstein Journal of Organic Chemistry, 2021 Cinchona alkaloid-derived organocatalysts are widely employed in various asymmetric transformations, yielding products with high enantiopurity. In this respect, a bifunctional quinine-derived sulfonamide organocatalyst was developed to catalyze the ...
Deniz Tözendemir, Cihangir Tanyeli
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Synthesis of non-racemic 4-nitro-2-sulfonylbutan-1-ones via Ni(II)-catalyzed asymmetric Michael reaction of β-ketosulfones [PDF]
Beilstein Journal of Organic Chemistry, 2019 Functionally substituted sulfones with stereogenic centers are valuable reagents in organic synthesis and key motifs in some bioactive compounds. The asymmetric Michael addition of β-ketosulfones to conjugated nitroalkenes in the presence of Ni(II ...
Alexander N. Reznikov +5 more
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Organocatalytic kinetic resolution of 1,5-dicarbonyl compounds through a retro-Michael reaction [PDF]
Beilstein Journal of Organic ChemistryThe pharmaceutical chemical industry has long used kinetic resolution to obtain high-value compounds. Organocatalysis has recently been added to this strategy, allowing for the resolution of racemic mixtures with low catalyst loadings and mild reaction ...
James Guevara-Pulido +3 more
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Enantioselective Synthesis of Chromanones Bearing an α,α-Disubstituted α-Amino Acid Moiety via Decarboxylative Michael Reaction [PDF]
Molecules, 2019 In this manuscript, a novel, decarboxylative Michael reaction between α-substituted azlactones and chromone-3-carboxylic acids is described. The reaction proceeds in a sequence Michael addition followed by decarboxylative deprotonation, and it ...
Jan Bojanowski +2 more
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Organocatalytic and enantioselective Michael reaction between α-nitroesters and nitroalkenes. Syn/anti-selectivity control using catalysts with the same absolute backbone chirality [PDF]
Beilstein Journal of Organic Chemistry, 2015 The asymmetric and catalytic Michael reaction between α-nitroesters and nitroalkenes has been studied in the presence of two bifunctional catalysts both containing the same absolute chirality at the carbon backbone.
Jose I. Martínez +5 more
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Beilstein Journal of Organic Chemistry, 2021 An organocatalytic asymmetric Michael/acyl transfer reaction between α-nitroketones and 4-arylidenepyrrolidine-2,3-diones is reported. A bifunctional thiourea catalyst was found to be effective for this reaction.
Chandrakanta Parida, Subhas Chandra Pan
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Amino Imidate Catalyzed Asymmetric Michael Reactions of Ketones and Nitroalkenes
SynOpen, 2022 The efficiency of an amino imidate organocatalyst was evaluated in the Michael reaction of ketones with nitroalkenes. tert-Butyl l-proline imidate was found to be a syn-selective catalyst, generating products with moderate to good enantioselectivities ...
Bohdan Sosunovych +2 more
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Structural Analysis of the Michael-Michael Ring Closure (MIMIRC) Reaction Products
Molecules, 2022 A representative number of decalin and hydrindane derivatives 2a–l were prepared in 11–91% yield by means of a cascade reaction of cyclohexanone/cyclopentanone enolates and methyl acrylate through a Michael–Michael ring closure (MIMIRC) process.
Mabel M. Montenegro-Sustaita +4 more
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Thia-Michael Reaction under Heterogeneous Catalysis
Organics, 2023 Thia-Michael reactions between aliphatic and aromatic thiols and various Michael acceptors were performed under environmentally-friendly solvent-free conditions using Amberlyst® A21 as a recyclable heterogeneous catalyst to efficiently obtain the ...
Giovanna Bosica +2 more
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CCXXVI.—The reversibility of the Michael reaction [PDF]
J. Chem. Soc., Trans., 1921 n ...
Ingold, Christopher Kelk +1 more
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